Abstract
3D printing fabrication methods have received lately an enormous attention by the scientific community. Laboratories and research groups working on analytical chemistry applications, among others, have advantageously adopted 3D printing to fabricate a wide range of tools, from common laboratory hardware to fluidic systems, sample treatment platforms, sensing structures, and complete fully functional analytical devices. This technology is becoming more affordable over time and therefore preferred over the commonly used fabrication processes like hot embossing, soft lithography, injection molding and micromilling. However, to better exploit 3D printing fabrication methods, it is important to fully understand their benefits and limitations which are also directly associated to the properties of the materials used for printing. Costs, printing resolution, chemical and biological compatibility of the materials, design complexity, robustness of the printed object, and integration with commercially available systems represent important aspects to be weighted in relation to the intended task. In this review, a useful introductory summary of the most commonly used 3D printing systems and mechanisms is provided before the description of the most recent trends of the use of 3D printing for analytical and bioanalytical chemistry. Concluding remarks will be also given together with a brief discussion of possible future directions.
Graphical abstract
Similar content being viewed by others
References
Huang Y, Leu MC, Mazumder J, Donmez A (2015) Additive manufacturing: current state, future potential, gaps and needs, and recommendations. J Manuf Sci Eng 137:014001–014005
Ngo TD, Kashani A, Imbalzano G, Nguyen KTQ, Hui D (2018) Additive manufacturing (3D printing): a review of materials, methods, applications and challenges. Compos Part B 143:172–196
Berman B (2012) 3-D printing: the new industrial revolution. Bus Horiz 55:155–162
Tofail SAM, Koumoulos EP, Bandyopadhyay A, Bose S, O’Donoghue L, Charitidis C (2018) Additive manufacturing: scientific and technological challenges, market uptake and opportunities. Mater Today 21:22–37
Gross BC, Erkal JL, Lockwood SY, Chen C, Spence DM (2014) Evaluation of 3D printing and its potential impact on biotechnology and the chemical sciences. Anal Chem 86:3240–3253
Gross BC, Lockwood SY, Spence DM (2017) Recent advances in analytical chemistry by 3D printing. Anal Chem 89:57–70
Zhang Y, Ge S, Yu J (2016) Chemical and biochemical analysis on lab-on-a-chip devices fabricated using three-dimensional printing. TrAC Trends Anal Chem 85:166–180
Cocovi-Solberg DJ, Worsfold PJ, Miró M (2018) Opportunities for 3D printed millifluidic platforms incorporating on-line sample handling and separation. TrAC Trends Anal Chem 108:13–22
Ambrosi A, Shi RRS, Webster RD (2020) 3D-printing for electrolytic processes and electrochemical flow systems. J Mater Chem A 8:21902–21929
Erokhin KS, Gordeev EG, Ananikov VP (2019) Revealing interactions of layered polymeric materials at solid-liquid interface for building solvent compatibility charts for 3D printing applications. Sci Rep 9:20177
Gross BC, Anderson KB, Meisel JE, McNitt MI, Spence DM (2015) Polymer coatings in 3D-printed fluidic device channels for improved cellular adherence prior to electrical lysis. Anal Chem 87:6335–6341
Bhattacharjee N, Urrios A, Kang S, Folch A (2016) The upcoming 3D-printing revolution in microfluidics. Lab Chip 16:1720–1742
Waheed S, Cabot JM, Macdonald NP, Lewis T, Guijt RM, Paull B, Breadmore MC (2016) 3D printed microfluidic devices: enablers and barriers. Lab Chip 16:1993–2013
Salentijn GIJ, Oomen PE, Grajewski M, Verpoorte E (2017) Fused deposition modeling 3D printing for (bio)analytical device fabrication: procedures, materials, and applications. Anal Chem 89:7053–7061
Macdonald NP, Cabot JM, Smejkal P, Guijt RM, Paull B, Breadmore MC (2017) Comparing microfluidic performance of three-dimensional (3D) printing platforms. Anal Chem 89:3858–3866
