Abstract
This paper proposes a simple and rapid fabrication of a glucose sensor based on inkjet printing method. A commercially available inkjet printer is used to print carbon nanotubes and polyaniline nanowires for patterning low sheet resistance electrodes and a chemiresistive glucose sensing area, respectively. Enzyme glucose oxidase, in conjunction with platinum nanoparticles were also incorporated into the chemiresistive sensor to generate a two-step catalytic process: in the first step, glucose is catalyzed by the oxidase to produce hydrogen peroxide as a byproduct, and in the second step, platinum nanoparticles catalyze hydrogen peroxide to produce hydroxide ions which causes a local pH change near the site of reaction. Since the conductivity of polyaniline is known to be pH-responsive, the polyaniline layer serves as a chemiresistive sensor to detect the H2O2 concentration which subsequently leads to the quantification of the glucose concentration. The developed inkjet-printed glucose sensor was able to achieve a detection limit of 2 mM and a good linear relationship between current measurements and glucose concentration was obtained. The results indicate that the proposed method to print a simple, rapid, and disposable glucose sensing device can lead to the development of an on-demand printable point-of-care diagnostic kit for glucose measurement.
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Acknowledgments
This work was supported in part by the Fund for Innovation in Engineering Research, Economic Development Assistantship from Louisiana State University, and the CAPES Science without Borders Scholarship from the Ministry of Education of Brazil.
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Song, E., da Costa, T.H. & Choi, JW. A chemiresistive glucose sensor fabricated by inkjet printing. Microsyst Technol 23, 3505–3511 (2017). https://doi.org/10.1007/s00542-016-3160-4
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DOI: https://doi.org/10.1007/s00542-016-3160-4