Skip to main content

Advertisement

SpringerLink
Log in

Risk factors of developing new symptomatic vertebral compression fractures after percutaneous vertebroplasty in osteoporotic patients

  • Original Article
  • Published:
European Spine Journal Aims and scope Submit manuscript

Abstract

Percutaneous vertebroplasty (PVP) is an efficient procedure to treat pain due to osteoporotic vertebral compression fractures (OVCFs). However, some patient populations experience recurrent vertebral fracture after initial successful procedure. There are a lot of literatures about the effectiveness of this procedure but few concerning the development of recurrent, new compression fracture. This is a retrospective review of all PVPs performed in author’s institution from September 1999 to December 2001 to investigate the factors related to the development of new symptomatic OVCFs after PVPs. A retrospective review of 244 cases of PVP for symptomatic OVCFs at 382 levels was performed. Sociodemographic, clinical, radiologic, and procedural data were analyzed and compared between the two patient groups (control group : no further symptomatic OVCFs after the initial PVP, “new symptomatic fracture” group: with newly developed symptomatic OVCF). Statistical analysis was performed between the variables of the two groups. Survival analysis was performed using the Kaplan–Meier method. Over all, 38 among 244 treated patients (15.6%) had experienced newly developed symptomatic OVCF(s) during the follow up period (mean 52.5 months). Old age and the presence of multiple treated vertebrae at the initial PVP were assessed as a strong parameter for predicting new symptomatic OVCF. With increasing preoperative wedging deformity the risk of developing new symptomatic OVCF decreased. The Kaplan-Meier estimate of the 1 year fracture-free rate was 92.2%. The Kaplan–Meier curve showed that 7.8% of the patients would experience new symptomatic OVCF within 1 year after initial PVP. A preoperative only mild wedge deformity of the fractured vertebra(e) could indicate the increased risk of developing new symptomatic OVCF after vertebroplasty.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Amar AP, Larsen DW, Esnaashari N, Albuquerque FC, Lavine SD, Teitelbaum GP (2001) Percutaneous transpedicular polymethylmethacrylate vertebroplasty for the treatment of spinal compression fractures. Neurosurgery 49:1105–1114

    Article  PubMed  CAS  Google Scholar 

  2. Berlemann U, Ferguson SJ, Nolte LP, Heini PF (2002) Adjacent vertebral failure after vertebroplasty. A biomechanical investigation. J Bone Joint Surg Br 84:748–752

    Article  PubMed  CAS  Google Scholar 

  3. Cohen JE, Lylyk P, Ceratto R, Kaplan L, Umanskyt F, Gomori JM (2004) Percutaneous vertebroplasty: technique and results in 192 procedures. Neurol Res 26:41–49

    Article  PubMed  Google Scholar 

  4. Deramond H, Depriester C, Galibert P, Le GD (1998) Percutaneous vertebroplasty with polymethylmethacrylate.Technique, indications, and results. Radiol Clin North Am 36:533–546

    Article  PubMed  CAS  Google Scholar 

  5. Diamond TH, Champion B, Clark WA (2003) Management of acute osteoporotic vertebral fractures: a nonrandomized trial comparing percutaneous vertebroplasty with conservative therapy. Am J Med 114:257–265

    Article  PubMed  Google Scholar 

  6. Fourney DR, Schomer DF, Nader R, Chlan-Fourney J, Suki D, Ahrar K, Rhines LD, Gokaslan ZL (2003) Percutaneous vertebroplasty and kyphoplasty for painful vertebral body fractures in cancer patients. J Neurosurg 98:21–30

    PubMed  Google Scholar 

  7. Garfin SR, Yuan HA, Reiley MA (2001) New technologies in spine: kyphoplasty and vertebroplasty for the treatment of painful osteoporotic compression fractures. Spine 26:1511–1515

    Article  PubMed  CAS  Google Scholar 

  8. Grados F, Depriester C, Cayrolle G, Hardy N, Deramond H, Fardellone P (2000) Long-term observations of vertebral osteoporotic fractures treated by percutaneous vertebroplasty. Rheumatology (Oxford) 39:1410–1414

    Article  CAS  Google Scholar 

  9. Guglielmi G, Andreula C, Muto M, Gilula LA (2005) Percutaneous vertebroplasty: indications, contraindications, technique, and complications. Acta Radiol 46:256–268

    Article  PubMed  CAS  Google Scholar 

  10. Hardouin P, Grados F, Cotten A, Cortet B (2001) Should percutaneous vertebroplasty be used to treat osteoporotic fractures? An update. Joint Bone Spine 68:216–221

    Article  PubMed  CAS  Google Scholar 

  11. Heini PF, Berlemann U (2001) Bone substitutes in vertebroplasty. Eur Spine J 10 Suppl 2:S205–S213

    Google Scholar 

  12. Kim SH, Kang HS, Choi JA, Ahn JM (2004) Risk factors of new compression fractures in adjacent vertebrae after percutaneous vertebroplasty. Acta Radiol 45:440–445

