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End Point of Chemotherapy for TB Spine?

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Tuberculosis of the Spine

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Abstract

Tuberculosis is a major health problem in developing countries, and India is considered endemic for the disease. The management of spinal tuberculosis has come to a full circle. It has evolved drastically from an era of conservative treatment due to lack of good surgical techniques to an era of aggressive surgery with anterior reconstructions and now back to conservative treatment with better availability of diagnostic methods and superior understanding of the microbiology of the bug and the pharmacology of drugs.

Spinal tuberculosis is essentially a medical disease. Successful outcome of spinal tuberculosis relies on accurate histopathological and microbiological diagnosis, appropriate chemotherapeutic regimens, and optimum monitoring.

Though the chemotherapeutic regimen for sensitive TB is largely accepted, no consensus has been reached on appropriate duration of anti-tubercular drugs, as there has been no accepted definition of “healed status” in spinal TB.

In most studies, the duration of chemotherapy varies from 6 months to 12 months.

The end point of treatment is based on combination of clinical, radiological, and laboratory parameters, but the lack of hard criteria to define healed spinal TB keep the controversy about the duration of AKT alive.

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Authors and Affiliations

  1. WeareSpine, Lilavati Hospital and Research Centre, Mumbai, India

    Abhay Nene & Munjal Shah

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  1. Abhay Nene
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  2. Munjal Shah
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Correspondence to Abhay Nene .

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Editors and Affiliations

  1. Department of Orthopaedics, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India

    Sarvdeep Singh Dhatt

  2. Department of Orthopaedics, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India

    Vishal Kumar

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Nene, A., Shah, M. (2022). End Point of Chemotherapy for TB Spine?. In: Dhatt, S.S., Kumar, V. (eds) Tuberculosis of the Spine. Springer, Singapore. https://doi.org/10.1007/978-981-16-9495-0_28

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  • DOI: https://doi.org/10.1007/978-981-16-9495-0_28

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-16-9494-3

  • Online ISBN: 978-981-16-9495-0

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