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Surgical management of gastroesophageal reflux disease in the obese patient

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Abstract

Background

Gastroesophageal reflux disease (GERD) affects two thirds of the American population. Obesity is also a disease that affects two thirds of the population. The pathophysiology of reflux disease is reasonably understood, however, the degree to which obesity affects this disease remains poorly defined. Therefore the approach to GERD in the obese patient requires special attention and its own algorithm.

Methods

A literature search was conducted to consolidate the current available literature on GERD and its management in the obese. In addition, the authors reviewed the literature and present expert opinion on controversial topics.

Results

It is well established that GERD is increased in obesity and the pathophysiology is reviewed. Management options for GERD are discussed, with a focus on the obese population. Management strategies including fundoplication and gastric bypass are discussed. In addition, bariatric surgery in the setting of GERD is also reviewed.

Conclusions

Currently this is an extremely controversial topic and this white paper presents a strong review of the literature to help guide the management of this challenging disease in this population. Expert recommendations are given throughout the paper based upon the current available data.

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References

  1. Camilleri M, Dubois D, Coulie B et al (2005) Prevalence and socioeconomic impact of upper gastrointestinal disorders in the United States: results of the US upper gastrointestinal study. Clin Gastroenterol Hepatol 3(6):543–552

    PubMed  Google Scholar 

  2. El-Serag HB (2007) Time trends of gastroesophageal reflux disease: a systematic review. Clin Gastroenterol Hepatol 5(1):17–26

    PubMed  Google Scholar 

  3. Kulig M, Leodolter A, Vieth M et al (2003) Quality of life in relation to symptoms in patients with gastro-oesophageal reflux disease: an analysis based on the ProGERD initiative. Aliment Pharmacol Ther 18(8):767–776

    CAS  PubMed  Google Scholar 

  4. Hales C, Carroll, Fryar C, Ogden C (2015) Prevalence of obesity among adults and youth: United States, 2015–2016. NCHS Data Brief, No. 288, October 2017

  5. Cawley J, Meyerhoefer C (2012) The medical care costs of obesity: an instrumental variables approach. J Health Econ 31(1):219–230

    PubMed  Google Scholar 

  6. Finkelstein EA, Trogdon JG, Cohen JW, Dietz W (2009) Annual medical spending attributable to obesity: payer-and service-specific estimates: amid calls for health reform, real cost savings are more likely to be achieved through reducing obesity and related risk factors. Health Aff 28(Suppl1):w822–w831

    Google Scholar 

  7. El-Serag H (2008) The association between obesity and GERD: a review of the epidemiological evidence. Dig Dis Sci 53(9):2307–2312. https://doi.org/10.1007/s10620-008-0413-9

    Article  PubMed  PubMed Central  Google Scholar 

  8. El-Serag HB, Graham DY, Satia JA, Rabeneck L (2005) Obesity is an independent risk factor for GERD symptoms and erosive esophagitis. Am J Gastroenterol 100:1243. https://doi.org/10.1111/j.1572-0241.2005.41703.x

    Article  PubMed  Google Scholar 

  9. Herbella FA, Sweet MP, Tedesco P, Nipomnick I, Patti MG (2007) Gastroesophageal reflux disease and obesity. Pathophysiology and implications for treatment. J Gastrointest Surg 11(3):286–290. https://doi.org/10.1007/s11605-007-0097-z

    Article  PubMed  Google Scholar 

  10. Jacobson BC, Somers SC, Fuchs CS, Kelly CP, Camargo CA Jr (2006) Body-mass index and symptoms of gastroesophageal reflux in women. N Engl J Med 354(22):2340–2348

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Hampel H, Abraham NS, El-Serag HB (2005) Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann Intern Med 143(3):199–211

    PubMed  Google Scholar 

  12. Crowell MD, Bradley A, Hansel S, Dionisio P, Kim HJ, Decker GA, Sharma VK (2009) Obesity is associated with increased 48-h esophageal acid exposure in patients with symptomatic gastroesophageal reflux. Am J Gastroenterol 104(3):553–559. https://doi.org/10.1038/ajg.2009.5

