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A reversible fluorescent INHIBIT logic gate for determination of silver and iodide based on the use of graphene oxide and a silver–selective probe DNA

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Abstract

We describe a reversible fluorescent DNA–based INHIBIT logic gate for the determination of silver(I) and iodide ions using graphene oxide (GO) as a signal transducer and Ag(I) and iodide as mechanical activators. The basic performance, optimized conditions, sensitivity and selectivity of the logic gate were investigated and revealed that the method is highly sensitive and selective over potentially interfering ions. The limits of detection for Ag(I) and iodide are 10 nM and 50 nM, respectively. This logic gate was successfully applied to the determination of Ag(I) and iodide in (spiked) tap water and river water. It was also used for the determination of iodide in human urine samples with satisfactory results. Compared to other methods, this INHIBIT logic gate is simple in design and has small background interference.

A simple and reversible fluorescent DNA-based INHIBIT logic gate is designed by using graphene oxide as a signal transducer and silver ions and iodide as mechanical activators.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (21173071) and the key projects of science and technology of Henan Educational Committee (Grant No. 14B150049).

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We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007, People’s Republic of China

    Hua Lv, Shuang Li, Yumin Liu, Gongke Wang, Xiang Li, Yan Lu & Jianji Wang

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  1. Hua Lv
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  2. Shuang Li
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  3. Yumin Liu
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  4. Gongke Wang
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Correspondence to Yumin Liu or Jianji Wang.

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Lv, H., Li, S., Liu, Y. et al. A reversible fluorescent INHIBIT logic gate for determination of silver and iodide based on the use of graphene oxide and a silver–selective probe DNA. Microchim Acta 182, 2513–2520 (2015). https://doi.org/10.1007/s00604-015-1620-7

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