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Fast and sensitive determination of doxorubicin using multi-walled carbon nanotubes as a sensor and CoFe2O4 magnetic nanoparticles as a mediator

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Abstract

Spinel-structured cobalt ferrite (CoFe2O4) magnetic nanoparticles (MNPs) were synthesized by a modified chemical coprecipitation method. The MNPs were characterized by X-ray diffraction, field emission scanning electron microscopy and Fourier transform infrared spectroscopy. Then, a doxorubicin sensor was constructed by modifying a carbon paste electrode with multi-walled carbon nanotubes (MWCNTs) and the MNPs. Under optimized conditions, the differential pulse voltammetric response of the modified electrode at a working voltage of 0.46 V vs. Ag/AgCl is related to the concentration of doxorubicin in the 0.05–1150 nM range, with a 10 pM detection limit at a signal-to-noise ratio of 3.

Fabrication process of MWCNT/CoFe2O4 modified carbon paste electrode for electrocatalytic determination of doxorubicin. a) CPE and b) MWCNT/CoFe2O4/CPE.

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Authors and Affiliations

  1. Department of Chemistry, Payame Noor University, 19395-4697, Tehran, Islamic Republic of Iran

    Masoumeh Taei, Foroozan Hasanpour, Hossein Salavati & Shekofeh Mohammadian

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  1. Masoumeh Taei
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  2. Foroozan Hasanpour
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  3. Hossein Salavati
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  4. Shekofeh Mohammadian
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Correspondence to Masoumeh Taei.

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Taei, M., Hasanpour, F., Salavati, H. et al. Fast and sensitive determination of doxorubicin using multi-walled carbon nanotubes as a sensor and CoFe2O4 magnetic nanoparticles as a mediator. Microchim Acta 183, 49–56 (2016). https://doi.org/10.1007/s00604-015-1588-3

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  • DOI: https://doi.org/10.1007/s00604-015-1588-3

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