    Article  PubMed  Google Scholar 

  13. Anand G, Katz PO (2008) Gastroesophageal reflux disease and obesity. Rev Gastroenterol Disord 8(4):233–239

    PubMed  Google Scholar 

  14. Jung HS, Choi MG, Baeg MK, Lim CH, Kim JS, Cho YK et al (2013) Obesity is associated with increasing esophageal acid exposure in korean patients with gastroesophageal reflux disease symptoms. J Neurogastroenterol Motil 19(3):338–343. https://doi.org/10.5056/jnm.2013.19.3.338

    Article  PubMed  PubMed Central  Google Scholar 

  15. Kouklakis G, Moschos J, Kountouras J, Mpoumponaris A, Molyvas E, Minopoulos G (2005) Relationship between obesity and gastroesophageal reflux disease as recorded by 3-hour esophageal pH monitoring. Rom J Gastroenterol 14(2):117–121

    PubMed  Google Scholar 

  16. Hoyo C, Cook MB, Kamangar F, Freedman ND, Whiteman DC, Bernstein L et al (2012) Body mass index in relation to oesophageal and oesophagogastric junction adenocarcinomas: a pooled analysis from the International BEACON Consortium. Int J Epidemiol 41(6):1706–1718. https://doi.org/10.1093/ije/dys176

    Article  PubMed  PubMed Central  Google Scholar 

  17. Wu JC, Mui LM, Cheung CM, Chan Y, Sung JJ (2007) Obesity is associated with increased transient lower esophageal sphincter relaxation. Gastroenterology 132(3):883–889. https://doi.org/10.1053/j.gastro.2006.12.032

    Article  PubMed  Google Scholar 

  18. Stene-Larsen G, Weberg R, Froyshov Larsen I, Bjortuft O, Hoel B, Berstad A (1988) Relationship of overweight to hiatus hernia and reflux oesophagitis. Scand J Gastroenterol 23(4):427–432

    CAS  PubMed  Google Scholar 

  19. Wilson LJ, Ma W, Hirschowitz BI (1999) Association of obesity with hiatal hernia and esophagitis. Am J Gastroenterol 94(10):2840–2844

    CAS  PubMed  Google Scholar 

  20. Stefanidis D, Hope WW, Kohn GP et al (2010) Guidelines for surgical treatment of gastroesophageal reflux disease. Surg Endosc 24(11):2647–2669

    PubMed  Google Scholar 

  21. Katz PO, Gerson LB, Vela MF (2013) Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 108(3):308–328 (Quiz 329)

    PubMed  Google Scholar 

  22. Schietroma M, Piccione F, Clementi M, Cecilia EM, Sista F, Pessia B, Carlei F, Guadagni S, Amicucci G (2017) Short- and long-term, 11–22 years, results after laparoscopic nissen fundoplication in obese versus nonobese patients. J Obes 2017:7589408

    PubMed  PubMed Central  Google Scholar 

  23. Frezza EE, Ikramuddin S, Gourash W et al (2002) Symptomatic improvement in gastroesophageal reflux disease (GERD) following laparoscopic Roux-en-Y gastric bypass. Surg Endosc 16(7):1027–1031

    CAS  PubMed  Google Scholar 

  24. Nelson LGGR, Haines K, Gallagher SF, Murr MM (2005) Amelioration of gastroesophageal reflux symptoms following Roux-en-Y gastric bypass for clinically significant obesity. Am Surg 71:950–953

    PubMed  Google Scholar 

  25. Madalosso CAS, Gurski RR, Callegari-Jacques SM, Navarini D, Mazzini G, Pereira MDS (2016) The impact of gastric bypass on gastroesophageal reflux disease in morbidly obese patients. Ann Surg 263(1):110–116

    PubMed  Google Scholar 

  26. Mejía-Rivas MAH, Hernández-Calleros J, Herrera MF, Valdovinos MA (2008) Gastroesophageal reflux disease in morbid obesity: the effect of Roux-en-Y gastric bypass. Obes Surg 18:1217–1224

    PubMed  Google Scholar 

  27. Farmer AD, Ruffle JK, Aziz Q (2017) The role of esophageal hypersensitivity in functional esophageal disorders. J Clin Gastroenterol 51(2):91–99

    PubMed  Google Scholar 

  28. Anderson SH, Yadegarfar G, Arastu MH, Anggiansah R, Anggiansah A (2006) The relationship between gastro-oesophageal reflux symptoms and achalasia. Eur J Gastroenterol Hepatol 18(4):369–374

