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Transcription factor 7-like 2-gene polymorphism is related to fasting C peptide in latent autoimmune diabetes in adults (LADA)

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Abstract

Common polymorphisms in the transcription factor 7-like 2 gene (TCF7L2) have been associated with type 2 diabetes in different populations and recently with LADA, but not with type 1 diabetes. The aim of our study was to investigate association between the rs7903146 polymorphism in the TCF7L2 gene and LADA in Polish patients. Link between the “high risk for type 2 diabetes genotype” with clinical features was analyzed. 68 newly diagnosed patients with LADA and 195 healthy controls were genotyped for the rs7903146 polymorphism in the TCF7L2 gene using the PCR-based RFLP method. Fasting C peptide level was measured by ELISA. We observed increased frequencies of the TT genotype of the rs7903146 polymorphism in the TCF7L2 gene in LADA patients compared to controls (15 vs. 6%, P = 0.03). Fasting C peptide serum concentration was significantly lower in group of patients with LADA carrying the TT genotype (P < 0.01). In conclusion, the data from this study confirmed previous results showing genetic similarities between patients with LADA and type 2 diabetes. Non-autoimmune mechanism may be related to beta cell dysfunction in patients with LADA.

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Authors and Affiliations

  1. Section of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA

    Barbara Szepietowska

  2. Department of Internal Medicine and Nephrodiabetology, Medical University of Lodz, Lodz, Poland

    Dariusz Moczulski

  3. Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Białystok, Poland

    Barbara Szepietowska, Natalia Wawrusiewicz-Kurylonek, Maria Gorska & Malgorzata Szelachowska

  4. Department of Internal Medicine, Diabetology and Nephrology in Zabrze, Silesian School of Medicine in Katowice, Katowice, Poland

    Wladyslaw Grzeszczak

Authors
  1. Barbara Szepietowska
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  2. Dariusz Moczulski
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  3. Natalia Wawrusiewicz-Kurylonek
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  4. Wladyslaw Grzeszczak
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  5. Maria Gorska
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  6. Malgorzata Szelachowska
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Correspondence to Barbara Szepietowska.

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Szepietowska, B., Moczulski, D., Wawrusiewicz-Kurylonek, N. et al. Transcription factor 7-like 2-gene polymorphism is related to fasting C peptide in latent autoimmune diabetes in adults (LADA). Acta Diabetol 47, 83–86 (2010). https://doi.org/10.1007/s00592-009-0133-4

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  • DOI: https://doi.org/10.1007/s00592-009-0133-4

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