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Preoperatively determinable factors predictive of diabetes mellitus remission following Roux-en-Y gastric bypass: a review of the literature

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Abstract

It is well established that weight loss in general and bariatric surgery in particular can improve glycaemic control in diabetics. Current NICE guidelines recommend that those patients with type 2 diabetes mellitus and a BMI of 35 kg/m2 or more should be considered for bariatric surgery in order to optimise their glycaemic control and minimise their risk of long-term complications. The commonest bariatric procedure in the UK is the Roux-en-Y gastric bypass that has been shown to result in long-standing type 2 diabetes resolution in 83 % of patients. Since such surgery carries a small but significant risk of mortality, as well as posing considerable lifestyle implications for the patient, numerous studies have been performed with a view to identifying which patients and which procedures are most likely to result in these desired benefits. This paper summarises the existing literature on this topic.

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References

  1. Buchwald H, Estok R, Fahrbach K et al (2009) Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med 122(248–256):e245

    Google Scholar 

  2. Fobi MA (2010) P-119 Is the effect of gastric bypass on type 2 diabetes permanent? 27th Annual Meeting of the ASMBS, Las Vegas, Nevada, US, p s67

  3. Meijer RI, van Wagensveld BA, Siegert CE, Eringa EC, Serne EH, Smulders YM (2011) Bariatric surgery as a novel treatment for type 2 diabetes mellitus: a systematic review. Arch Surg 146:744–750

    Article  PubMed  Google Scholar 

  4. Buse JB, Caprio S, Cefalu WT et al (2009) How do we define cure of diabetes? Diabetes Care 32:2133–2135

    Article  PubMed  Google Scholar 

  5. Burcelin R, Serino M, Chabo C, Blasco-Baque V, Amar J (2011) Gut microbiota and diabetes: from pathogenesis to therapeutic perspective. Acta Diabetol 48:257–273

    Article  PubMed  Google Scholar 

  6. Amar J, Serino M, Lange C et al (2011) Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept. Diabetologia 54:3055–3061

    Article  PubMed  CAS  Google Scholar 

  7. Ishida RK, Faintuch J, Paula AM et al (2007) Microbial flora of the stomach after gastric bypass for morbid obesity. Obes Surg 17:752–758

    Article  PubMed  Google Scholar 

  8. Dixon JB, le Roux CW, Rubino F, Zimmet P (2012) Bariatric surgery for type 2 diabetes. Lancet 379:2300–2311

    Article  PubMed  Google Scholar 

  9. Pournaras DJ, Osborne A, Hawkins SC et al (2010) Remission of type 2 diabetes after gastric bypass and banding: mechanisms and 2 year outcomes. Ann Surg 252:966–971

    Article  PubMed  Google Scholar 

  10. Thaler JP, Cummings DE (2009) Minireview: hormonal and metabolic mechanisms of diabetes remission after gastrointestinal surgery. Endocrinology 150:2518–2525

    Article  PubMed  CAS  Google Scholar 

  11. Vetter ML, Ritter S, Wadden TA, Sarwer DB (2012) Comparison of bariatric surgical procedures for diabetes remission: efficacy and mechanisms. Diabetes Spectr 25:200–210

    Article  PubMed  Google Scholar 

  12. Frachetti KJ, Goldfine AB (2009) Bariatric surgery for diabetes management. Curr Opin Endocrinol Diabetes Obes 16:119–124

    Article  PubMed  Google Scholar 

  13. Herron DM, Tong W (2009) Role of surgery in management of type 2 diabetes mellitus. Mt Sinai J Med 76:281–293

    Article  PubMed  Google Scholar 

  14. Atkins RC, Zimmet P (2010) Diabetic kidney disease: act now or pay later. Acta Diabetol 47:1–4

    Article  PubMed  Google Scholar 

  15. Tarquini R, Lazzeri C, Pala L, Rotella CM, Gensini GF (2010) The diabetic cardiomyopathy. Acta Diabetol 48:173–181

    Article  PubMed  Google Scholar 

  16. Whiting DR, Guariguata L, Weil C, Shaw J (2011) IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 94:311–321

    Article  PubMed  Google Scholar 

  17. Pories WJ, Swanson MS, MacDonald KG et al (1995) Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus. Ann Surg 222:339–350 Discussion 350–332

    Article  PubMed  CAS  Google Scholar 

  18. Sjostrom L, Lindroos AK, Peltonen M et al (2004) Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med 351:2683–2693

    Article  PubMed  Google Scholar 

  19. Pournaras D, Aasheim E, Sovik T, et al. (2011) A05: Remission of Type 2 diabetes mellitus after bariatric surgery according to the 2009 American Diabetes Association Criteria. 28th Annual Meeting of the American Society for Metabolic and Bariatric Surgery, Orlando, Florida, US, pp 247–248

  20. Gagne DJ, Gill G, Urbandt J (2010) P-118: Improvement in Type 1 diabetes after laparoscopic Roux-en-Y gastric bypass. 27th Annual Meeting of the American Society for Metabolic and Bariatric Surgery, Las Vegas, Nevada, US, p S66

