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Primary adenosquamous carcinoma of the colon: Report of five cases

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Abstract

Primary adenosquamous cell carcinomas (Ad-SCCs) of the colon and rectum are rare malignancies with a poor prognosis, in comparison to adenocarcinoma alone. Different roles of human papilloma virus (HPV) in its pathogenesis have been reported and the role of P16 in Ad-SCCs has not been explored. This report presents five cases of Ad-SCC of the colon to explore the clinicopathological features and the roles of P16, HPV 6/11, and 16/18. There was no confirmed evidence to support the relationship between the infection of HPV 6/11, 16/18, and pathogenesis of Ad-SCC of the colon. P16 overexpression was not related to HPV carcinogenesis and there might be another mechanism of P16 upregulation in Ad-SCC of the colon.

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References

  1. Nakada I, Tabuchi T, Nakachi T, Shimazaki J, Konishi S, Katano M, et al. Histological factors contributing to a high risk of recurrence of submucosal invasive cancer (pT1) of the colon and rectum after endoscopic therapy. Surg Today 2008;38:675–678.

    Article  PubMed  Google Scholar 

  2. Cagir B, Nagy MW, Topham A, Rakinic J, Fry RD. Adenosquamous carcinoma of the colon, rectum, and anus: epidemiology, distribution, and survival characteristics. Dis Colon Rectum 1999;42:258–263.

    Article  PubMed  CAS  Google Scholar 

  3. Frizelle FA, Hobday KS, Batts KP, Nelson H. Adenosquamous and squamous carcinoma of the colon and upper rectum: a clinical and histopathologic study. Dis Colon Rectum 2001;44:341–346.

    Article  PubMed  CAS  Google Scholar 

  4. Audeau A, Han HW, Johnston MJ, Whitehead MW, Frizelle FA. Does human papilloma virus have a role in squamous cell carcinoma of the colon and upper rectum? Eur J Surg Oncol 2002;28:657–660.

    Article  PubMed  CAS  Google Scholar 

  5. Kong CS, Welton ML, Longacre TA. Role of human papillomavirus in squamous cell metaplasia-dysplasia-carcinoma of the rectum. Am J Surg Pathol 2007;31:919–925.

    Article  PubMed  Google Scholar 

  6. Sotlar K, Koveker G, Aepinus C, Selinka HC, Kandolf R, Bultmann B. Human papillomavirus type 16-associated primary squamous cell carcinoma of the rectum. Gastroenterology 2001;120:988–994.

    Article  PubMed  CAS  Google Scholar 

  7. Agoff SN, Lin P, Morihara J, Mao C, Kiviat NB, Koutsky LA. p16(INK4a) expression correlates with degree of cervical neoplasia: a comparison with Ki-67 expression and detection of high-risk HPV types. Mod Pathol 2003;16:665–673.

    Article  PubMed  Google Scholar 

  8. Klussmann JP, Gultekin E, Weissenborn SJ, Wieland U, Dries V, Dienes HP, et al. Expression of p16 protein identifies a distinct entity of tonsillar carcinomas associated with human papillomavirus. Am J Pathol 2003;162:747–753.

    PubMed  CAS  Google Scholar 

  9. Lu DW, El-Mofty SK, Wang HL. Expression of p16, Rb, and p53 proteins in squamous cell carcinomas of the anorectal region harboring human papillomavirus DNA. Mod Pathol 2003;16:692–699.

    Article  PubMed  Google Scholar 

  10. Anagnostopoulos G, Sakorafas GH, Kostopoulos P, Grigoriadis K, Pavlakis G, Margantinis G, et al. Squamous cell carcinoma of the rectum: a case report and review of the literature. Eur J Cancer Care (Engl) 2005;14:70–74.

    Article  CAS  Google Scholar 

  11. Gelas T, Peyrat P, Francois Y, Gerard JP, Baulieux J, Gilly FN, et al. Primary squamous-cell carcinoma of the rectum: report of six cases and review of the literature. Dis Colon Rectum 2002;45:1535–1540.

    Article  PubMed  Google Scholar 

  12. Kang H, O’Connell JB, Leonardi MJ, Maggard MA, McGory ML, Ko CY. Rare tumors of the colon and rectum: a national review. Int J Colorectal Dis 2007;22:183–189.

    Article  PubMed  Google Scholar 

  13. Ouban A, Nawab RA, Coppola D. Diagnostic and pathogenetic implications of colorectal carcinomas with multidirectional differentiation: a report of 4 cases. Clin Colorectal Cancer 2002;1:243–248.

    Article  PubMed  Google Scholar 

  14. Jaworski RC, Biankin SA, Baird PJ. Squamous cell carcinoma in situ arising in inflammatory cloacogenic polyps: report of two cases with PCR analysis for HPV DNA. Pathology 2001;33:312–314.

    Article  PubMed  CAS  Google Scholar 

  15. Yurdakul G, de Reijke TM, Blank LE, Rauws EA. Rectal squamous cell carcinoma 11 years after brachytherapy for carcinoma of the prostate. J Urol 2003;169:280.

    Article  PubMed  Google Scholar 

  16. Balfour TW. Does squamous carcinoma of the colon exist? Br J Surg 1972;59:410–412.

    Article  PubMed  CAS  Google Scholar 

  17. Bosch FX, Lorincz A, Munoz N, Meijer CJ, Shah KV. The causal relation between human papillomavirus and cervical cancer. J Clin Pathol 2002;55:244–265.

    PubMed  CAS  Google Scholar 

  18. Pu RT, Pang Y, Michael CW. Utility of WT-1, p63, MOC31, mesothelin, and cytokeratin (K903 and CK5/6) immunostains in differentiating adenocarcinoma, squamous cell carcinoma, and malignant mesothelioma in effusions. Diagn Cytopathol 2008;36:20–25.

    Article  PubMed  Google Scholar 

  19. Papotti M, Sapino A, Righi L, Chiappone S, Bussolati G. 34betaE12 cytokeratin immunodetection in the differential diagnosis of neuroendocrine carcinomas of the breast. Appl Immunohistochem Mol Morphol 2001;9:229–233.

    Article  PubMed  CAS  Google Scholar 

  20. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin 2007;57:43–66.

    Article  PubMed  Google Scholar 

  21. Petrelli NJ, Valle AA, Weber TK, Rodriguez-Bigas M. Adenosquamous carcinoma of the colon and rectum. Dis Colon Rectum 1996;39:1265–1268.

    Article  PubMed  CAS  Google Scholar 

  22. Pikarsky AJ, Belin B, Efron J, Woodhouse S, Weiss EG, Wexner SD, et al. Squamous cell carcinoma of the rectum in ulcerative colitis: case report and review of the literature. Int J Colorectal Dis 2007;22:445–447.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Anesthesiology, Medical School of Nanjing University, Nanjing Stomatology Hospital, Nanjing, PR China

    Yingchun Dong

  2. Department of Pathology, Nanjing Jinling Hospital, 305 Zhongshan Dong Lu, Nanjing, 210002, PR China

    Jiandong Wang, Henghui Ma, Hangbo Zhou, Guangming Lu & Xiaojun Zhou

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  1. Yingchun Dong
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  2. Jiandong Wang
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  3. Henghui Ma
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  5. Guangming Lu
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  6. Xiaojun Zhou
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Dong, Y., Wang, J., Ma, H. et al. Primary adenosquamous carcinoma of the colon: Report of five cases. Surg Today 39, 619–623 (2009). https://doi.org/10.1007/s00595-008-3884-6

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  • DOI: https://doi.org/10.1007/s00595-008-3884-6

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