Skip to main content

Advertisement

Log in

Update on the creation and maintenance of arteriovenous fistulas for haemodialysis in children

  • Educational Review
  • Published:
Pediatric Nephrology Aims and scope Submit manuscript

Abstract

Arteriovenous fistulas (AVFs) are widely used for haemodialysis (HD) in adults with stage 5 chronic kidney disease (CKD 5) and are generally considered the best form of vascular access (VA). The ‘Fistula First’ initiative in 2003 helped to change the culture of VA in adults. However, this cultural change has not yet been adopted in children despite the fact that a functioning AVF is associated with lower complication rates and longer access survival than a central venous line (CVL). For children with CKD 5, especially when kidney failure starts early in life, there is a risk that all VA options will be exhausted. Therefore, it is essential to develop long-term strategies for optimal VA creation and maintenance. Whilst AVFs are the preferred VA in the paediatric population on chronic HD, they may not be suitable for every child. Recent guidelines and observational data in the paediatric CKD 5 population recommend switching from a ‘Catheter First’ to ‘Catheter Last’ approach. In this review, recent evidence is summarized in order to promote change in current practices.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Borzych-Duzalka D, Shroff R, Ariceta G, Yap YC, Paglialonga F, Xu H, Kang HG, Thumfart J, Aysun KB, Stefanidis CJ, Fila M, Sever L, Vondrak K, Szabo AJ, Szczepanska M, Ranchin B, Holtta T, Zaloszyc A, Bilge I, Warady BA, Schaefer F, Schmitt CP (2019) Vascular access choice, complications, and outcomes in children on maintenance hemodialysis: findings from the International Pediatric Hemodialysis Network (IPHN) Registry. Am J Kidney Dis 74:193–202. https://doi.org/10.1053/j.ajkd.2019.02.014

    Article  PubMed  Google Scholar 

  2. Shroff R, Calder F, Bakkaloğlu S, Nagler EV, Stuart S, Stronach L, Schmitt CP, Heckert KH, Bourquelot P, Wagner AM, Paglialonga F, Mitra S, Stefanidis CJ, European Society for Paediatric Nephrology Dialysis Working Group (2019) Vascular access in children requiring maintenance haemodialysis: a consensus document by the European Society for Paediatric Nephrology Dialysis Working Group. Nephrol Dial Transplant 34:1746–1765. https://doi.org/10.1093/ndt/gfz011

    Article  PubMed  Google Scholar 

  3. Boehm M, Bonthuis M, Noordzij M, Harambat J, Groothoff JW, Melgar ÁA, Buturovic J, Dusunsel R, Fila M, Jander A, Koster-Kamphuis L, Novljan G, Ortega PJ, Paglialonga F, Saravo MT, Stefanidis CJ, Aufricht C, Jager KJ, Schaefer F (2019) Hemodialysis vascular access and subsequent transplantation: a report from the ESPN/ERA-EDTA Registry. Pediatr Nephrol 34:713–721. https://doi.org/10.1007/s00467-018-4129-6

    Article  PubMed  Google Scholar 

  4. https://www.usrds.org/2019/download/USRDS_2019_ES_final.pdf, Accessed 09 June 2020

  5. Basile C, Lomonte C (2007) The operating surgeon is the major determinant for a successful arteriovenous fistula maturation. Kidney Int 72:772. https://doi.org/10.1038/sj.ki.5002206

    Article  CAS  PubMed  Google Scholar 

  6. Prischl FC, Kirchgatterer A, Brandstätter E, Wallner M, Baldinger C, Roithinger FX, Kramar R (1995) Parameters of prognostic relevance to the patency of vascular access in hemodialysis patients. J Am Soc Nephrol 6:1613–1618

    Article  CAS  Google Scholar 

  7. Baracco R, Mattoo T, Jain A, Kapur G, Valentini RP (2014) Reducing central venous catheters in chronic hemodialysis--a commitment to arteriovenous fistula creation in children. Pediatr Nephrol 29:2013–2020. https://doi.org/10.1007/s00467-013-2744-9

