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Application of spinel-structured MgFe2O4 nanoparticles for simultaneous electrochemical determination diclofenac and morphine

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Abstract

The paper describes a sensitive method for simultaneous sensing of morphine (MOR) and diclofenac (DCF). The surface of a MgFe2O4/graphite paste electrode was modified with multi-walled carbon nanotubes, and the resulting sensor was characterized by cyclic voltammetry, differential pulse voltammetry, chronoamperometry, and electrochemical impedance spectroscopy. The electrode showed an efficient synergistic effect in term of oxidation of DCF and MOR, with sharp oxidation peaks occurring at +0.370 and 0.540 V (vs Ag/AgCl) at pH 7.0. The calibration plot for MOR is linear in the 50 nM to 920 μM concentration range, and the detection limit is 10 nM (at a signal-to-noise ratio of 3). The respective data for DCF are 100 nM to 580 μM, with a 60 nM LOD. The sensor was applied to the determination of MOR and DCF in spiked serum and urine samples, with recoveries ranging between 91.4 and 100.7 %.

A sensitive method for simultaneous sensing of morphine (MOR) and diclofenac (DCF) is described. The surface of MgFe2O4/graphite paste electrode was modified with multi-walled carbon nanotubes, and the resulting sensor showed an efficient synergistic effect in terms of oxidation of DCF and MOR. The calibration plot for MOR is linear in the 50 nM to 920 μM concentration range, and the detection limit is 10 nM. The respective data for DCF are 100 nM to 580 μM, with a 60 nM LOD.

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Authors and Affiliations

  1. Chemistry Department, Payame Noor University, Tehran, 19395-3697, Iran

    Fatemeh Basiri & Masoumeh Taei

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  1. Fatemeh Basiri
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  2. Masoumeh Taei
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Correspondence to Masoumeh Taei.

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Basiri, F., Taei, M. Application of spinel-structured MgFe2O4 nanoparticles for simultaneous electrochemical determination diclofenac and morphine. Microchim Acta 184, 155–162 (2017). https://doi.org/10.1007/s00604-016-1995-0

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  • DOI: https://doi.org/10.1007/s00604-016-1995-0

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