Abstract
Purpose
To assess the degree of penetration of intravenous (i.v.) ciprofloxacin into the lung parenchyma resected for lung carcinoma in Japanese patients.
Methods
Ciprofloxacin was given i.v. over 1 h to ten Japanese patients with non-small cell lung carcinoma. We took 1 g of normal lung parenchyma and 1 ml of blood serum for analysis when the lung was resected. Ciprofloxacin concentrations were determined by high-performance liquid chromatography.
Results
The mean time from the end of ciprofloxacin administration to lung resection was 135 ± 55 min (range, 75–223 min). The mean concentrations of ciprofloxacin in the lung parenchyma and blood serum were 4.9 ± 2.0 µg/g (range, 2.1–7.9) and 1.5 ± 0.7 µg/ml (range, 0.8–2.7). The mean tissue per serum concentration ratio was 3.6 ± 2.2 (range, 1.9–8.7).
Conclusion
The concentrations of ciprofloxacin in the lung parenchyma after i.v. administration in Japanese patients were above the minimal inhibitory concentration for bacteria from at least 75 min until 4 h later.
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Haraguchi, S., Hioki, M., Yamashita, K. et al. Ciprofloxacin Penetration into the Pulmonary Parenchyma in Japanese Patients. Surg Today 37, 282–284 (2007). https://doi.org/10.1007/s00595-006-3393-4
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DOI: https://doi.org/10.1007/s00595-006-3393-4