    Article  PubMed  Google Scholar 

  8. Souza RA, Oliveira EA, Silva JM, Lima EM (2011) Hemodialysis vascular access in children and adolescents: a ten-year retrospective cohort study. J Bras Nefrol 33:422–430

    Article  Google Scholar 

  9. Davidson I, Gallieni M, Saxena R, Dolmatch B (2007) A patient centered decision making dialysis access algorithm. J Vasc Access 8:59–68

    Article  CAS  Google Scholar 

  10. Chand DH, Bednarz D, Eagleton M, Krajewski L (2009) A vascular access team can increase AV fistula creation in pediatric ESRD patients: a single center experience. Semin Dial 22:679–683. https://doi.org/10.1111/j.1525-139X.2009.00638.x

    Article  PubMed  Google Scholar 

  11. Shroff R, Sterenborg RB, Kuchta A, Arnold A, Thomas N, Stronach L, Padayachee S, Calder F (2016) A dedicated vascular access clinic for children on haemodialysis: two years’ experience. Pediatr Nephrol 31:2337–2344. https://doi.org/10.1007/s00467-016-3428-z

    Article  PubMed  PubMed Central  Google Scholar 

  12. Hayes WN, Watson AR, Callaghan N, Wright E, Stefanidis CJ, European Pediatric Dialysis Working Group (2012) Vascular access: choice and complications in European paediatric haemodialysis units. Pediatr Nephrol 27:999–1004. https://doi.org/10.1007/s00467-011-2079-3

    Article  PubMed  Google Scholar 

  13. Mak RH, Warady BA (2013) Dialysis: vascular access in children--arteriovenous fistula or CVC? Nat Rev Nephrol 9:9–11. https://doi.org/10.1038/nrneph.2012.265

    Article  PubMed  Google Scholar 

  14. Fadrowski JJ, Hwang W, Neu AM, Fivush BA, Furth SL (2009) Patterns of use of vascular catheters for hemodialysis in children in the United States. Am J Kidney Dis 53:91–98. https://doi.org/10.1053/j.ajkd.2008.08.011

    Article  PubMed  Google Scholar 

  15. Erickson KF, Mell M, Winkelmayer WC, Chertow GM, Bhattacharya J (2015) Provider visits and early vascular access placement in maintenance hemodialysis. J Am Soc Nephrol 26:1990–1997. https://doi.org/10.1681/ASN.2014050464

    Article  PubMed  Google Scholar 

  16. Smart NA, Dieberg G, Ladhani M, Titus T (2014) Early referral to specialist nephrology services for preventing the progression to end-stage kidney disease. Cochrane Database Syst Rev 6:CD007333. https://doi.org/10.1002/14651858.CD007333.pub2

    Article  Google Scholar 

  17. Boehm M, Riesenhuber A, Winkelmayer WC, Arbeiter K, Mueller T, Aufricht C (2007) Early erythropoietin therapy is associated with improved growth in children with chronic kidney disease. Pediatr Nephrol 22:1189–1193. https://doi.org/10.1007/s00467-007-0472-8

    Article  PubMed  Google Scholar 

  18. Boehm M, Winkelmayer WC, Arbeiter K, Mueller T, Aufricht C (2010) Late referral to paediatric renal failure service impairs access to pre-emptive kidney transplantation in children. Arch Dis Child 95:634–638. https://doi.org/10.1136/adc.2009.174581

    Article  CAS  PubMed  Google Scholar 

  19. Ma A, Shroff R, Hothi D, Lopez MM, Veligratli F, Calder F, Rees L (2013) A comparison of arteriovenous fistulas and central venous lines for long-term chronic haemodialysis. Pediatr Nephrol 28:321–326. https://doi.org/10.1007/s00467-012-2318-2

    Article  PubMed  Google Scholar 

  20. Manook M, Calder F (2013) Practical aspects of arteriovenous fistula formation in the pediatric population. Pediatr Nephrol 28:885–893. https://doi.org/10.1007/s00467-012-2328-0

    Article  PubMed  Google Scholar 

  21. Malovrh M (1998) Non-invasive evaluation of vessels by duplex sonography prior to construction of arteriovenous fistulas for haemodialysis. Nephrol Dial Transplant 13:125–129. https://doi.org/10.1093/ndt/13.1.125

