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Halloysite nanotubes in analytical sciences and in drug delivery: A review

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Abstract

Halloysite (HNT) is a natural inorganic mineral that has many applications in manufacturing. This review (with 192 references) covers (a) the chemical properties of halloysites, (b) the effects of alkali and acid etching on the loading capacity and the release behavior of halloysites, (c) the use of halloysite nanotubes in analytical sciences and drug delivery, and (d) recent trends in the preparation of magnetic HNTs. Synthetic methods such as co-precipitation, thermal decomposition, and solvothermal method are discussed, with emphasis on optimal magnetization. In the analytical field, recent advancements are summarized in terms of applications of HNT-nanocomposites for extraction and detection of heavy metal ions, dyes, organic pollutants, and biomolecules. The review also covers methods for synthesizing molecularly imprinted polymer-modified HNTs and magnetic HNTs. With respect to drug delivery, the toxicity, techniques for drug loading and the various classes of drug-halloysite nanocomposites are discussed. This review gives a general insight on the utilization of HNT in analytical determination and drug delivery systems which may be useful for researchers to generate new ideas.

Schematic presentation of the structure of halloysite nanotubes, selected examples of modifications and functionalization, and represetative field of applications.

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Acknowledgements

This work was financially supported by the China Scholarship Consul (CSC) grant (No. 2013012007), Independent innovation fund project of agricultural science and technology of Jiangsu Province in 2017(No CX(17)1003), Guizhou Provincial Science and Technology Department Joint Fund Project (Qian Kehe LH word [2016] No. 7076), the Project Funded by Research Project of Environment Protection Department of Jiangsu Province (Grant No.2015026) and Chinese College Students Innovation Project for the R&D of Novel Drugs.

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  1. Department of Analytical Chemistry, School of Sciences, China Pharmaceutical University, Nanjing, 210009, Jiangsu, China

    Meriem Fizir, Pierre Dramou, Nasiru Sintali Dahiru, Wang Ruya, Tao Huang & Hua He

  2. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 211198, China

    Hua He

  3. Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu Province, 211198, China

    Hua He

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  1. Meriem Fizir
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Correspondence to Meriem Fizir or Hua He.

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Fizir, M., Dramou, P., Dahiru, N.S. et al. Halloysite nanotubes in analytical sciences and in drug delivery: A review. Microchim Acta 185, 389 (2018). https://doi.org/10.1007/s00604-018-2908-1

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