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Incidence, risk factors, and outcomes of acute kidney injury in neonates after surgical procedures

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Abstract

Background

Acute kidney injury (AKI) is common and associated with poor outcomes in critically ill neonates. The objective of this study was to study the incidence, risk factors, and clinical outcomes of AKI in neonates receiving non-cardiac surgery.

Methods

We performed a single-center retrospective study between January 2017 and December 2018 of neonates who had received abdominal and thoracic surgical procedures. AKI was defined by the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Patient information, clinical data, and outcomes were collected and analyzed. Logistic regression was used to analyze risk factors of AKI and association between AKI and mortality.

Results

Fifty-four (33.8%) of 160 patients developed AKI after surgical procedures. Compared with neonates without AKI, neonates with AKI had higher mortality rate (18.5% VS 5.7%, p = 0.022), lower gestational age (30.5 weeks, interquartile range [IQR] 28–33.5, VS 34.5 weeks, IQR 33–37.5, p = 0.035), higher rates of very low birth weight (33.3% VS 17.0%, p = 0.019), longer duration of mechanical ventilation (0.5 days, IQR 0–1.5, VS 0 days, IQR 0–1, p = 0.043) and higher rates of sepsis (35.2% VS 19.8%, p = 0.034). Risk factors of AKI included gestational age under 32 weeks (OR 4.8, 95% CI 1.8–12.6; p = 0.001), sepsis (OR 4.3, 95% CI 1.7–11.3; p = 0.003), operation time longer than 120 min (OR 2.7, 95% CI 1.1–6.6; p = 0.024), and diagnosis of necrotizing enterocolitis (OR 3.5, 95% CI 1.3–9.1; p = 0.011). AKI after surgery was significantly associated with mortality (OR 4.3, 95% CI 1.1–16.9; p = 0.036).

Conclusions

AKI is common and associated with poor outcomes in surgical neonates. Early recognition and intervention of AKI in these patients are important.

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Authors and Affiliations

  1. Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, China

    Yang Wu, Gang Yang, Bo Xiang & Xiaoping Jiang

  2. Department of Neonatology, West China Second Hospital, Sichuan University, Chengdu, China

    Xintian Hua

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  1. Yang Wu
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  2. Xintian Hua
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  3. Gang Yang
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  5. Xiaoping Jiang
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Correspondence to Xiaoping Jiang.

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The ethics committee of West China Hospital of Sichuan University approved the study and informed parental consent was obtained.

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The authors declare that they have no conflict of interest.

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Wu, Y., Hua, X., Yang, G. et al. Incidence, risk factors, and outcomes of acute kidney injury in neonates after surgical procedures. Pediatr Nephrol 35, 1341–1346 (2020). https://doi.org/10.1007/s00467-020-04532-4

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  • DOI: https://doi.org/10.1007/s00467-020-04532-4

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