    Article  CAS  PubMed  Google Scholar 

  22. Hyland K, Cohen RM, Kwak A, Shlansky-Goldberg RD, Soulen MC, Patel AA, Mondschein JI, Solomon JA, Stavropoulos SW, Itkin M, Yeh H, Markmann J, Trerotola SO (2008) Preoperative mapping venography in patients who require hemodialysis access: imaging findings and contribution to management. J Vasc Interv Radiol 19:1027–1033. https://doi.org/10.1016/j.jvir.2008.03.015

    Article  PubMed  Google Scholar 

  23. Menegazzo D, Laissy JP, Dürrbach A, Debray MP, Messin B, Delmas V, Mignon F, Schouman-Claeys E (1998) Hemodialysis access fistula creation: preoperative assessment with MR venography and comparison with conventional venography. Radiology 209:723–728. https://doi.org/10.1148/radiology.209.3.9844665

    Article  CAS  PubMed  Google Scholar 

  24. Fraum TJ, Ludwig DR, Bashir MR, Fowler KJ (2017) Gadolinium-based contrast agents: a comprehensive risk assessment. J Magn Reson Imaging 46:338–353. https://doi.org/10.1002/jmri.25625

    Article  PubMed  Google Scholar 

  25. Matoussevitch V, Taylan C, Konner K, Gawenda M, Kuhr K, Hoppe B, Brunkwall J (2015) AV fistula creation in paediatric patients: outcome is independent of demographics and fistula type reducing usage of venous catheters. J Vasc Access 16:382–387. https://doi.org/10.5301/jva.5000395

    Article  PubMed  Google Scholar 

  26. Bourquelot P, Cussenot O, Corbi P, Pillion G, Gagnadoux MF, Bensman A, Loirat C, Broyer M (1990) Microsurgical creation and follow-up of arteriovenous fistulae for chronic haemodialysis in children. Pediatr Nephrol 4:156–159. https://doi.org/10.1007/BF00858828

    Article  CAS  PubMed  Google Scholar 

  27. Preka E, Bonthuis M, Harambat J, Jager KJ, Groothoff JW, Baiko S, Bayazit AK, Boehm M, Cvetkovic M, Edvardsson VO, Fomina S, Heaf JG, Holtta T, Kis E, Kolvek G, Koster-Kamphuis L, Molchanova EA, Muňoz M, Neto G, Novljan G, Printza N, Sahpazova E, Sartz L, Sinha MD, Vidal E, Vondrak K, Vrillon I, Weber LT, Weitz M, Zagozdzon I, Stefanidis CJ, Bakkaloglu SA (2019) Association between timing of dialysis initiation and clinical outcomes in the paediatric population: an ESPN/ERA-EDTA registry study. Nephrol Dial Transplant 34:1932–1940. https://doi.org/10.1093/ndt/gfz069

    Article  PubMed  Google Scholar 

  28. Karava V, Jehanno P, Kwon T, Deschênes G, Macher MA, Bourquelot P (2018) Autologous arteriovenous fistulas for hemodialysis using microsurgery techniques in children weighing less than 20 kg. Pediatr Nephrol 33:855–862. https://doi.org/10.1007/s00467-017-3854-6

    Article  PubMed  Google Scholar 

  29. Rooijens PP, Tordoir JH, Stijnen T, Burgmans JP, de Smet AA, Yo TI (2004) Radiocephalic wrist arteriovenous fistula for hemodialysis: meta-analysis indicates a high primary failure rate. Eur J Vasc Endovasc Surg 28:583–589. https://doi.org/10.1016/j.ejvs.2004.08.014

    Article  CAS  PubMed  Google Scholar 

  30. Valentini RP, Chand DH (2019) Catheter craze continues for pediatric hemodialysis vascular access: the need to move from catheter first to catheter last. Am J Kidney Dis 74:155–157. https://doi.org/10.1053/j.ajkd.2019.04.013

    Article  PubMed  Google Scholar 

  31. Almási-Sperling V, Galiano M, Lang W, Rother U, Rascher W, Regus S (2016) Timing of first arteriovenous fistula cannulation in children on hemodialysis. Pediatr Nephrol 31:1647–1657. https://doi.org/10.1007/s00467-016-3382-9

