Abstract
A rare case of a carcinosarcoma of the extrahepatic bile duct demonstrating interesting features is described. A 75-year-old woman with a history of choledocholithotomy presented with acute obstructive suppurative cholangitis. Ultrasonography and computed tomography showed a thickened choledochal wall, with calcification. Percutaneous transhepatic and endoscopic retrograde cholangiography revealed a round filling defect accompanied by an irregular obstruction in the common bile duct. Carcinosarcoma was diagnosed from a protruding lesion in the common bile duct obtained by intraoperative frozen sectioning, and pylorus-preserving pancreatoduodenectomy was performed. Histological examination by light microscopy showed a transition between the carcinomatous and sarcomatous components and positive immunoreactivity for epithelial markers in the sarcomatous component. The patient died of a local recurrence 2 years after the surgery. Polypoid growth and ossification in the tumor could be representative features of carcinosarcoma of the extrahepatic bile duct.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
PA Loud DM Warshauer JT Woosley TM Hartmann (1997) ArticleTitleCarcinosarcoma of the extrahepatic bile ducts: cholangiographic and CT appearance Abdom Imaging 22 85–6 Occurrence Handle10.1007/s002619900146 Occurrence Handle9000363
S Inoshita A Iwashita M Enjoji (1986) ArticleTitleCarcinosarcoma of the gallbladder. Report of a case and review of the literature Acta Pathol Jpn 36 913–20 Occurrence Handle3766137
S Iyomasa H Kato Y Tachimori H Watanabe H Yamaguchi M Itabashi (1990) ArticleTitleCarcinosarcoma of the esophagus: a twenty-case study Jpn J Clin Oncol 20 99–106 Occurrence Handle2319703
T Nakagawa K Yamakado K Takeda T Nakagawa (1996) ArticleTitleAn ossifying carcinosarcoma of the gallbladder: radiologic findings AJR Am J Roentgenol 166 1233–4 Occurrence Handle8615287
H Kijima T Takeshita H Suzuki T Tanahashi A Suto H Izumika et al. (1999) ArticleTitleCarcinosarcoma of the ampulla of Vater: a case report with immunohistochemical and ultrastructural studies Am J Gastroenterol 94 3055–9 Occurrence Handle10.1111/j.1572-0241.1999.01461.x Occurrence Handle10520870
L Thompson B Chang SH Barsky (1996) ArticleTitleMonoclonal origins of malignant mixed tumors (carcinosarcomas): evidence for a divergent histogenesis Am J Surg Pathol 20 277–85 Occurrence Handle10.1097/00000478-199603000-00003 Occurrence Handle8772780
MR Wick PE Swanson (1993) ArticleTitleCarcinosarcoma: current perspectives and an historical review of nosological concepts Semin Diagn Pathol 10 118–27 Occurrence Handle8367621
T Iwaya C Maesawa G Tamura N Sato K Ikeda A Sasaki et al. (1997) ArticleTitleEsophageal carcinosarcoma: a genetic analysis Gastroenterology 113 973–7 Occurrence Handle9287991
MA Harris LM Delap PS Sengupta PM Wilkinson RS Welch R Swindell et al. (2003) ArticleTitleCarcinosarcoma of the ovary Br J Cancer 88 654–7 Occurrence Handle10.1038/sj.bjc.6600770 Occurrence Handle12618869
K Uesaka Y Nimura N Hayakawa S Iyomasa S Kondo M Nagino et al. (1995) ArticleTitleCarcinosarcoma of the gallbladder: a case report and review of the literature J Hepatobiliary Pancreat Surg 2 446–50
Author information
Authors and Affiliations
About this article
Cite this article
Kadono, J., Hamada, N., Higashi, M. et al. Carcinosarcoma of the extrahepatic bile duct. J Hepatobiliary Pancreat Surg 12, 328–331 (2005). https://doi.org/10.1007/s00534-005-0988-x
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s00534-005-0988-x