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Risk factors of new symptomatic vertebral compression fractures in osteoporotic patients undergone percutaneous vertebroplasty

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Abstract

Purpose

This study evaluated the risk factors of new vertebral compression fractures (VCFs) following percutaneous vertebroplasty (PVP).

Methods

From June 2005 to January 2011, patients with osteoporotic VCFs (OVCFs) who were treated with PVP and met this study’s inclusion criteria were retrospectively reviewed. Observed parameters were age, sex, bone mineral density, body mass index, amount of bone cement, cement leakage into the disk, preoperative kyphosis, preoperative degree of anterior vertebral compression, preoperative degree of middle vertebral compression, kyphosis correction, anterior vertebral height restoration, middle vertebral height restoration, and number of initial symptomatic fractures (levels treated). The data were analyzed by univariate and multivariate analysis for the emergence of new fractures after PVP to determine related risk factors.

Results

A total of 182 patients met the inclusion criteria. There were 155 female and 27 male patients with a mean age of 69.7 years (range 49–91 years). The follow-up period was 24–50 months (average 26.4 months). A total of 294 VCFs among 182 patients were observed, 28 new VCFs occurred in 21 patients (21/182, 11.5 %) during the follow-up period. Statistical analysis indicated that higher BMI (P = 0.004) and a greater number of initial symptomatic fractures (P = 0.017) were significantly associated with new VCFs after PVP. It is the most obvious that the risk of new fractures increased 2.518-fold (95 % CI 1.176–5.395), when the number of initial VCFs increased by one level.

Conclusions

The incidence of new symptomatic VCFs after PVP was higher in osteoporotic patients with initial multiple-level fractures.

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Acknowledgments

We would like to extend our sincere gratitude to Professor Zhu Qingan for his instructive advice and useful suggestions during the writing of this article.

Conflict of interest

None.

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Authors and Affiliations

  1. Department of Spine Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China

    Hai-long Ren, Jian-ming Jiang, Jian-ting Chen & Ji-xing Wang

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  1. Hai-long Ren
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  2. Jian-ming Jiang
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Correspondence to Hai-long Ren or Ji-xing Wang.

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Ren, Hl., Jiang, Jm., Chen, Jt. et al. Risk factors of new symptomatic vertebral compression fractures in osteoporotic patients undergone percutaneous vertebroplasty. Eur Spine J 24, 750–758 (2015). https://doi.org/10.1007/s00586-015-3786-4

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  • DOI: https://doi.org/10.1007/s00586-015-3786-4

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