Abstract
PURPOSE: Adenosquamous carcinomas of the colon and rectum are rare tumors. These tumors have malignant glandular and squamous components capable of metastasizing. We report seven patients with adenosquamous carcinoma of the colon and rectum and their clinical outcomes. METHODS: Retrospective review was undertaken of seven patients who were identified by the tumor registry at Roswell Park Cancer Institute between 1971 and 1994. RESULTS: These represent a 0.18 percent incidence of adenocarcinomas in our institution. There were five tumors located in the rectum and two in the colon. All patients were Stage III or IV on presentation. Median overall survival was 23 months. In three patients, the tumor was associated with ulcerative colitis; in one of these patients, hypercalcemia was present. All patients died of their disease or with the disease. CONCLUSIONS: Previously reported aggressive behavior of this cancer is confirmed in our series.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Comer PT, Beahrs OH, Dockerty MB. Primary squamous cell carcinoma and adenoacanthoma of the colon. Cancer 1971;28:1111–7.
Erasmus L, Van Herdeen A, Dahlin DC. Adenoacanthoma of the colon. Dis Colon Rectum 1978;21:196–8.
Crissman JD. Adenosquamous and squamous cell carcinoma of the colon. Am J Surg Pathol 1978;2:47–54.
Michelassi F, Montag AG, Block GE. Adenosquamous-cell carcinoma in ulcerative colitis: report of a case. Dis Colon Rectum 1988;31:323–6.
Boscaino A, Orabona P, Donofrio V, Mossetti G, Darmiento FP. Adenosquamous carcinoma of the colon: case report of an unusual type. Tumori 1993;78:288–90.
Beahrs OH, Henson DE, Hutter RV, Kennedy BJ, eds. Manual for staging of cancer, American Joint Committee on Cancer. 4th ed. Philadelphia: JB Lippincott, 1992:75–9.
Herxheimer G. Ober heterologe Cancroide. Beitr Pathol Anat 1907;41:348–412.
Kontozoglou TE, Moyana TN. Adenosquamous carcinoma of the colon—an immunocytochemical and ultrastructural study: report of two cases and review of the literature. Dis Colon Rectum 1989;32:716–21.
Cerezo L, Alvarez M, Edwards O, Price G. Adenosquamous carcinoma of the colon. Dis Colon Rectum 1985; 28:597–603.
Steele VE, Netteshelm P. Unstable cellular differentiation in adenosquamous cell carcinoma. J Natl Cancer Inst 1981;67:149–54.
Chevinsky AH, Berelowitz M, Hoover HC Jr. Adenosquamous carcinoma of the colon presenting with hypercalcemia. Cancer 1987;60:1111–6.
Links M, Ho H, Clingan P, Diamond T. Hypercalcemia in a patient with fatal adenosquamous carcinoma of the colon. Med J Aust 1994;160:286–7.
Berkelhammer CH, Baker AL, Block GE, Bostwick DG, Michelassi F. Humoral hypercalcemia complicating adenosquamous carcinoma of the proximal colon. Dig Dis Sci 1989;34:142–7.
Author information
Authors and Affiliations
About this article
Cite this article
Petrelli, N.J., Valle, A.A., Weber, T.K. et al. Adenosquamous carcinoma of the colon and rectum. Dis Colon Rectum 39, 1265–1268 (1996). https://doi.org/10.1007/BF02055120
Issue Date:
DOI: https://doi.org/10.1007/BF02055120