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Ultra-sensitive amperometric determination of quercetin by using a glassy carbon electrode modified with a nanocomposite prepared from aminated graphene quantum dots, thiolated β-cyclodextrin and gold nanoparticles

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Abstract

Thiolated β-cyclodextrin functionalized gold nanoparticles (Au-β-CDs) with layered wrinkled flower structure were prepared. Au-β-CDs were electrostatically combined with protonated aminated graphene quantum dots (NH2-GQDs) to form a nanocomposite with better supramolecular recognition, conductivity, catalysis and dispersion properties. For constructing a quercetin (QU) sensor, the nanocomposites were one-step electrodeposited by a cyclic voltammetry (CV) method onto a glassy carbon electrode to form a stable film. Under optimized conditions, the sensor showed a wide linear response range of 1–210 nM, with a lower detection limit of 285 pM. At the same time, flavonoids with similar structures hardly interfere with the determination of QU. The sensor has been used to determine QU in honey, tea, honeysuckle and human serum with satisfactory results.

Schematic representation of the fabrication of an ultrasensitive quercetin electrochemical sensor based on aminated graphene quantum dots, thiolated β-cyclodextrin and gold nanoparticles (NH2-GQDs/Au-β-CD/GCE).

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Acknowledgments

This research is supported by the National Natural Science Foundation of China (31701613, 21874114, 21475114).

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Author notes

  1. Zhidu Zhou and Pengcheng Zhao contributed equally to this work.

Authors and Affiliations

  1. Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, 411105, People’s Republic of China

    Zhidu Zhou, Pengcheng Zhao, Chenxi Wang, Pingping Yang, Yixi Xie & Junjie Fei

  2. Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Xiangtan University, Xiangtan, 411105, People’s Republic of China

    Yixi Xie

  3. Hunan Institute of Advanced Sensing and Information Technology, Xiangtan University, Xiangtan, 411105, People’s Republic of China

    Junjie Fei

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  1. Zhidu Zhou
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Zhou, Z., Zhao, P., Wang, C. et al. Ultra-sensitive amperometric determination of quercetin by using a glassy carbon electrode modified with a nanocomposite prepared from aminated graphene quantum dots, thiolated β-cyclodextrin and gold nanoparticles. Microchim Acta 187, 130 (2020). https://doi.org/10.1007/s00604-019-4106-1

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