  21. Lee WJ, Chong K, Ser KH et al (2011) Gastric bypass vs sleeve gastrectomy for type 2 diabetes mellitus: a randomized controlled trial. Arch Surg 146:143–148

    Article  PubMed  Google Scholar 

  22. Boza C, Munoz R, Salinas J et al (2011) Safety and efficacy of Roux-en-Y gastric bypass to treat type 2 diabetes mellitus in non-severely obese patients. Obes Surg 21:1330–1336

    Article  PubMed  Google Scholar 

  23. Reis CE, Alvarez-Leite JI, Bressan J, Alfenas RC (2012) Role of bariatric-metabolic surgery in the treatment of obese type 2 diabetes with body mass index <35 kg/m(2): a literature review. Diabetes Technol Ther 14(4):365–372

  24. Hayes MT, Hunt LA, Foo J, Tychinskaya Y, Stubbs RS (2011) A model for predicting the resolution of type 2 diabetes in severely obese subjects following Roux-en Y gastric bypass surgery. Obes Surg 21:910–916

    Article  PubMed  Google Scholar 

  25. Hamza N, Abbas MH, Darwish A, Shafeek Z, New J, Ammori BJ (2011) Predictors of remission of type 2 diabetes mellitus after laparoscopic gastric banding and bypass. Surg Obes Relat Dis 7:691–696

    Article  PubMed  Google Scholar 

  26. Kadera BE, Lum K, Grant J, Pryor AD, Portenier DD, Demaria EJ (2009) Remission of type 2 diabetes after Roux-en-Y gastric bypass is associated with greater weight loss. Surg Obes Relat Dis 5:305–309

    Article  PubMed  Google Scholar 

  27. Lee WJ, Lee YC, Chen JC, Ser KH, Su YH, Chen SC (2010) Preoperative Predictors of Type 2 diabetes resolution after bariatric surgery 27th Annual meeting of the American society for metabolic and bariatric surgery. Surgery for obesity and related diseases. Las Vegas, Nevada, p S23

    Google Scholar 

  28. Hall TC, Pellen MG, Sedman PC, Jain PK (2010) Preoperative factors predicting remission of type 2 diabetes mellitus after Roux-en-Y gastric bypass surgery for obesity. Obes Surg 20:1245–1250

    Article  PubMed  Google Scholar 

  29. Maciejewski ML, Livingston EH, Kahwati LC, Henderson WG, Kavee AL, Arterburn DE (2010) Discontinuation of diabetes and lipid-lowering medications after bariatric surgery at veterans affairs medical centers. Surg Obes Relat Dis 6:601–607

    Article  PubMed  Google Scholar 

  30. Zeni T, Kapur S, Lark TR, Magid P (2009) Diabetes mellitus and insulin resolution after laparoscopic Roux-en-Y gastric bypass. 26th Annual Meeting of the American Society for Metabolic and Bariatric Surgery, Grapevine, Texas, USA, p S43

  31. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412–419

    Article  PubMed  CAS  Google Scholar 

  32. Perugini RA, Shah SA, Kelly JJ, Czerniach DR, Litwin DE, Gallagher-Dorval KA (2009) HOMA estimated glucose disposition index predicts resolution of type 2 diabetes mellitus following laparoscopic gastric bypass 26th Annual Meeting of the American Society for Metabolic and Bariatric Surgery. Surgery for Obesity and Related Diseases, Grapevine, Texas, USA, p S1

  33. Chikunguwo SM, Wolfe LG, Dodson P et al (2010) Analysis of factors associated with durable remission of diabetes after Roux-en-Y gastric bypass. Surg Obes Relat Dis 6:254–259

    Article  PubMed  Google Scholar 

  34. DiGiorgi M, Rosen DJ, Choi JJ et al (2010) Re-emergence of diabetes after gastric bypass in patients with mid- to long-term follow-up. Surg Obes Relat Dis 6:249–253

    Article  PubMed  Google Scholar 

  35. Deitel M (2009) Slow-progression, autoimmune, type 1 diabetes in adults: a cause of failure of resolution of diabetes after bariatric surgery. Surg Obes Relat Dis 5:705–706

    Article  PubMed  Google Scholar 

  36. Stenstrom G, Gottsater A, Bakhtadze E, Berger B, Sundkvist G (2005) Latent autoimmune diabetes in adults: definition, prevalence, beta-cell function, and treatment. Diabetes 54(Suppl 2):S68–S72

    Article  PubMed  Google Scholar 

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Correspondence to ST Adams.

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Communicated by Antonio Secchi.

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Adams, S., Salhab, M., Hussain, Z. et al. Preoperatively determinable factors predictive of diabetes mellitus remission following Roux-en-Y gastric bypass: a review of the literature. Acta Diabetol 50, 475–478 (2013). https://doi.org/10.1007/s00592-013-0453-2

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  • DOI: https://doi.org/10.1007/s00592-013-0453-2

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