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Risk factors for surgical site infection in Japanese patients with ulcerative colitis: a multicenter prospective study

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Abstract

Purpose

A prospective, multicenter, observational study was performed to investigate the risk factors of surgical site infection (SSI) in patients with ulcerative colitis (UC).

Methods

From 2009 to 2010, perioperative clinicopathological data were collected from patients who had undergone surgery for UC within the research period, for up to 6 consecutive months in 13 hospitals in Japan. The primary outcome was the development of SSI.

Results

A total of 195 patients with UC who underwent colorectal surgery were enrolled. SSI was diagnosed in 38 (19.5 %) patients, in the form of incisional infection in 23 (11.8 %), organ/space infection in 16 (8.2 %), and both in 1 (0.5 %). There were no significant risk factors associated with an increased risk of development of incisional SSI. An American Society of Anesthesiologists physical status of ≥ 3 was indicated as the only significant risk factor for organ/space SSI (P = 0.02) compared with other factors, such as a neutrophil count of >100 × 102/mm3, albumin level of <3.5 g/dl, perioperative packed red blood cell transfusion, fair or poor colonic cleanliness, and therapeutic use of antibiotics.

Conclusion

Poor general physical status was the significant independent risk factor for organ/space SSI in patients with UC in Japan.

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Acknowledgments

This study was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan and by Labor Sciences Research Grants for Intractable Diseases from the Ministry of Health, Labor, and Welfare of Japan.

Conflict of interest

We have no conflicts of interest to declare.

Author information

Authors and Affiliations

  1. Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan

    Toshimitsu Araki, Yoshiki Okita, Yasuhiko Mohri & Masato Kusunoki

  2. Department of Lower Gastroenterological Surgery, Hyogo College of Medicine, Nishinomiya, Japan

    Motoi Uchino & Masato Kusunoki

  3. Inflammatory Bowel Disease Center, Hyogo College of Medicine, Nishinomiya, Japan

    Hiroki Ikeuchi

  4. Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan

    Iwao Sasaki

  5. Department of Colorectal Surgery, Tohoku Rosai Hospital, Sendai, Japan

    Yuji Funayama

  6. Division of Molecular and Surgical Pathophysiology, Graduate School of Medicine, Tohoku University, Sendai, Japan

    Kouhei Fukushima

  7. Department of Surgery, Chikushi Hospital, Fukuoka University, Chikushino, Japan

    Kitarou Futami

  8. Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan

    Kiyoshi Maeda

  9. Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

    Tsuneo Iiai

  10. Department of Surgery II, Tokyo Women’s Medical University, Tokyo, Japan

    Michio Itabashi

  11. Department of Surgery, National Defense Medical College, Tokorozawa, Japan

    Kazuo Hase

  12. IBD Center, Sapporo Kosei General Hospital, Sapporo, Japan

    Satoshi Motoya

  13. Department of Gastroenterology, Wakakusa First Hospital, Osaka, Japan

    Atsuo Kitano

  14. Department of Surgery, Osaka University Graduate School of Medicine, Suita, Japan

    Tsunekazu Mizushima

  15. Department of Surgery, Fujita Health University, School of Medicine, Toyoake, Japan

    Kotaro Maeda

  16. Department of Innovative Surgery and Surgical Techniques Development, Mie University Graduate School of Medicine, Tsu, Japan

    Minako Kobayashi

Authors
  1. Toshimitsu Araki
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  2. Yoshiki Okita
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  3. Motoi Uchino
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  4. Hiroki Ikeuchi
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  5. Iwao Sasaki
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  6. Yuji Funayama
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  7. Kouhei Fukushima
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  8. Kitarou Futami
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  9. Kiyoshi Maeda
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  10. Tsuneo Iiai
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  11. Michio Itabashi
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  12. Kazuo Hase
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  13. Satoshi Motoya
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  14. Atsuo Kitano
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  15. Tsunekazu Mizushima
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  16. Kotaro Maeda
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  17. Minako Kobayashi
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  18. Yasuhiko Mohri
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  19. Masato Kusunoki
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Corresponding author

Correspondence to Toshimitsu Araki.

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Araki, T., Okita, Y., Uchino, M. et al. Risk factors for surgical site infection in Japanese patients with ulcerative colitis: a multicenter prospective study. Surg Today 44, 1072–1078 (2014). https://doi.org/10.1007/s00595-013-0809-9

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  • DOI: https://doi.org/10.1007/s00595-013-0809-9

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