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Dysnatraemias in the emergency room: Undetected, untreated, unknown?

Dysnatriämien an der Notfallaufnahme: Unentdeckt, unbehandelt, unbekannt?

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Zusammenfassung

HINTERGRUND: Hypo- und Hypernatriämie sind die häufigsten Elektrolytstörungen im Krankenhaus und wurden mit erhöhter Mortalität assoziiert. Zur Zeit gibt es nur wenige Daten zur Prävalenz der Dysnatriämien an der Notfallaufnahme sowie zu den Charakteristika der Patienten mit Hypo- und Hypernatriämien. METHODIK: In diese retrospektive Studie wurden Patienten welche zwischen 01.09.2010 und 30.11.2010 an der Notfallaufnahme einer Universitätsklinik eine Bestimmung des Serum-Natriums erhielten eingeschlossen. RESULTATE: Insgesamt wurden während des Studienzeitraumes an 3.182 Patienten Bestimmungen des Serum-Natriums durchgeführt. 124 Patienten (4 %) wiesen bei Aufnahme in die Notfallaufnahme eine Hyponatriämie auf, während 400 Patienten (13 %) eine Hypernatriämie aufwiesen. Es zeigte sich kein Unterschied im Alter zwischen jenen Patienten welche eine Hypernatriämie aufwiesen und jenen welche normonaträm waren. Patienten mit Hyponatriämie waren hingegen signifikant älter. SCHLUSSFOLGERUNGEN: Beinahe 1 von 5 Patienten weist bei Aufnahme an der Notfallaufnahme eine Störung des Natriumhaushalts auf. Im Gegensatz zu hospitalisierten Patienten war an der Notfallaufnahme die Prävalenz der Hypernatriämie bedeutend grösser als jene der Hyponatriämie. Überraschenderweise waren Patienten mit Hyponatriämie signifikant älter als jene mit Hypernatriämie und jene mit normalen Serum-Natriumwerten.

Summary

BACKGROUND: Hypo- and hypernatraemia are the most common electrolyte disorders in hospitalized patients and have been associated with increased mortality. However, data on the prevalence of dysnatraemias in the emergency room and the characteristics of patients presenting with them are rare. METHODS: In this retrospective study, we analyzed data from patients who presented to the emergency department of a large tertiary university hospital between September 1st 2010 and November 30th 2010 and who received measurement of serum sodium. RESULTS: 3,182 patients received measurement of serum sodium during the three-month study period. 124 patients (4%) presented with hyponatraemia on admission to the emergency department while 400 patients (13%) presented with hypernatraemia. While there was no difference in age between patients with hypernatraemia and those who were normonatraemic, patients with hyponatraemia were significantly older. CONCLUSION: Dysnatraemias are present in almost 1 in 5 patients who presented to the emergency department. Contrarily to patients who are already hospitalized, hypernatraemia was by far more common than hyponatraemia in patients at the emergency department. Surprisingly, patients with hyponatraemia were significantly older than normonatraemic patients while there was no age difference in hypernatraemic patients. Dysnatraemias are common in the emergency room and further studies are indicated to evaluate the causes and the impact on outcome of patients.

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References

  • Funk GC, Lindner G, Druml W, et al. Incidence and prognosis of dysnatremias present on ICU admission. Intensive Care Med 2010;36:304–11

    Article  PubMed  Google Scholar 

  • Renneboog B, Musch W, Vandemergel X, Manto MU, Decaux G. Mild chronic hyponatremia is associated with falls, unsteadiness, and attention deficits. Am J Med 2006;119:71 e1–8

    Article  Google Scholar 

  • Verbalis JG, Barsony J, Sugimura Y, et al. Hyponatremia-induced osteoporosis. J Bone Miner Res;25:554–63

    Article  Google Scholar 

  • Hoorn EJ, Rivadeneira F, van Meurs JB, et al. Mild hyponatremia as a risk factor for fractures: The Rotterdam Study. J Bone Miner Res 2011;26(8):1822–8

    Article  PubMed  CAS  Google Scholar 

  • Kinsella S, Moran S, Sullivan MO, Molloy MG, Eustace JA. Hyponatremia independent of osteoporosis is associated with fracture occurrence. Clin J Am Soc Nephrol 5:275–80

  • Sandhu HS, Gilles E, DeVita MV, Panagopoulos G, Michelis MF. Hyponatremia associated with large-bone fracture in elderly patients. Int Urol Nephrol 2009;41:733–7

    Article  PubMed  Google Scholar 

  • Lenz K, Gossinger H, Laggner A, Druml W, Grimm G, Schneeweiss B. Influence of hypernatremic-hyperosmolar state on hemodynamics of patients with normal and depressed myocardial function. Crit Care Med 1986;14:913–4

