Abstract
Background
Carbon dioxide, the primary gas used to establish a pneumoperitoneum, causes numerous systemic effects related to cardiovascular function and acid-base balance. Therefore, the use of other gases, such as helium, has been proposed. Furthermore, the pneumoperitoneum itself, with the concomitant elevation of intraabdominal pressure, causes local and systemic effects that have been only partly elucidated. Portal blood flow, which plays an important role in hepatic function and cell-conveyed immune response, is one of the affected parameters.
Methods
An established animal model (rat) of laparoscopic surgery was extended by implanting a periportal flow probe. Hemodynamics in the portal vein were then measured by transit-time ultrasonic flowmetry during increasing intraabdominal pressure (2–12 mmHg) caused by gas insufflation (carbon dioxide vs helium).
Results
The installation of the pneumoperitoneum with increasing intraperitoneal pressure led to a significant linear decrease in portal venous flow for both carbon dioxide and helium. At higher pressure levels (8–12 mmHg), portal blood flow was significantly lower (1.5–2.5-fold) during carbon dioxide pneumoperitoneum. An intraabdominal pressure of 8 mmHg caused a decrease to 38.2% of the initial flow (helium, 59.7%); whereas at 12 mmHg, portal flow was decreased to 16% (helium, 40.5%).
Conclusion
Elevated intraabdominal pressure generated by the pneumoperitoneum results in a reduction of portal venous flow. This effect is significantly stronger during carbon dioxide insufflation. Portal flow reduction may compromise hepatic function and cell-conveyed immune response during laparoscopic surgery.
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References
Anderson RJ, Cronin RE, McDonald KM, Schrier RW (1976) Mechanisms of portal hypertension-induced alteration in renal hemodynamics, renal water excretion, and renin secretion. J Clin Invest 58: 964–970
Andersen MN, Kuchiba K (1970) Measurement of acute changes in liver function and blood flow. Arch Surg 100: 541–545
Barnes RJ, Comline RS, Dobson A, Drost CJ (1983) An implantable transit time ultrasonic blood flowmeter. J Physiol 345: 2–3
Berguer R, Gutt CN, Stiegman GV (1993) Laparoscopic surgery in the rat: description of a new technique. Surg Endosc 7: 345–347
Bouvy ND, Marquet RL, Jeekel H, Bonjer HJ (1996) Impact of gas(less) laparoscopy and laparotomy on peritoneal tumor growth and abdominal wall metastases. Ann Surg 6: 694–701
Caldwell CB, Ricotta JJ (1987) Changes in visceral blood flow with elevated intraabdominal pressure. J Surg Res 43: 14–20
Cardoso JE, Giroux L, Kassissia I, Houssin D, Habib N, Huet PM (1994) Liver function improvement following increased portal blood flow in cirrhotic rats. Gastroenterology 107: 460–467
Coleman DL (1986) Regulation of macrophage phagocytosis. Eur J Clin Microbiol 5: 1–5
Cullen DJ, Coyle JP, Teplick R, Long MC (1989) Cardiovascular, pulmonary, and renal effects of massively increased intra-abdominal pressure in critically ill patients. Crit Care Med 17: 118–121
Declan-Fleming RY, Dougherty TB, Feig BW (1997) The safety of helium for abdominal insufflation. Surg Endosc 11: 230–234
Diebel LN, Wilson RF, Dulchavsky SA, Saxe J (1992) Effect of increased intraabdominal pressure on hepatic arterial, portal venous and hepatic microcirculatory blood flow. J Trauma 33: 279–282
Epstein RM, Wheeler HO, Frumin J, Habif DV, Papper EM, Bradley SE (1961) The effect of hypercapnia on estimated hepatic blood flow, circulating splanchnic blood volume, and hepatic sulfobromopthalein clearance during general anesthesia in man. J Clin Invest 40: 592–598
Goeting NL, Fleming JS, Gallagher P, Walmsely BH, Karran SJ (1986) Alterations in liver blood flow and reticuloendothelial function in progressive cirrhosis in the rat. J Nucl Med 27: 1751–1754
Gutt CN, Heinz P, Kaps W, Paolucci V (1997) The phagocytosis activity during conventional and laparoscopic operations in the rat: a preliminary study. Surg Endosc 11:899–901 DOI: 10.1007/s004649900482
Gutt CN, Held S, Heller K, Paolucci V (1996) A small animal model for laparoscopic microsurgery training. Min Invas Ther Allied Technol 5: 302–306
Gutt CN, Schmandra TC (1999) Portal venous flow during CO2 pneumoperitoneum in the rat. Surg Endosc 13: 902–905 DOI: 10.1007/s004649901130
Ho HS, Gunther RA, Wolfe BM (1992) Intraperitoneal carbon dioxide insufflation and cardiopulmonary responses to laparoscopic cholecystectomy in pigs. Arch Surg 127: 928–932