    PubMed  Google Scholar 

  29. Patterson EJ, Davis DG, Khajanchee Y, Swanström LL (2003) Comparison of objective outcomes following laparoscopic Nissen fundoplication versus laparoscopic gastric bypass in the morbidly obese with heartburn. Surg Endosc 17(10):1561–1565

    CAS  PubMed  Google Scholar 

  30. Perez ARMA, Rattner DW (2001) Obesity adversely affects the outcome of antireflux operations. Surg Endosc 15:986–989

    CAS  PubMed  Google Scholar 

  31. LE Morgenthal CB, Shane MD, Hunter JG, Smith CD (2007) Who will fail laparoscopic Nissen fundoplication? Preoperative prediction of long-term outcomes. Surg Endosc 21:1978–1984

    PubMed  Google Scholar 

  32. Prachand VN, Alverdy JC (2010) Gastroesophageal reflux disease and severe obesity: fundoplication or bariatric surgery? World J Gastroenterol 16:3757–3761

    PubMed  PubMed Central  Google Scholar 

  33. Kavanagh R, Smith J, Bashir U, Jones D, Avgenakis E, Nau P (2019) Optimizing bariatric surgery outcomes: a novel preoperative protocol in a bariatric population with gastroesophageal reflux disease. Surg Endosc. https://doi.org/10.1007/s00464-019-06934-4

    Article  PubMed  Google Scholar 

  34. Spechler SJ, Lee E, Ahnen D, Goyal RK, Hirano I, Ramirez F, Raufman JP, Sampliner R, Schnell T, Sontag S, Vlahcevic ZR, Young R, Williford W (2001) Long-term outcome of medical and surgical therapies for gastroesophageal reflux disease: follow-up of a randomized controlled trial. JAMA 285(18):2331–2338

    CAS  PubMed  Google Scholar 

  35. Varela JE, Hinojosa MW, Nguyen NT (2009) Laparoscopic fundoplication compared with laparoscopic gastric bypass in morbidly obese patients with gastroesophageal reflux disease. Surg Obes Relat Dis 5(2):139–143

    PubMed  Google Scholar 

  36. Raftopoulos IAO, Courcoulas AP, Luketich JD (2004) Laparoscopic gastric bypass after antireflux surgery for the treatment of gastroesophageal reflux in morbidly obese patients: initial experience. Obes Surg 14:1373–1380

    PubMed  Google Scholar 

  37. Ibele AGM, Gould J (2012) The impact of previous fundoplication on laparoscopic gastric bypass outcomes: a case-control evaluation. Surg Endosc 26:177–181

    PubMed  Google Scholar 

  38. Kellogg TA, Andrade R, Maddaus M, Slusarek B, Buchwald H, Ikramuddin S (2007) Anatomic findings and outcomes after antireflux procedures in morbidly obese patients undergoing laparoscopic conversion to Roux-en-Y gastric bypass. Surg Obes Relat Dis 3(1):52–57 (Discussion 58–59)

    PubMed  Google Scholar 

  39. Nadaleto BFHF, Patti MG (2016) Gastroesophageal reflux disease in the obese: pathophysiology and treatment. Surgery 159:475–486

    PubMed  Google Scholar 

  40. LE Braghetto I, Korn O, Valladares H, Molina JC, Henriquez A (2010) Manometric changes of the lower esophageal sphincter after sleeve gastrectomy in obese patients. Obes Surg 20:357–362

    PubMed  Google Scholar 

  41. Daes JJM, Said N, Daza JC, Dennis R (2012) Laparoscopic sleeve gastrectomy: symptoms of gastroesophageal reflux can be reduced by changes in surgical technique. Obes Surg 22:1874–1879

    PubMed  PubMed Central  Google Scholar 

  42. Keidar AAL, Schweiger C, Elazary R, Baltasar A (2010) Dilated upper sleeve can be associated with severe postoperative gastroesophageal dysmotility and reflux. Obes Surg 20:140–147

    PubMed  Google Scholar 

  43. LA Melissas J, Klinaki I, Perisinakis K, Koukouraki S, de Bree E, Karkavitsas N (2013) Alterations of global gastrointestinal motility after sleeve gastrectomy: a prospective study. Ann Surg 258:976–982