    Article  PubMed  Google Scholar 

  32. Onder AM, Flynn JT, Billings AA, Deng F, DeFreitas M, Katsoufis C, Grinsell MM, Patterson LT, Jetton J, Fathallah-Shaykh S, Ranch D, Aviles D, Copelovitch L, Ellis E, Chanda V, Elmaghrabi A, Lin JJ, Butani L, Haddad M, Couloures OM, Brakeman P, Quigley R, Stella Shin H, Garro R, Liu H, Rahimikollu J, Raina R, Langman CB, Wood EG, Midwest Pediatric Nephrology Consortium (2019) Predictors of patency for arteriovenous fistulae and grafts in pediatric hemodialysis patients [published correction appears in Pediatr Nephrol. 2019 Jan 25]. Pediatr Nephrol 34:329–339. https://doi.org/10.1007/s00467-018-4082-4

    Article  PubMed  Google Scholar 

  33. Lok CE, Allon M, Moist L, Oliver MJ, Shah H, Zimmerman D (2006) Risk equation determining unsuccessful cannulation events and failure to maturation in arteriovenous fistulas (REDUCE FTM I). J Am Soc Nephrol 17:3204–3212. https://doi.org/10.1681/ASN.2006030190

    Article  PubMed  Google Scholar 

  34. Vachharajani TJ, Wong L, Niyyar VD, Abreo KD, Mokrzycki MH (2020) Buttonhole cannulation of arteriovenous fistulas in the United States. Kidney360 1:306–313. https://doi.org/10.34067/kid.0000052020

    Article  Google Scholar 

  35. Kamata T, Tomita M, Iehara N (2016) Ultrasound-guided cannulation of hemodialysis access. Renal Replace Ther 2:7. https://doi.org/10.1186/s41100-016-0019-1

    Article  Google Scholar 

  36. Wong B, Muneer M, Wiebe N, Storie D, Shurraw S, Pannu N, Klarenbach S, Grudzinski A, Nesrallah G, Pauly RP (2014) Buttonhole versus rope-ladder cannulation of arteriovenous fistulas for hemodialysis: a systematic review. Am J Kidney Dis 64:918–936. https://doi.org/10.1053/j.ajkd.2014.06.018

    Article  PubMed  Google Scholar 

  37. Smyth W, Hartig V, Manickam V (2013) Outcomes of buttonhole and rope-ladder cannulation techniques in a tropical renal service. J Ren Care 39:157–165. https://doi.org/10.1111/j.1755-6686.2013.12020.x

    Article  PubMed  Google Scholar 

  38. van Loon MM, Goovaerts T, Kessels AG, van der Sande FM, Tordoir JH (2010) Buttonhole needling of haemodialysis arteriovenous fistulae results in less complications and interventions compared to the rope-ladder technique. Nephrol Dial Transplant 25:225–230. https://doi.org/10.1093/ndt/gfp420

    Article  PubMed  Google Scholar 

  39. Haricharan RN, Aprahamian CJ, Morgan TL, Harmon CM, Barnhart DC (2008) Intermediate-term patency of upper arm arteriovenous fistulae for hemodialysis access in children. J Pediatr Surg 43:147–151. https://doi.org/10.1016/j.jpedsurg.2007.09.036

    Article  PubMed  Google Scholar 

  40. Gogalniceanu P, Stuart S, Karunanithy N, Kessaris N, Roebuck D, Calder F (2019) Endovascular intervention in the maintenance and rescue of paediatric arteriovenous fistulae for hemodialysis. Pediatr Nephrol 34:723–727. https://doi.org/10.1007/s00467-018-4143-8

    Article  PubMed  Google Scholar 

  41. Ravani P, Quinn RR, Oliver MJ, Karsanji DJ, James MT, MacRae JM, Palmer SC, Strippoli GF (2016) Preemptive correction of Arteriovenous access stenosis: a systematic review and meta-analysis of randomized controlled trials [published correction appears in Am J Kidney Dis (2017) 70:735]. Am J Kidney Dis 67:446–460