Guo N, Leu MC (2013) Additive manufacturing: technology, applications and research needs. Front Mech Eng 8:215–243
Ambrosi A, Pumera M (2016) 3D-printing technologies for electrochemical applications. Chem Soc Rev 45:2740–2755
Bagheri A, Jin J (2019) Photopolymerization in 3D printing. ACS App Polymer Mat 1:593–611
Mohamed OA, Masood SH, Bhowmik JL (2015) Optimization of fused deposition modeling process parameters: a review of current research and future prospects. Adv Manuf 3:42–53
Lewis JA (2006) Direct ink writing of 3D functional materials. Adv Funct Mater 16:2193–2204
Rocha VG, Saiz E, Tirichenko IS, García-Tuñón E (2020) Direct ink writing advances in multi-material structures for a sustainable future. J Mater Chem A 8:15646–15657
Wang Y, Xu Z, Wu D, Bai J (2020) Current status and prospects of polymer powder 3D printing technologies. Materials 13:2406
Chin SY, Dikshit V, Meera Priyadarshini B, Zhang Y (2020) Powder-based 3D printing for the fabrication of device with micro and mesoscale features. Micromachines 11:658
Au AK, Huynh W, Horowitz LF, Folch A (2016) 3D-printed microfluidics. Angew Chem Int Ed 55:3862–3881
Chan HN, Tan MJA, Wu H (2017) Point-of-care testing: applications of 3D printing. Lab Chip 17:2713–2739
Pearce JM (2014) Chapter 1 - introduction to open-source hardware for science. In: Pearce JM (ed) Open-Source Lab. Elsevier, Boston, pp 1–11
Dhankani KC, Pearce JM (2017) Open source laboratory sample rotator mixer and shaker. HardwareX 1:1–12
Gupta V, Beirne S, Nesterenko PN, Paull B (2018) Investigating the effect of column geometry on separation efficiency using 3D printed liquid chromatographic columns containing polymer monolithic phases. Anal Chem 90:1186–1194
Moleirinho MG, Feast S, Moreira AS, Silva RJS, Alves PM, Carrondo MJT, Huber T, Fee C, Peixoto C (2021) 3D-printed ordered bed structures for chromatographic purification of enveloped and non-enveloped viral particles. Sep Purif Technol 254:117681
Salmean C, Dimartino S (2019) 3D-printed stationary phases with ordered morphology: state of the art and future development in liquid chromatography. Chromatographia 82:443–463
Singh H, Shimojima M, Shiratori T, Van An L, Sugamata M, Yang M (2015) Application of 3D printing technology in increasing the diagnostic performance of enzyme-linked immunosorbent assay (ELISA) for infectious diseases. Sensors 15:16503–16515
Lambert A, Valiulis S, Cheng Q (2018) Advances in optical sensing and bioanalysis enabled by 3D printing. ACS Sens 3:2475–2491
Liu C, Liao S-C, Song J, Mauk MG, Li X, Wu G, Ge D, Greenberg RM, Yang S, Bau HH (2016) A high-efficiency superhydrophobic plasma separator. Lab Chip 16:553–560
Park C, Lee J, Kim Y, Kim J, Lee J, Park S (2017) 3D-printed microfluidic magnetic preconcentrator for the detection of bacterial pathogen using an ATP luminometer and antibody-conjugated magnetic nanoparticles. J Microbiol Methods 132:128–133
Calderilla C, Maya F, Cerdà V, Leal LO (2017) 3D printed device including disk-based solid-phase extraction for the automated speciation of iron using the multisyringe flow injection analysis technique. Talanta 175:463–469
Jue E, Schoepp NG, Witters D, Ismagilov RF (2016) Evaluating 3D printing to solve the sample-to-device interface for LRS and POC diagnostics: example of an interlock meter-mix device for metering and lysing clinical urine samples. Lab Chip 16:1852–1860
Chan K, Coen M, Hardick J, Gaydos CA, Wong K-Y, Smith C, Wilson SA, Vayugundla SP, Wong S (2016) Low-cost 3D printers enable high-quality and automated sample preparation and molecular detection. PLoS One 11:e0158502
Quesada-González D, Merkoçi A (2017) Mobile phone-based biosensing: an emerging “diagnostic and communication” technology. Biosens Bioelectron 92:549–562
