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Lineage-specific roles of hedgehog-GLI signaling during mammalian kidney development

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Abstract

Aberrant hedgehog (Hh) signaling during embryogenesis results in various severe congenital abnormalities, including renal malformations. The molecular mechanisms that underlie congenital renal malformations remain poorly understood. Here, we review the current understanding of the lineage-specific roles of Hh signaling during renal morphogenesis and how aberrant Hh signaling during embryonic kidney development contributes to renal malformation.

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Author notes

  1. Robert D’Cruz and Katryna Stronks contributed equally to this work.

Authors and Affiliations

  1. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, M5S 1A8, Canada

    Robert D’Cruz, Katryna Stronks & Norman D. Rosenblum

  2. Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 686 Bay Street, Toronto, M5G 0A4, Canada

    Robert D’Cruz, Katryna Stronks, Christopher J. Rowan & Norman D. Rosenblum

  3. Department of Physiology, University of Toronto, Toronto, M5S 1A8, Canada

    Norman D. Rosenblum

  4. Department of Paediatrics, University of Toronto, Toronto, M5S 1A8, Canada

    Norman D. Rosenblum

  5. Division of Nephrology, The Hospital for Sick Children, 555 University Avenue, Toronto, M5G 1X8, Canada

    Norman D. Rosenblum

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  1. Robert D’Cruz
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  2. Katryna Stronks
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Correspondence to Norman D. Rosenblum.

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D’Cruz, R., Stronks, K., Rowan, C.J. et al. Lineage-specific roles of hedgehog-GLI signaling during mammalian kidney development. Pediatr Nephrol 35, 725–731 (2020). https://doi.org/10.1007/s00467-019-04240-8

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  • DOI: https://doi.org/10.1007/s00467-019-04240-8

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