    PubMed  Google Scholar 

  44. Alhaj Saleh A, Janik MR, Mustafa RR, Alshehri M, Khan AH, Kalantar Motamedi SM, Rahim S, Patel I, Aryaie A, Abbas M, Rogula T, Khaitan L (2018) Does sleeve shape make a difference in outcomes? Obes Surg 28(6):1731–1737

    PubMed  Google Scholar 

  45. Del Genio GTS, Limongelli P, Brusciano L, D’Alessandro A, Docimo G, Rossetti G, Silecchia G, Iannelli A, del Genio A, del Genio F, Docimo L (2014) Sleeve gastrectomy and development of “de novo” gastroesophageal reflux. Obes Surg 24:71–77

    PubMed  Google Scholar 

  46. Burgerhart JSSC, Schoon EJ, Smulders JF, van de Meeberg PC, Siersema PD, Smout AJ (2014) Effect of sleeve gastrectomy on gastroesophageal reflux. Obes Surg 24:1436–1441

    PubMed  Google Scholar 

  47. Felsenreich DMKR, Schermann M, Beckerhinn P, Kristo I, Krebs M, Prager G, Langer FB (2017) Reflux, sleeve dilation, and Barrett’s esophagus after laparoscopic sleeve gastrectomy: long-term follow-up. Obes Surg 27:3092–3101

    PubMed  Google Scholar 

  48. Genco ASE, Casella G, Maselli R, Castagneto-Gissey L, Di Lorenzo N, Basso N (2017) Gastroesophageal reflux disease and Barrett’s esophagus after laparoscopic sleeve gastrectomy: a possible, underestimated long-term complication. Surg Obes Relat Dis 13:568–574

    PubMed  Google Scholar 

  49. DuPree CEBK, Steele SR, Martin MJ (2014) Laparoscopic sleeve gastrectomy in patients with preexisting gastroesophageal reflux disease: a national analysis. JAMA Surg 149:328–334

    PubMed  Google Scholar 

  50. Sheppard CESD, de Gara CJ, Karmali S, Birch DW (2015) Rates of reflux before and after laparoscopic sleeve gastrectomy for severe obesity. Obes Surg 25:763–768

    PubMed  Google Scholar 

  51. Pagé MP, Kastenmeier A, Goldblatt M, Frelich M, Bosler M, Wallace J, Gould J (2014) Medically refractory gastroesophageal reflux disease in the obese: what is the best surgical approach? Surg Endosc 28(5):1500–1504

    PubMed  Google Scholar 

  52. Nadaleto BF, Herbella FA, Patti MG (2016) Gastroesophageal reflux disease in the obese: pathophysiology and treatment. Surgery 159(2):475–486

    PubMed  Google Scholar 

  53. Peterli R, Wölnerhanssen BK, Peters T, Vetter D, Kröll D, Borbély Y, Schultes B, Beglinger C, Drewe J, Schiesser M, Nett P, Bueter M (2018) Effect of laparoscopic sleeve gastrectomy vs laparoscopic roux-en-y gastric bypass on weight loss in patients with morbid obesity: the SM-BOSS randomized clinical trial. JAMA 319(3):255–265. https://doi.org/10.1001/jama.2017.20897

    Article  PubMed  PubMed Central  Google Scholar 

  54. Oelschlager BK, Pellegrini CA, Hunter JG et al (2011) Biologic prosthesis to prevent recurrence after laparoscopic paraesophageal hernia repair: long-term follow-up from a multicenter, prospective, randomized trial. J Am Coll Surg 213(4):461–468

    PubMed  Google Scholar 

  55. Mahawar KK, Carr WR, Jennings N, Balupuri S, Small PK (2015) Simultaneous sleeve gastrectomy and hiatus hernia repair: a systematic review. Obes Surg 25(1):159–166

    PubMed  Google Scholar 

  56. Olmi S, Caruso F, Uccelli M, Cioffi S, Ciccarese F, Cesana G (2017) Laparoscopic sleeve gastrectomy combined with Rossetti fundoplication (R-Sleeve) for treatment of morbid obesity and gastroesophageal reflux. Surg Obes Relat Dis 13(12):1945–1950

    PubMed  Google Scholar 

  57. Hawasli A, Reyes M, Hare B, Meguid A, Harriott A, Almahmeed T, Thatimatla N, Szpunar S (2016) Can morbidly obese patients with reflux be offered laparoscopic sleeve gastrectomy? A case report of 40 patients. Am J Surg 211(3):571–576

