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Impact of gastrectomy on body composition within 1 month in patients with gastric cancer

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Abstract

Purpose

The present study examined the changes in and risk factors for body composition (BC) during the first postoperative month when dynamic biological reactions occur.

Methods

We retrospectively assessed 202 patients who underwent gastrectomy. The BC was assessed using a bioelectrical impedance analysis and evaluated within 1 month preoperatively, 1 week postoperatively, and 1 month postoperatively. Multiple regression analyses were performed to identify predictive factors for BC change.

Results

The mean reduction rate in BC at 1 month postoperatively was − 6.0, − 10.5, − 5.6, − 1.1, − 10.1, and + 1.2% for body weight, body fat, skeletal muscle, bone mineral, extracellular water/total body water, and the whole-body phase angle, respectively. A multiple regression analysis revealed that independent risk factors for weight loss were complications, operative time, and type of gastrectomy (P = 0.004, 0.011, 0.015, respectively), and those for skeletal muscle loss were complications and gastrectomy type (P = 0.002, 0.010, respectively). A segmental lean mass analysis revealed that the lower limbs were markedly reduced at 1 week postoperatively (− 8.0%), and these independent risk factors were the female sex and Stage II/III disease (P = 0.008, 0.036, respectively).

Conclusion

Detailed analyses of BC might help elucidate the mechanisms underlying postoperative physical changes, which might be useful for perioperative management.

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Data availability

The data that support the findings of this study are available on request from the corresponding author, [T.O]. The data are not publicly available due to [restrictions e.g. their containing information that could compromise the privacy of research participants].

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Acknowledgements

We thank Editage Group (https://www.editage.jp/services/english-editing) for the English language editing of the manuscript.

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Authors and Affiliations

  1. Department of Surgery, Tottori Prefectural Central Hospital, 730 Ezu, Tottori, 680-0901, Japan

    Tomohiro Osaki, Ei Uchinaka, Yoichiro Tada, Keigo Ashida & Shigeru Tatebe

  2. Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, 36-1 Nishi-Cho, Yonago, 683-8504, Japan

    Tomoyuki Matsunaga, Masahiro Makinoya, Yuji Shishido, Kozo Miyatani & Yoshiyuki Fujiwara

Authors
  1. Tomohiro Osaki
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  2. Tomoyuki Matsunaga
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Correspondence to Tomohiro Osaki.

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Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

Written informed consent was not obtained from the patients, but all patients were previously informed in the form of an opt-out option.

Ethics approval

This study was approved by the ethics boards of the Tottori Prefectural Central Hospital (approval number: 2020–23) and Tottori University Hospital (approval number: 22A036).

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Osaki, T., Matsunaga, T., Makinoya, M. et al. Impact of gastrectomy on body composition within 1 month in patients with gastric cancer. Surg Today 53, 834–844 (2023). https://doi.org/10.1007/s00595-022-02633-1

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  • DOI: https://doi.org/10.1007/s00595-022-02633-1

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