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Ultra-short-course chemotherapy for spinal tuberculosis: five years of observation

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Abstract

Purpose

This study aimed to explore the feasibility of ultra-short-course chemotherapy in the treatment of spinal tuberculosis.

Methods

One hundred and eighty-five patients with confirmed spinal tuberculosis and surgical indication were included. The chemotherapy regimen was 2SHRZ/XHRZ. According to the duration of the chemotherapy, the patients were divided into two groups, the ultra-short-course chemotherapy group with an average duration of 4.5 months, and the standard chemotherapy group with an average duration of 9 months. The same surgery was performed for patients in the two groups.

Results

The duration of the follow-up ranged from 61 to 87 months, with an average of 69.1 months. Erythrocyte sedimentation rate and C-reactive protein, kyphosis and nerve function, recovery of work, and activities of daily living were not significantly different between the two groups before or after treatment; however, the aforementioned indices were significantly different before and after treatment within groups. There was no significant difference in postoperative bone graft healing between the two groups. The drug side effects were significantly different between the two groups.

Conclusions

With thorough focus debridement, bone grafting, and internal fixation, the efficacy of ultra-short chemotherapy was similar to that of standard chemotherapy for the treatment of spinal tuberculosis. The ultra-short-course chemotherapy can shorten the course of treatment and reduce drug side effects.

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Authors and Affiliations

  1. Department of Spine Surgery, General Hospital of Ningxia Medical University, No. 804, Shengli Street, Yinchuan 750004, Ningxia, China

    Zili Wang, Jiandang Shi & Guangqi Geng

  2. The School of Public Health of Ningxia Medical University, No. 804, Shengli Street, Yinchuan 750004, Ningxia, China

    Hongyan Qiu

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  1. Zili Wang
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  2. Jiandang Shi
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  3. Guangqi Geng
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  4. Hongyan Qiu
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Correspondence to Jiandang Shi.

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Wang, Z., Shi, J., Geng, G. et al. Ultra-short-course chemotherapy for spinal tuberculosis: five years of observation. Eur Spine J 22, 274–281 (2013). https://doi.org/10.1007/s00586-012-2536-0

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  • DOI: https://doi.org/10.1007/s00586-012-2536-0

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