    Article  Google Scholar 

  42. Shetty A, Whittier WL (2012) Does regular surveillance improve the long-term survival of arteriovenous fistulas? Int J Nephrol 2012:539608. https://doi.org/10.1155/2012/539608

    Article  PubMed  Google Scholar 

  43. Jackson VE, Hurst H, Mitra S (2018) Structured physical assessment of arteriovenous fistulae in haemodialysis access surveillance: a missed opportunity? J Vasc Access 19:221–229. https://doi.org/10.1177/1129729817751867

    Article  PubMed  Google Scholar 

  44. Manns B, Tonelli M, Yilmaz S, Lee H, Laupland K, Klarenbach S, Radkevich V, Murphy B (2005) Establishment and maintenance of vascular access in incident hemodialysis patients: a prospective cost analysis. J Am Soc Nephrol 16:201–209. https://doi.org/10.1681/ASN.2004050355

    Article  PubMed  Google Scholar 

  45. Besarab A (2006) Access monitoring is worthwhile and valuable. Blood Purif 24:77–89. https://doi.org/10.1159/000089442

    Article  PubMed  Google Scholar 

  46. Tordoir J, Canaud B, Haage P, Konner K, Basci A, Fouque D, Kooman J, Martin-Malo A, Pedrini L, Pizzarelli F, Tattersall J, Vennegoor M, Wanner C, ter Wee P, Vanholder R (2007) EBPG on vascular access. Nephrol Dial Transplant 22(Suppl 2):ii88–ii117. https://doi.org/10.1093/ndt/gfm021

    Article  PubMed  Google Scholar 

  47. Sidawy AN, Spergel LM, Besarab A, Allon M, Jennings WC, Padberg FT Jr, Murad MH, Montori VM, O’Hare AM, Calligaro KD, Macsata RA, Lumsden AB, Ascher E, Society for Vascular Surgery (2008) The Society for Vascular Surgery: clinical practice guidelines for the surgical placement and maintenance of arteriovenous hemodialysis access. J Vasc Surg 48(5 Suppl):2S–25S. https://doi.org/10.1016/j.jvs.2008.08.042

    Article  PubMed  Google Scholar 

  48. (2006) Clinical practice recommendation 8: Vascular access in pediatric patients. Am J Kidney Dis 48(Suppl 1):S274–S276. https://doi.org/10.1053/j.ajkd.2006.04.049

  49. Aragoncillo I, Abad S, Caldés S, Amézquita Y, Vega A, Cirugeda A, Moratilla C, Ibeas J, Roca-Tey R, Fernández C, Macías N, Quiroga B, Blanco A, Villaverde M, Ruiz C, Martín B, Ruiz AM, Ampuero J, de Alvaro F, López-Gómez JM (2017) Adding access blood flow surveillance reduces thrombosis and improves arteriovenous fistula patency: a randomized controlled trial. J Vasc Access 18:352–358. https://doi.org/10.5301/jva.5000700

    Article  PubMed  Google Scholar 

  50. Ashoor IF, Hughson EA, Somers MJ (2015) Arteriovenous access monitoring with ultrasound dilution in a pediatric hemodialysis unit. Blood Purif 39:93–98. https://doi.org/10.1159/000368976

    Article  PubMed  Google Scholar 

  51. Karava V, Kwon T, Franco G, Georges D, Macher MA, Hogan J (2019) Ultrasound dilution and thermodilution versus color Doppler ultrasound for arteriovenous fistula assessment in children on hemodialysis. Pediatr Nephrol 34:2381–2387. https://doi.org/10.1007/s00467-019-04297-5

    Article  PubMed  Google Scholar 

  52. Unger P, Wissing KM (2006) Arteriovenous fistula after renal transplantation: utility, futility or threat? Nephrol Dial Transplant 21:254–257. https://doi.org/10.1093/ndt/gfi276

    Article  PubMed  Google Scholar 

  53. Besarab A (2008) Resolved: fistulas are preferred to grafts as initial vascular access for dialysis. Pro J Am Soc Nephrol 19:1629–1631. https://doi.org/10.1681/ASN.2008020172

