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Primary non-Hodgkin’s lymphoma of the main hepatic duct junction

  • Case Report of Interest
  • Published:
Journal of Hepato-Biliary-Pancreatic Surgery

Abstract

A rare case of primary non-Hodgkin’s lymphoma of the main hepatic duct junction is reported. A 71-year-old man was admitted for treatment of obstructive jaundice. Radiological examination revealed stenosis of the main hepatic duct junction. Biliary drainage was not necessary because total bilirubin decreased spontaneously. A left hepatic and caudate lobectomy, combined with resection of bile ducts and lymph node dissection, was performed with the preoperative diagnosis of cholangiocarcinoma of the main hepatic duct junction. Macroscopic examination of the resected specimen revealed tumorous growth in the main hepatic duct junction. Histological and immunochemistry findings disclosed a mucosaassociated lymphoid tissue (MALT) lymphoma. The patient received three courses of combination chemotherapy [cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP)], and there was no evidence of recurrence 45 months after the surgery. Although primary non-Hodgkin’s lymphoma of the main hepatic duct junction is extremely rare and difficult to diagnose preoperatively, aggressive surgery followed by chemotherapy, as here, is a possible curative option.

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References

  1. Fidias P, Carey RW, Grossbard ML. Non-Hodgkin’s lymphoma presenting with biliary tract obstruction. A discussion of seven patients and a review of the literature. Cancer 1995;75:1669–1677.

    Article  PubMed  CAS  Google Scholar 

  2. Ravindra KV, Stringer MD, Prasad KR, Kinsey SE, Lodge JP. Non-Hodgkin lymphoma presenting with obstructive jaundice. Br J Surg 2003;90:845–849.

    Article  PubMed  CAS  Google Scholar 

  3. Suzuki S, Tanaka S, Suzuki M, Imazato M, Hayashi T, Hanyu F, et al. Mucosa-associated lymphoid tissue-type lymphoproliferative lesion of the common bile duct. Hepatogastroenterology 2004;51:110–113.

    PubMed  Google Scholar 

  4. Shimura T, Kuwano H, Kashiwabara K, Kojima M, Masuda N, Suzuki H, et al. Mucosa-associated lymphoid tissue lymphoma of the extrahepatic bile duct. Hepatogastroenterology 2005;52:360–362.

    PubMed  Google Scholar 

  5. Brouland JP, Molimard J, Nemeth J, Valleur P, Galian A. Primary T-cell rich B-cell lymphoma of the common bile duct. Virchows Arch A Pathol Anat Histopathol 1993;423:513–517.

    Article  PubMed  CAS  Google Scholar 

  6. Tsushimi T, Enoki T, Harada E, Orita M, Noshima S, Masuda M, et al. Ectopic hepatocellular carcinoma arising in the bile duct. J Hepatobiliary Pancreat Surg 2005;12:266–268.

    Article  PubMed  Google Scholar 

  7. Kadono J, Hamada N, Higashi M, Ishizaki N, Nakamura N, Sakata R. Carcinosarcoma of the extrahepatic bile duct. J Hepatobiliary Pancreat Surg 2005;12:328–331.

    Article  PubMed  Google Scholar 

  8. Sugiura Y, Nakamura S, Iida S, Hosoda Y, Ikeuchi S, Mori S, et al. Extensive resection of the bile ducts combined with liver resection for cancer of the main hepatic duct junction: a cooperative study of the Keio Bile Duct Cancer Study Group. Surgery 1994;115:445–451.

    PubMed  CAS  Google Scholar 

  9. Nguyen GK. Primary extranodal non-Hodgkin’s lymphoma of the extrahepatic bile ducts. Report of a case. Cancer 1982;50:2218–2222.

    Article  PubMed  CAS  Google Scholar 

  10. Kosuge T, Makuuchi M, Ozaki H, Kinoshita T, Takenaka T, Mukai K. Primary lymphoma of the common bile duct. Hepatogastroenterology 1991;38:235–238.

    PubMed  CAS  Google Scholar 

  11. Maymind M, Mergelas JE, Seibert DG, Hostetter RB, Chang WW. Primary non-Hodgkin’s lymphoma of the common bile duct. Am J Gastroenterol 1997;92:1543–1546.

    PubMed  CAS  Google Scholar 

  12. Dudgeon DJ, Brower M. Primary chemotherapy for obstructive jaundice caused by intermediate-grade non-Hodgkin lymphoma. Cancer 1993;71:2813–2816.

    Article  PubMed  CAS  Google Scholar 

  13. Das K, Fisher A, Wilson DJ, dela Torre AN, Seguel J, Koneru B. Primary non-Hodgkin’s lymphoma of the bile ducts mimicking cholangiocarcinoma. Surgery 2003;134:496–500.

    Article  PubMed  Google Scholar 

  14. Joo YE, Park CH, Lee WS, Kim HS, Choi SK, Cho CK, et al. Primary non-Hodgkin’s lymphoma of the common bile duct presenting as obstructive jaundice. J Gastroenterol 2004;39:692–696.

    Article  PubMed  Google Scholar 

  15. Gravel J, Lallier M, Garel L, Brochu P, Champagne J, Alvarez F. Primary non-Hodgkin lymphoma of the extrahepatic biliary tract and gallbladder in a child. J Pediatr Gastroenterol Nutr 2001;32:598–601.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, Kawasaki Municipal Hospital, 12-1 Shinkawadori, Kawasaki-ku, Kawasaki, Kanagawa, 210-0013, Japan

    Masaya Shito, Toshihiro Kakefuda, Tai Omori & Seiichiro Ishii

  2. Department of Pathology, Kawasaki Municipal Hospital, Kawasaki, Japan

    Hitoshi Sugiura

Authors
  1. Masaya Shito
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  2. Toshihiro Kakefuda
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  3. Tai Omori
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  4. Seiichiro Ishii
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  5. Hitoshi Sugiura
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Shito, M., Kakefuda, T., Omori, T. et al. Primary non-Hodgkin’s lymphoma of the main hepatic duct junction. J Hepatobiliary Pancreat Surg 15, 440–443 (2008). https://doi.org/10.1007/s00534-007-1229-2

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  • DOI: https://doi.org/10.1007/s00534-007-1229-2

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