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Prognosis for children with acute kidney injury in the intensive care unit

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Abstract

To define factors of prognostic importance for critically ill infants and children with acute kidney injury (AKI), we have studied 110 children, ages from 1 month to 180 months, admitted between March 1, 2002 and September 30, 2004 to the intensive care unit of Joana de Gusmão Children’s Hospital. These patients represent 8% of all intensive care unit admissions during the entire study period. The diagnosis at admission was primary renal parenchyma disease (eight patients, 7.2%) and secondary renal disease (102 patients, 92.8%). Thirty-seven patients (33.6%) died, all of whom had secondary renal insufficiency; six patients (5.4%) died as a result of septic shock, and 31 (28.2%) patients died from multiple organ failure (MOF). The variables were analyzed using Fisher’s exact test for qualitative variables and Student’s t-test for quantitative variables. Stratified analysis was performed to assess the relative importance of variables using the Mantel–Haenszel technique. Among the variables analyzed, the following were found to be significantly related to mortality: anuria, oliguria, arterial hypotension, need for pressor drugs, need for mechanical ventilation, need for dialysis, the association with MOF, and high values of lactic acid.

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Authors and Affiliations

  1. PICU, Hospital Infantil Joana de Gusmão, Florianópolis, Santa Catarina, Brazil

    Nilzete Bresolin, Vera Fernandes, Jose Góes & Francisca Ligia Carvalho

  2. Centro de Ciências da Saúde, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil

    Carlos Silva

  3. Secretaria Estadual de Saúde, Florianópolis, Santa Catarina, Brazil

    Ana Halllal

  4. Pediatria, Santa Casa de São Paulo, São Paulo, Brazil

    Julio Toporovski

  5. Rua Rui Barbosa, 152, Florianópolis, Santa Catarina, Brazil, 88025-301

    Nilzete Bresolin

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  1. Nilzete Bresolin
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  2. Carlos Silva
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  3. Ana Halllal
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Correspondence to Nilzete Bresolin.

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Bresolin, N., Silva, C., Halllal, A. et al. Prognosis for children with acute kidney injury in the intensive care unit. Pediatr Nephrol 24, 537–544 (2009). https://doi.org/10.1007/s00467-008-1054-0

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  • DOI: https://doi.org/10.1007/s00467-008-1054-0

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