Ho HS, Saunders CJ, Corso FA, Wolfe BM (1993) The effects of CO2 pneumoperitoneum on hemodynamics in hemorrhaged animals. Surg 114: 381–387
Ho HS, Saunders CJ, Gunther RA, Wolfe BM (1995) Effector of hemodynamics during laparoscopy: CO2-absorption or intraabdominal pressure? J Surg Res 59: 497–503
Ishizaki Y, Bandai Y, Shimomura K, Abe H, Ohtomo Y, Idezuki Y (1993) Changes in splanchnic blood flow and cardiovascular effects following peritoneal insufflation of carbon dioxide. Surg Endosc 7: 420–423
Ivankovich AD, Miletich DJ, Albrecht MD, Heymann HJ, Bonnet RF (1975) Cardiovascular effects of intraperitoneal insufflation with carbon dioxide and nitrous oxide in the dog. Anesthesiology 42: 281–287
Jakimowicz J, Stultiens G, Smulders F (1998) Laparoscopic insufflation of the abdomen reduces portal venous flow. Surg Endosc 12: 129–132 DOI: 10.1007/s004649900612
Johnson PC (1964) Review of previous studies and current theories of autoregulation. In: Johnson PC (ed) Autoregulation of blood flow. American Heart Association, New York, pp 1–9
Kashtan J, Green JF, Parson EQ, Holcroft JW (1989) Hemodynamic effects of increased abdominal pressure. J Surg Res 30: 249–255
Kotzampassi K, Kapanidis N, Kazamias P, Elefteriadis E (1993) Hemodynamic events in the peritoneal environment during pneumoperitoneum in dogs. Surg Endosc 7: 494–499
Leighton T, Liu S, Bongard FS (1993) Comparative cardiopulmonary effects of carbon dioxide versus helium pneumoperitoneum. Surgery 113: 527–531
Leighton T, Pianim N, Liu S, Kono M, Klein S, Bongard F (1992) Effectors of hypercarbia during experimental pneumoperitoneum. Am J Surg 58: 717–721
Nashat KH, Slater DN, Underwood JC, Triger DR, Woods HF (1985) Phagocytic function in the isolated perfused rat liver: an experimental model. J Hepatol 1: 153–166
Normann SJ (1972) Reticuloendothelial system function. V. Studies on the correlation between phagocytic rate and liver blood flow. J Reticuloendothel Soc 12: 473–484
Normann SJ (1973) Reticuloendothelial system function. VI. Experimental alterations influencing the correlation between portal blood flow and colloid clearance. J Reticuloendothel Soc 13: 47–60
Price HL (1960) Effects of carbon dioxide on the cardiovascular system. Anesthesiology 21: 652–655
Punnonen R, Viinamaki O (1982) Vasopressin release during laparoscopy: role of increased intraabdominal pressure. Lancet 8264: 175–176
Reichen J, Egger B, Ohara N, Zeltner TB, Zysset T, Zimmermann A (1988) Determinants of hepatic function in liver cirrhosis in the rat: multivariate analysis. J Clin Invest 82: 2069–2076
Richardson JD, Trinkle JK (1976) Hemodynamic and respiratory alterations with increased intraabdominal pressure. J Surg Res 20: 401–404
Shimizu M, Hiroshi Y, Hatori N, Hag Y, Okuda E, Uriuda Y, Tanaka S (1990) Acute effect of intraabdominal presure on liver and systemic circulation. Vasc Surg 24: 677–682
Van den Bos GC, Drake AJ, Noble MI (1979) The effect of carbon dioxide upon myocardial contractile performance, blood flow and oxygen consumption. J Physiol 287: 149–161
Welch WJ, Deng X, Snellen H, Wilcox CS (1995) Validation of miniature ultrasonic transit-time flow probes for measurement of renal blood flow in rats. Am J Physiol 268: 175–178
Westerband A, Van de Water JM, Amzallag M (1992) Cardiovascular changes during laparoscopic cholecystectomy. Surg Gynecol Obstet 175: 535–538
Williams MD, Murr PC (1993) Laparoscopic insufflation of the abdomen depresses cardiopulmonary function. Surg Endosc 7: 12–16
Wittgen CM, Andrus CH, Fitzgerald SD, Baudendistel LJ, Dahms TE, Kaminski DL (1991) Analysis of the hemodynamic and ventilatory effects of laparoscopic cholecystectomy. Arch Surg 126: 997–1000
Wunsch A (1997) Influence of different gases used for insufflation on the pH of subcutaneous tissue. First Workshop on experimental laparoscopic surgery, Frankfurt, 7–8 March, 1997, section: Metabolism and immunology in laparoscopy, Surg Endosc 12: 1096–1098
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Online publication: 12 December 2000
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Schmandra, T.C., Kim, Z.G. & Gutt, C.N. Effect of insufflation gas and intraabdominal pressure on portal venous flow during pneumoperitoneum in the rat. Surg Endosc 15, 405–408 (2001). https://doi.org/10.1007/s004640000331
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DOI: https://doi.org/10.1007/s004640000331