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Circulating IL-8 levels are increased in patients with type 2 diabetes and associated with worse inflammatory and cardiometabolic profile

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Abstract

Aims

Interleukin-8 (IL-8) is a chemokine involved in systemic immunity, macrophages infiltration and activation in adipose tissue and may play a significant role in the pathogenesis of type 2 diabetes (T2D) and atherosclerosis. Aims of this study were to evaluate circulating IL-8 levels in adult patients with T2D in comparison with non-diabetic subjects and to describe clinical and biochemical correlates of IL-8 concentration.

Methods

For this cross-sectional study, we enrolled 79 consecutive T2D individuals referring to our diabetes outpatient clinics at Sapienza University of Rome, and 37 sex, age and BMI comparable non-diabetic subjects as a control group. Clinical parameters and medical history were recorded; fasting blood sampling was performed for biochemistry and for measuring serum IL-8, IL-6, TNF-α, CRP, adiponectin and 25(OH)vitamin D [25(OH)D] levels.

Results

Patients with T2D exhibited significantly higher serum IL-8 levels than non-diabetic subjects (69.27 ± 112.83 vs. 16.03 ± 24.27 pg/mL, p < 0.001). In diabetic patients, increased IL-8 concentration correlated with higher IL-6 (p < 0.001), TNF-α (p = 0.02), FBG (p = 0.035), HbA1c (p = 0.04) and LDL-C (p = 0.04) and with lower adiponectin (p = 0.02) and 25(OH)D (p = 0.003) concentrations.

Conclusions

Patients with T2D display a marked elevation of circulating IL-8 levels which identify subjects with worse inflammatory, glycometabolic and lipid profile and lower vitamin D levels. Further studies are warranted for evaluating a possible role of IL-8 as a novel marker for risk stratification in T2D patients.

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Funding

This study has been funded by research Grants from the Sapienza University Ateneo Scientific Research (MGC, IB).

Author information

Authors and Affiliations

  1. Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy

    F. A. Cimini, I. Barchetta, F. Mainiero, C. Costantino, L. Bertoccini, V. Ceccarelli, M. G. Baroni, A. Lenzi & M. G. Cavallo

  2. Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy

    A. Porzia

  3. Microscopic and Ultrastructural Anatomy (CIR), University Campus Bio-Medico, Rome, Italy

    S. Morini

Authors
  1. F. A. Cimini
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  2. I. Barchetta
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  3. A. Porzia
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  4. F. Mainiero
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  5. C. Costantino
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  6. L. Bertoccini
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  7. V. Ceccarelli
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  8. S. Morini
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  9. M. G. Baroni
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  10. A. Lenzi
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  11. M. G. Cavallo
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Corresponding author

Correspondence to M. G. Cavallo.

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Conflict of interest

The authors declare that they have no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

Ethical standard

All procedures performed in the study were in accordance with the ethical standards of the institutional (Sapienza University of Rome) and national research committee and with the 1964 Helsinki Declaration and its 2008 amendments.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Managed By Antonio Secchi.

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Cimini, F.A., Barchetta, I., Porzia, A. et al. Circulating IL-8 levels are increased in patients with type 2 diabetes and associated with worse inflammatory and cardiometabolic profile. Acta Diabetol 54, 961–967 (2017). https://doi.org/10.1007/s00592-017-1039-1

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  • DOI: https://doi.org/10.1007/s00592-017-1039-1

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