    PubMed  Google Scholar 

  58. Lasnibat JP, Braghetto I, Gutierrez L, Sanchez F (2017) Sleeve gastrectomy and fundoplication as a single procedure in patients with obesity and gastroesophageal reflux. Arq Bras Cir Dig 30(3):216–221

    PubMed  PubMed Central  Google Scholar 

  59. Rebecchi F, Allaix ME, Patti MG, Schlottmann F, Morino M (2017) Gastroesophageal reflux disease and morbid obesity: to sleeve or not to sleeve? World J Gastroenterol 23(13):2269–2275

    PubMed  PubMed Central  Google Scholar 

  60. Rebecchi F, Allaix ME, Giaccone C, Ugliono E, Scozzari G, Morino M (2014) Gastroesophageal reflux disease and laparoscopic sleeve gastrectomy: a physiopathologic evaluation. Ann Surg 260(5):909–915

    PubMed  Google Scholar 

  61. Stenard F, Iannelli A (2015) Laparoscopic sleeve gastrectomy and gastroesophageal reflux. World J Gastroenterol 21(36):10348–10357

    PubMed  PubMed Central  Google Scholar 

  62. Oor JE, Roks DJ, Ünlü Ç, Hazebroek EJ (2016) Laparoscopic sleeve gastrectomy and gastroesophageal reflux disease: a systematic review and meta-analysis. Am J Surg 211(1):250–267

    PubMed  Google Scholar 

  63. Ayazi S, Hagen JA, Chan LS, DeMeester SR, Lin MW, Ayazi A, Crookes PF (2009) Obesity and gastroesophageal reflux: quantifying the association between body mass index, esophageal acid exposure, and lower esophageal sphincter status in a large series of patients with reflux symptoms. J Gastrointest Surg 13(8):1440–1447

    PubMed  PubMed Central  Google Scholar 

  64. Goitein D, Sakran N, Rayman S, Szold A, Goitein O, Raziel A (2017) Barium swallow for hiatal hernia detection is unnecessary prior to primary sleeve gastrectomy. Surg Obes Relat Dis 13(2):138–142

    PubMed  Google Scholar 

  65. Ghassemian AJ, MacDonald KG, Cunningham PG, Swanson M, Brown BM, Morris PG et al (1997) The workup for bariatric surgery does not require a routine upper gastrointestinal series. Obes Surg 7(1):16–18

    CAS  PubMed  Google Scholar 

  66. Schirmer B, Erenoglu C, Miller A (2002) Flexible endoscopy in the management of patients undergoing Roux-en-Y gastric bypass. Obes Surg 12(5):634–638

    PubMed  Google Scholar 

  67. Saarinen T, Kettunen U, Pietiläinen KH, Juuti A (2018) Is preoperative gastroscopy necessary before sleeve gastrectomy and Roux-en-Y gastric bypass? Surg Obes Relat Dis 14(6):757–762

    PubMed  Google Scholar 

  68. Telem DA, Gould J, Pesta C et al (2017) American society for metabolic and bariatric surgery: care pathway for laparoscopic sleeve gastrectomy. Surg Obes Relat Dis 13(5):742–749

    PubMed  Google Scholar 

  69. Küper MA, Kratt T, Kramer KM, Zdichavsky M, Schneider JH, Glatzle J, Stüker D, Königsrainer A, Brücher BL (2010) Effort, safety, and findings of routine preoperative endoscopic evaluation of morbidly obese patients undergoing bariatric surgery. Surg Endosc 24(8):1996–2001

    PubMed  Google Scholar 

  70. Bradley DD, Louie BE, Chen J, Aye RW, McMahon R, Farivar AS (2015) The effect of concurrent esophageal pathology on bariatric surgical planning. J Gastrointest Surg 19(1):111–115 (Discussion 115–116)

    PubMed  Google Scholar 

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Correspondence to L. Khaitan.

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P Nau, H. Jackson, A. Aryaie, A. Ibele, D. Shouhed, E. Lo Menzo, M. Kurian, L. Khaitan have no conflicts of interest or financial ties to disclose.

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Nau, P., Jackson, H.T., Aryaie, A. et al. Surgical management of gastroesophageal reflux disease in the obese patient. Surg Endosc 34, 450–457 (2020). https://doi.org/10.1007/s00464-019-07231-w

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