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The efficacy of pregabalin for prevention of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled double-blind study

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Abstract

Objective

The present study evaluated the efficacy of preoperative pregabalin for prevention of catheter-related bladder discomfort.

Design

Prospective, randomized, placebo controlled, double blinded study.

Materials and methods

Sixty patients of either sex undergoing elective spine surgery and requiring urinary bladder catheterization were randomly assigned to two groups. The patients in Group P (pregabalin group) received 150 mg of pregabalin orally 1 h prior to induction of anesthesia with sips of water and the patients in Group C (control group) received placebo. Anesthesia technique was identical in both the groups. Catheter-related bladder discomfort (CRBD) was evaluated on a 4-point scale (1 = no discomfort, 2 = mild, 3 = moderate, 4 = severe), on arrival (0 h) and again at 1, 2, and 6 h postoperatively. Patients were provided patient-controlled analgesia with fentanyl for postoperative pain relief.

Results

The incidence of CRBD was significantly less in the pregabalin group compared with the control group at all time intervals (P < 0.05). The severity of CRBD was reduced in the pregabalin group compared with the control group at all time intervals except 6 h. The postoperative consumption of fentanyl was significantly less in group P, while the sedation score was significantly higher in the group P compared to group C.

Conclusion

Pretreatment with pregabalin 150 mg prevents CRBD and also decreases postoperative fentanyl consumption. Clinical Trials.gov identifier: (ref: CTRI/2013/11/004170).

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Authors and Affiliations

  1. Department of Anesthesia, Apollo Hospitals, Bilaspur, 495006, Chhattisgarh, India

    Vinit K. Srivastava, Venkat N. Kadiyala & Mukadder Ahmed

  2. Department of Anesthesia, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India

    Sanjay Agrawal

  3. Department of Neurosurgery, Apollo Hospitals, Bilaspur, Chhattisgarh, India

    Sunil Sharma & Raj Kumar

Authors
  1. Vinit K. Srivastava
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  2. Sanjay Agrawal
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  3. Venkat N. Kadiyala
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  4. Mukadder Ahmed
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  5. Sunil Sharma
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  6. Raj Kumar
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Corresponding author

Correspondence to Vinit K. Srivastava.

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Srivastava, V.K., Agrawal, S., Kadiyala, V.N. et al. The efficacy of pregabalin for prevention of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled double-blind study. J Anesth 29, 212–216 (2015). https://doi.org/10.1007/s00540-014-1911-x

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  • DOI: https://doi.org/10.1007/s00540-014-1911-x

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