Sun Q, Wang J, Tang M, Huang L, Zhang Z, Liu C, Lu X, Hunter KW, Chen G (2017) A new electrochemical system based on a flow-field shaped solid electrode and 3D-printed thin-layer flow cell: detection of Pb2+ ions by continuous flow accumulation square-wave anodic stripping voltammetry. Anal Chem 89:5024–5029
Erkal JL, Selimovic A, Gross BC, Lockwood SY, Walton EL, McNamara S, Martin RS, Spence DM (2014) 3D printed microfluidic devices with integrated versatile and reusable electrodes. Lab Chip 14:2023–2032
Bishop GW, Satterwhite JE, Bhakta S, Kadimisetty K, Gillette KM, Chen E, Rusling JF (2015) 3D-printed fluidic devices for nanoparticle preparation and flow-injection amperometry using integrated Prussian blue nanoparticle-modified electrodes. Anal Chem 87:5437–5443
Shallan AI, Smejkal P, Corban M, Guijt RM, Breadmore MC (2014) Cost-effective three-dimensional printing of visibly transparent microchips within minutes. Anal Chem 86:3124–3130
Tang CK, Vaze A, Rusling JF (2017) Automated 3D-printed unibody immunoarray for chemiluminescence detection of cancer biomarker proteins. Lab Chip 17:484–489
Kadimisetty K, Mosa IM, Malla S, Satterwhite-Warden JE, Kuhns TM, Faria RC, Lee NH, Rusling JF (2016) 3D-printed supercapacitor-powered electrochemiluminescent protein immunoarray. Biosens Bioelectron 77:188–193
Santangelo MF, Libertino S, Turner APF, Filippini D, Mak WC (2018) Integrating printed microfluidics with silicon photomultipliers for miniaturised and highly sensitive ATP bioluminescence detection. Biosens Bioelectron 99:464–470
Sharafeldin M, Kadimisetty K, Bhalerao KS, Chen T, Rusling JF (2020) 3D-printed immunosensor arrays for cancer diagnostics. Sensors 20:4514
Peltomaa R, Amaro-Torres F, Carrasco S, Orellana G, Benito-Peña E, Moreno-Bondi MC (2018) Homogeneous quenching immunoassay for fumonisin B1 based on gold nanoparticles and an epitope-mimicking yellow fluorescent protein. ACS Nano 12:11333–11342
Ang WL, Bonanni A (2019) Unravelling the aptamer-analyte interaction dynamics through fluorescence quenching in graphene quantum dots (GQDs) based homogeneous assays. ChemPlusChem 84:420–426
Rateni G, Dario P, Cavallo F (2017) Smartphone-based food diagnostic technologies: a review. Sensors 17:1453
Hossain A, Canning J, Ast S, Rutledge PJ, Yen TL, Jamalipour A (2015) Lab-in-a-phone: smartphone-based portable Fluorometer for pH measurements of environmental water. IEEE Sensors J 15:5095–5102
Coskun AF, Wong J, Khodadadi D, Nagi R, Tey A, Ozcan A (2013) A personalized food allergen testing platform on a cellphone. Lab Chip 13:636–640
Fang J, Qiu X, Wan Z, Zou Q, Su K, Hu N, Wang P (2016) A sensing smartphone and its portable accessory for on-site rapid biochemical detection of marine toxins. Anal Methods 8:6895–6902
Long KD, Woodburn EV, Le HM, Shah UK, Lumetta SS, Cunningham BT (2017) Multimode smartphone biosensing: the transmission, reflection, and intensity spectral (TRI)-analyzer. Lab Chip 17:3246–3257
Wang Y, Zeinhom MMA, Yang M, Sun R, Wang S, Smith JN, Timchalk C, Li L, Lin Y, du D (2017) A 3D-printed, portable, optical-sensing platform for smartphones capable of detecting the herbicide 2,4-Dichlorophenoxyacetic acid. Anal Chem 89:9339–9346
Sun AC, Yao C, Venkatesh AG, Hall DA (2016) An efficient power harvesting mobile phone-based electrochemical biosensor for point-of-care health monitoring. Sensors Actuators B Chem 235:126–135
Momeni F, Hassani.N SMM, Liu X, Ni J (2017) A review of 4D printing. Mater Design 122:42–79
Shin D-G, Kim T-H, Kim D-E (2017) Review of 4D printing materials and their properties. Int J Precis Eng Manuf-Green Tech 4:349–357
Lui YS, Sow WT, Tan LP, Wu Y, Lai Y, Li H (2019) 4D printing and stimuli-responsive materials in biomedical aspects. Acta Biomater 92:19–36
Khosravani MR, Reinicke T (2020) 3D-printed sensors: current progress and future challenges. Sens Actuat A 305:111916
Trenfield SJ, Awad A, Madla CM, Hatton GB, Firth J, Goyanes A, Gaisford S, Basit AW (2019) Shaping the future: recent advances of 3D printing in drug delivery and healthcare. Expert Opin Drug Deliv 16:1081–1094