    Article  PubMed  Google Scholar 

  54. Covic A, Gusbeth-Tatomir P, Goldsmith DJ (2003) The challenge of cardiovascular risk factors in end-stage renal disease. J Nephrol 16:476–486

    PubMed  Google Scholar 

  55. Huijbregts HJ, Bots ML, Wittens CH, Schrama YC, Moll FL, Blankestijn PJ, CIMINO study group (2008) Hemodialysis arteriovenous fistula patency revisited: results of a prospective, multicenter initiative. Clin J Am Soc Nephrol 3:714–719. https://doi.org/10.2215/CJN.02950707

    Article  PubMed  PubMed Central  Google Scholar 

  56. Feldman HI, Kobrin S, Wasserstein A (1996) Hemodialysis vascular access morbidity. J Am Soc Nephrol 7:523–535

    Article  CAS  Google Scholar 

  57. Fadel FI, Elshamaa MF, Nabhan MM, Essam RG, Kantoush N, El Sonbaty MM, Raafat M, Abd-El Haleem DA (2014) Soluble adhesion molecules as markers of native arteriovenous fistula thrombosis in children on uremia. Blood Coagul Fibrinolysis 25:675–682. https://doi.org/10.1097/MBC.0000000000000125

    Article  CAS  PubMed  Google Scholar 

  58. Fadel FI, Elshamaa MF, Abdel-Rahman SM, Thabet EH, Kamel S, Kandil D, Ibrahim MH, El-Ahmady M (2016) Coagulation, thrombophilia and patency of arteriovenous fistula in children undergoing haemodialysis compared with healthy volunteers: a prospective analysis. Blood Coagul Fibrinolysis 27:190–198. https://doi.org/10.1097/MBC.0000000000000417

    Article  CAS  PubMed  Google Scholar 

  59. Tanner NC, da Silva AF (2016) Medical adjuvant treatment to improve the patency of arteriovenous fistulae and grafts: a systematic review and meta-analysis. Eur J Vasc Endovasc Surg 52:243–252. https://doi.org/10.1016/j.ejvs.2016.04.016

    Article  CAS  PubMed  Google Scholar 

  60. Sharathkumar A, Hirschl R, Pipe S, Crandell C, Adams B, Lin JJ (2007) Primary thromboprophylaxis with heparins for arteriovenous fistula failure in pediatric patients. J Vasc Access 8:235–244

    Article  CAS  Google Scholar 

  61. US Renal Data System (2006) Annual data report: Atlas of end-stage renal disease in the United States, National Institute of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 2006

  62. Basile C, Lomonte C (2018) The complex relationship among arteriovenous access, heart, and circulation. Semin Dial 31:15–20. https://doi.org/10.1111/sdi.12652

    Article  PubMed  Google Scholar 

  63. Guzzetta PC, Salcedo JR, Bell SB, Ruley EJ (1987) Limb growth and cardiac complications of fistulas in children. Int J Pediatr Nephrol 8:167–170

    CAS  PubMed  Google Scholar 

  64. Lazarides MK, Staramos DN, Kopadis G, Maltezos C, Tzilalis VD, Georgiadis GS (2003) Onset of arterial ‘steal’ following proximal angioaccess: immediate and delayed types. Nephrol Dial Transplant 18:2387–2390. https://doi.org/10.1093/ndt/gfg346

    Article  PubMed  Google Scholar 

  65. Malik J, Tuka V, Kasalova Z, Chytilova E, Slavikova M, Clagett P, Davidson I, Dolmatch B, Nichols D, Gallieni M (2008) Understanding the dialysis access steal syndrome. a review of the etiologies, diagnosis, prevention and treatment strategies. J Vasc Access 9:155–166

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Evgenia Preka.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Answers

1. b; 2. e; 3. e; 4. d; 5. d

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Preka, E., Shroff, R., Stronach, L. et al. Update on the creation and maintenance of arteriovenous fistulas for haemodialysis in children. Pediatr Nephrol 36, 1739–1749 (2021). https://doi.org/10.1007/s00467-020-04746-6

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00467-020-04746-6

Keywords

Navigation