    Article  PubMed  CAS  Google Scholar 

  13. Kremer MA, Fruin A, Larson TC III, Roll J, Weil RJ (2003) Vertebroplasty in focal Paget disease of the spine. Case report. J Neurosurg 99:110–113

    PubMed  Google Scholar 

  14. Legroux-Gerot I, Lormeau C, Boutry N, Cotten A, Duquesnoy B, Cortet B (2004) Long-term follow-up of vertebral osteoporotic fractures treated by percutaneous vertebroplasty. Clin Rheumatol 23:310–317

    Article  PubMed  Google Scholar 

  15. Lindsay R, Silverman SL, Cooper C, Hanley DA, Barton I, Broy SB, Licata A, Benhamou L, Geusens P, Flowers K, Stracke H, Seeman E (2001) Risk of new vertebral fracture in the year following a fracture. JAMA 285:320–323

    Article  PubMed  CAS  Google Scholar 

  16. Mehbod A, Aunoble S, Le Huec JC (2003) Vertebroplasty for osteoporotic spine fracture: prevention and treatment. Eur Spine J 12 Suppl 2:S155–S162

    Article  Google Scholar 

  17. Moreland DB, Landi MK, Grand W (2001) Vertebroplasty: techniques to avoid complications. Spine J 1:66–71

    Article  PubMed  CAS  Google Scholar 

  18. Nakano M, Hirano N, Ishihara H, Kawaguchi Y, Matsuura K (2005) Calcium phosphate cement leakage after percutaneous vertebroplasty for osteoporotic vertebral fractures: risk factor analysis for cement leakage. J Neurosurg Spine 2:27–33

    Article  PubMed  Google Scholar 

  19. Nakano M, Hirano N, Matsuura K, Watanabe H, Kitagawa H, Ishihara H, Kawaguchi Y (2002) Percutaneous transpedicular vertebroplasty with calcium phosphate cement in the treatment of osteoporotic vertebral compression and burst fractures. J Neurosurg 97:287–293

    PubMed  Google Scholar 

  20. Peh WC, Gilula LA, Peck DD (2002) Percutaneous vertebroplasty for severe osteoporotic vertebral body compression fractures. Radiology 223:121–126

    PubMed  Google Scholar 

  21. Teng MM, Wei CJ, Wei LC, Luo CB, Lirng JF, Chang FC, Liu CL, Chang CY (2003) Kyphosis correction and height restoration effects of percutaneous vertebroplasty. AJNR Am J Neuroradiol 24:1893–1900

    PubMed  Google Scholar 

  22. Truumees E, Hilibrand A, Vaccaro AR (2004) Percutaneous vertebral augmentation. Spine J 4:218–229

    Article  PubMed  Google Scholar 

  23. Uppin AA, Hirsch JA, Centenera LV, Pfiefer BA, Pazianos AG, Choi IS (2003) Occurrence of new vertebral body fracture after percutaneous vertebroplasty in patients with osteoporosis. Radiology 226:119–124

    PubMed  Google Scholar 

  24. Wilson DR, Myers ER, Mathis JM, Scribner RM, Conta JA, Reiley MA, Talmadge KD, Hayes WC (2000) Effect of augmentation on the mechanics of vertebral wedge fractures. Spine 25:158–165

    Article  PubMed  CAS  Google Scholar 

  25. Winking M, Stahl JP, Oertel M, Schnettler R, Boker DK (2004) Treatment of pain from osteoporotic vertebral collapse by percutaneous PMMA vertebroplasty. Acta Neurochir (Wien) 146:469–476

    Article  CAS  Google Scholar 

  26. Yamada K, Matsumoto Y, Kita M, Yamamoto K, Kobayashi T, Takanaka T (2004) Long-term pain relief effects in four patients undergoing percutaneous vertebroplasty for metastatic vertebral tumor. J Anesth 18:292–295

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Neurosurgery, 21st Century Hospital, , Seoul, Korea

    Wan Soo Lee, Kyeong Hoon Sung, Hyun Tae Jeong, Youn Sang Sung, Yong In Hyun, Jae Young Choi & Kyu Seok Lee

  2. Diagnostic Radiology, 21st Century Hospital, Seoul, Korea

    Chul Su Ok & Young Woo Choi

Authors
  1. Wan Soo Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kyeong Hoon Sung
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hyun Tae Jeong
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Youn Sang Sung
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yong In Hyun
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jae Young Choi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Kyu Seok Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Chul Su Ok
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Young Woo Choi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Wan Soo Lee.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lee, W.S., Sung, K.H., Jeong, H.T. et al. Risk factors of developing new symptomatic vertebral compression fractures after percutaneous vertebroplasty in osteoporotic patients. Eur Spine J 15, 1777–1783 (2006). https://doi.org/10.1007/s00586-006-0151-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00586-006-0151-7

Keywords

Search

Navigation