Tamay DG, Dursun Usal T, Alagoz AS, Yucel D, Hasirci N, Hasirci V (2019) 3D and 4D printing of polymers for tissue engineering applications. Front Bioeng Biotechnol 7:164
Scida K, Stege PW, Haby G, Messina GA, García CD (2011) Recent applications of carbon-based nanomaterials in analytical chemistry: critical review. Anal Chim Acta 691:6–17
Bonanni A, Pumera M (2013) High-resolution impedance spectroscopy for graphene characterization. Electrochem Commun 26:52–54
Cardoso RM, Kalinke C, Rocha RG, dos Santos PL, Rocha DP, Oliveira PR, Janegitz BC, Bonacin JA, Richter EM, Munoz RAA (2020) Additive-manufactured (3D-printed) electrochemical sensors: a critical review. Anal Chim Acta 1118:73–91
Muñoz J, Pumera M (2020) 3D-printed biosensors for electrochemical and optical applications. TrAC Trends Anal Chem 128:115933
McCreery RL (2008) Advanced carbon electrode materials for molecular electrochemistry. Chem Rev 108:2646–2687
Chen D, Tang LH, Li JH (2010) Graphene-based materials in electrochemistry. Chem Soc Rev 39:3157–3180
Li K, Wei H, Liu W, Meng H, Zhang P, Yan C (2018) 3D printed stretchable capacitive sensors for highly sensitive tactile and electrochemical sensing. Nanotechnology 29:185501
Lind JU, Busbee TA, Valentine AD, Pasqualini FS, Yuan H, Yadid M et al (2016) Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing. Nat Mater 16:303
Manzanares Palenzuela CL, Novotný F, Krupička P, Sofer Z, Pumera M (2018) 3D-printed graphene/polylactic acid electrodes promise high sensitivity in electroanalysis. Anal Chem 90:5753–5757
Rymansaib Z, Iravani P, Emslie E, Medvidović-Kosanović M, Sak-Bosnar M, Verdejo R, Marken F (2016) All-polystyrene 3D-printed electrochemical device with embedded carbon nanofiber-graphite-polystyrene composite conductor. Electroanalysis 28:1517–1523
Manzanares-Palenzuela CL, Hermanova S, Sofer Z, Pumera M (2019) Proteinase-sculptured 3D-printed graphene/polylactic acid electrodes as potential biosensing platforms: towards enzymatic modeling of 3D-printed structures. Nanoscale 11:12124–12131
Richter EM, Rocha DP, Cardoso RM, Keefe EM, Foster CW, Munoz RAA, Banks CE (2019) Complete additively manufactured (3D-printed) electrochemical sensing platform. Anal Chem 91:12844–12851
Ambrosi A, Moo JGS, Pumera M (2016) Helical 3D-printed metal electrodes as custom-shaped 3D platform for electrochemical devices. Adv Funct Mater 26:698–703
Lee KY, Ambrosi A, Pumera M (2017) 3D-printed metal electrodes for heavy metals detection by anodic stripping voltammetry. Electroanalysis 29:2444–2453
Loo AH, Chua CK, Pumera M (2017) DNA biosensing with 3D printing technology. Analyst 142:279–283
Tan G, Nasir MZM, Ambrosi A, Pumera M (2017) 3D printed electrodes for detection of nitroaromatic explosives and nerve agents. Anal Chem 89:8995–9001
Liyarita BR, Ambrosi A, Pumera M (2018) 3D-printed electrodes for sensing of biologically active molecules. Electroanalysis 30:1319–1326
Ambrosi A, Pumera M (2018) Multimaterial 3D-printed water electrolyzer with earth-abundant electrodeposited catalysts. ACS Sustain Chem Eng 6:16968–16975
Acknowledgements
A.A. and A.B. acknowledge the support of the Double-Hundred Program for Foreign Experts of Shandong Province (WST2019011). A.B. gratefully acknowledges Ministry of Education (MOE), AcRF Tier 1 grant (Reference No: RG9/19) for the financial support.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare no competing interests.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This article is part of the Topical Collection on 3D printing Manufacturing Technologies for the Advancement of Analytical Sciences
Rights and permissions
About this article
Cite this article
Ambrosi, A., Bonanni, A. How 3D printing can boost advances in analytical and bioanalytical chemistry. Microchim Acta 188, 265 (2021). https://doi.org/10.1007/s00604-021-04901-2
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s00604-021-04901-2