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Impaired diffusing capacity for carbon monoxide in children with type 1 diabetes: is this the first sign of long-term complications?

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An Erratum to this article was published on 17 January 2012

Abstract

We assessed the presence of lung dysfunction in children with type 1 diabetes, evaluated as reduced diffusing capacity of the lung for carbon monoxide (DLCO), and its components: membrane diffusing capacity (DM) and pulmonary capillary blood volume (Vc). A total of 42 children, aged 15.6 ± 3.8 years, with type 1 diabetes for 8.3 ± 5.5 years, and 30 healthy age and sex-matched peers were recruited for the study. Lung volumes and spirometric dynamic parameters were assessed by plethysmography. Single-breath DLCO was measured according to international recommendation. DM and Vc volume were calculated. Lung volumes were significantly reduced in young patients with type 1 diabetes when compared to controls. Moreover, DLCO was reduced in patients compared to controls (78% ± 16% vs. 120% ± 1%, P = 0.0001). However, when differentiating DM and Vc compartments, we observed a significant impairment only about Vc (34 ± 20 ml vs. 88 ± 18 ml; P = 0.0001), while no difference was observed about DM compartment (23 ± 4 vs. 26 ± 3 ml/min/mmHg, P = 0.798). Whether this might be seen as the “first” sign of microangiopathic involvement in patients with type 1 diabetes has to be confirmed on larger groups but is still fascinating. Meanwhile, we suggest to screen DLCO in all patients with type 1 diabetes.

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Abbreviations

BMI:

Body mass index

DLCO:

Diffusing capacity of the lung for carbon monoxide

DM:

Membrane diffusing capacity

FEV1 :

Forced expiratory volume in 1 s

FVC:

Forced vital capacity

HbA1c:

Glycated hemoglobin

KCO:

Carbon monoxide transfer coefficient

RV:

Residual volume

TLC:

Total lung capacity

VC:

Vital capacity

Vc:

Pulmonary capillary blood volume

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Conflict of interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Paediatrics, “Luigi Sacco Hospital”, University of Milano, Via G.B. Grassi 74, 20157, Milan, Italy

    Andrea E. Scaramuzza, Marco Morelli, Simona Borgonovo, Alessandra De Palma, Chiara Mameli, Elisa Giani, Silvia Beretta & Gian Vincenzo Zuccotti

  2. Respiratory Medicine, Luigi Sacco Hospital, University of Milano, Via G.B. Grassi 74, 20157, Milan, Italy

    Maurizio Rizzi

  3. Department of Pediatrics, “Ospedale Luigi Sacco”, University of Milano, Via G.B. Grassi 64, 20154, Milan, Italy

    Andrea E. Scaramuzza

Authors
  1. Andrea E. Scaramuzza
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  2. Marco Morelli
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  3. Maurizio Rizzi
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  4. Simona Borgonovo
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  5. Alessandra De Palma
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  6. Chiara Mameli
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  7. Elisa Giani
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  8. Silvia Beretta
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  9. Gian Vincenzo Zuccotti
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Corresponding author

Correspondence to Andrea E. Scaramuzza.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s00592-011-0363-0.

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Scaramuzza, A.E., Morelli, M., Rizzi, M. et al. Impaired diffusing capacity for carbon monoxide in children with type 1 diabetes: is this the first sign of long-term complications?. Acta Diabetol 49, 159–164 (2012). https://doi.org/10.1007/s00592-011-0353-2

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  • DOI: https://doi.org/10.1007/s00592-011-0353-2

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