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Photoluminescent coral-like carbon-branched polymers as nanoprobe for fluorometric determination of captopril

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Abstract

The authors describe the synthesis of fluorescent coral-like carbon nano-branched polymers (PCNBPs) co-doped with nitrogen and phosphorus. Uric acid and phosphoric acid act as nitrogen and phosphorus sources, respectively. The PCNBPs have a coral-like branched structure, are cross-connected, and < 20 nm in skeleton diameter. Their blue fluorescence, best measured at excitation/emission wavelengths of 330/425 nm, is quenched by mercury (II) ions due to the specifically restricted rigid conformation caused by the interaction of phosphorus, nitrogen, and oxygen groups on the surface of the PCNBPs. Fluorescence is selectivity quenched by Hg(II) but restored in addition of the hypertension drug captopril (CAP) in the range 50 nM to 40 μM concentration range. Fluorescence recovery is attributed to the effectively specific interactions between the thiol group of CAP and Hg(II). The method was applied to the determination of the concentration of Cap in pharmaceutical samples, and recoveries were between 97.6 and 105.1%.

Fluorescent coral-like carbon nano-branched polymers (PCNBPs) co-doped with nitrogen and phosphorus are described. Their fluorescence is selectivity quenched by Hg(II) but restored in addition of the hypertension drug captopril (Cap) in the range 50 nM to 40 μM concentration range.

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Acknowledgements

We greatly appreciate the support of the National Natural Science Foundation of China (21705140, 21575123, 21675139, 21603184) and the Natural Science Foundation of Jiangsu Province (BK20170474), and sponsored by Qing Lan Project and the Innovative Research Project of Key Laboratory of Functional Inorganic Material Chemistry, Ministry of Education. The opening project of Jiangsu Key Laboratory of Biochemistry and Biotechnology of Marine Wetland (K2016-17, K2016-20).

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  1. School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng, 224051, China

    Zhong-Xia Wang, Yuan-Fei Gao, Xian-He Yu, Fen-Ying Kong, Wei-Xin Lv & Wei Wang

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  1. Zhong-Xia Wang
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  2. Yuan-Fei Gao
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Correspondence to Wei Wang.

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Wang, ZX., Gao, YF., Yu, XH. et al. Photoluminescent coral-like carbon-branched polymers as nanoprobe for fluorometric determination of captopril. Microchim Acta 185, 422 (2018). https://doi.org/10.1007/s00604-018-2961-9

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