    PubMed  CAS  Google Scholar 

  • Kozeny GA, Murdock DK, Euler DE, et al. In vivo effects of acute changes in osmolality and sodium concentration on myocardial contractility. Am Heart J 1985;109:290–6

    Article  PubMed  CAS  Google Scholar 

  • Bratusch-Marrain PR, DeFronzo RA. Impairment of insulin-mediated glucose metabolism by hyperosmolality in man. Diabetes 1983;32:1028–34

    Article  PubMed  CAS  Google Scholar 

  • Komjati M, Kastner G, Waldhausl W, Bratusch-Marrain P. Detrimental effect of hyperosmolality on insulin-stimulated glucose metabolism in adipose and muscle tissue in vitro. Biochem Med Metab Biol 1988;39:312–8

    Article  PubMed  CAS  Google Scholar 

  • Komjati M, Kastner G, Waldhausl W, Bratusch-Marrain P. Effect of hyperosmolality on basal and hormone-stimulated hepatic glucose metabolism in vitro. Eur J Clin Invest 1989;19:128–34

    Article  PubMed  CAS  Google Scholar 

  • Adrogue HJ, Madias NE. Hypernatremia. N Engl J Med 2000;342:1493–9

    Article  PubMed  CAS  Google Scholar 

  • Lindner G, Funk GC, Lassnigg A, et al. Intensive care-acquired hypernatremia after major cardiothoracic surgery is associated with increased mortality. Intensive Care Med 2010;36:1718–23

    Article  PubMed  Google Scholar 

  • Lindner G, Funk GC, Schwarz C, et al. Hypernatremia in the critically ill is an independent risk factor for mortality. Am J Kidney Dis 2007;50:952–7

    Article  PubMed  Google Scholar 

  • Stelfox HT, Ahmed SB, Khandwala F, Zygun D, Shahpori R, Laupland K. The epidemiology of intensive care unit-acquired hyponatraemia and hypernatraemia in medical-surgical intensive care units. Crit Care 2008;12:R162

    Article  PubMed  Google Scholar 

  • Stelfox HT, Ahmed SB, Zygun D, Khandwala F, Laupland K. Characterization of intensive care unit acquired hyponatremia and hypernatremia following cardiac surgery. Can J Anaesth 2010;57:650–8

    Article  PubMed  Google Scholar 

  • Darmon M, Timsit JF, Francais A, et al. Association between hypernatraemia acquired in the ICU and mortality: a cohort study. Nephrol Dial Transplant 2010;25:2510–5

    Article  PubMed  CAS  Google Scholar 

  • Hoorn EJ, Betjes MG, Weigel J, Zietse R. Hypernatraemia in critically ill patients: too little water and too much salt. Nephrol Dial Transplant 2008;23:1562–8

    Article  PubMed  Google Scholar 

  • Lee CT, Guo HR, Chen JB. Hyponatremia in the emergency department. Am J Emerg Med 2000;18:264–8

    Article  PubMed  CAS  Google Scholar 

  • Adrogue HJ, Madias NE. Hyponatremia. N Engl J Med 2000;342:1581–9

    Article  PubMed  CAS  Google Scholar 

  • Ellison DH, Berl T. Clinical practice. The syndrome of inappropriate antidiuresis. N Engl J Med 2007;356:2064–72

    Article  PubMed  CAS  Google Scholar 

  • Hawkins RC. Age and gender as risk factors for hyponatremia and hypernatremia. Clin Chim Acta 2003;337:169–72

    Article  PubMed  CAS  Google Scholar 

  • Himmelstein DU, Jones AA, Woolhandler S. Hypernatremic dehydration in nursing home patients: an indicator of neglect. J Am Geriatr Soc 1983;31:466–71

    PubMed  CAS  Google Scholar 

  • Clayton JA, Le Jeune IR, Hall IP. Severe hyponatraemia in medical in-patients: aetiology, assessment and outcome. QJM 2006;99:505–11

    Article  PubMed  CAS  Google Scholar 

  • Clayton JA, Rodgers S, Blakey J, Avery A, Hall IP. Thiazide diuretic prescription and electrolyte abnormalities in primary care. Br J Clin Pharmacol 2006;61:87–95

    Article  PubMed  CAS  Google Scholar 

  • Mann SJ. The silent epidemic of thiazide-induced hyponatremia. J Clin Hypertens (Greenwich) 2008;10:477–84

    Article  CAS  Google Scholar 

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Correspondence to Aristomenis Exadaktylos.

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Arampatzis, S., Exadaktylos, A., Buhl, D. et al. Dysnatraemias in the emergency room: Undetected, untreated, unknown?. Wien Klin Wochenschr 124, 181–183 (2012). https://doi.org/10.1007/s00508-011-0108-7

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  • DOI: https://doi.org/10.1007/s00508-011-0108-7

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