Abstract
Background and objectives
Postoperative pain is one of the significant problems in laparoscopic surgery, especially during the first 6–12 h. This randomized controlled trial aimed to investigate the effect of combined preemptive etoricoxib 120 mg and low-pressure pneumoperitoneum for the management of pain after laparoscopic cholecystectomy (LC).
Patients and methods
One hundred and twenty patients aged 18–75 with American Society of Anesthesiologists class I–II who were candidates for elective LC were recruited into the study. The patients were randomly divided into two groups, by ‘block of four’ randomization. The treatment group received preemptive etoricoxib 120 mg and intraabdominal pressure of 7 mmHg, and the control group received placebo and intraabdominal pressure of 14 mmHg. The postoperative pain score at rest was recorded utilizing a numeric rating scale at 1, 2, 6, 10, 14, 18, 22, and 24 h. Pain on movement/ambulation (cough) was also recorded at 6, 10, 14, 18, 22, and 24 h.
Results
There were no significant differences in the baseline characteristics of the two groups. The pain scores of the treatment versus control group of abdominal pain and incisional pain were significant on movement. Abdominal pain scores of the treatment group were decreased 0.98 when compared with the control group (p = 0.017), and incisional pain scores were also decreased 0.99 (p = 0.001). The incidences of postoperative shoulder/back pain were statistically significant: 41.8 % vs. 66.7 % in the treatment and control group, respectively (p = 0.009). The postoperative hospital stay in the treatment group and control group was: 1 day = 96.4 and 75.0 %, >1 day = 3.6 and 25.0 %, respectively (p = 0.001).
Conclusions
A combination of preemptive etoricoxib and low-pressure pneumoperitoneum had significant effects in decreasing overall pain and the incidence of shoulder/back pain after LC and also shortened the hospital stay.
Clinical trials registration number
TCTR20140213001.
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References
Bisgaard T, Klarskov B, Rosenberg J, Kehlet H (2001) Characteristics and prediction of early pain after laparoscopic cholecystectomy. Pain 90:261–269
Kehlet H, Rung GW, Callesen T (1996) Postoperative opioid analgesia: time for a reconsideration? J Clin Anesth 8:441–445
Apfelbaum JL, Chen C, Mehta SS, Gan TJ (2003) Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg 97:534–540
Sandhu T, Paiboonworachat S, Ko-iam W (2011) Effects of preemptive analgesia in laparoscopic cholecystectomy: a double-blind randomized controlled trial. Surg Endosc 25:23–27
Sandhu T, Yamada S, Ariyakachon V, Chakrabandhu T, Chongruksut W, Ko-iam W (2009) Low-pressure pneumoperitoneum versus standard pneumoperitoneum in laparoscopic cholecystectomy, a prospective randomized clinical trial. Surg Endosc 23:1044–1047
Dahl JB, Rosenberg J, Dirkes WE, Mogensen T, Kehlet H (1990) Prevention of postoperative pain by balanced analgesia. Br J Anaesth 64:518–520
Ure BM, Troidl H, Spangenberger W, Dietrich A, Lefering R, Neugebauer E (1994) Pain after laparoscopic cholecystectomy. Intensity and localization of pain and analysis of predictors in preoperative symptoms and intraoperative events. Surg Endosc 8:90–96
Khaitan L, Apelgren K, Hunter J, Traverso LW (2003) A report on the Society of American Gastrointestinal Endoscopic Surgeons (SAGES) Outcomes Initiative: what have we learned and what is its potential? Surg Endosc 17:365–370
Michaloliakou C, Chung F, Sharma S (1996) Preoperative multimodal analgesia facilitates recovery after ambulatory laparoscopic cholecystectomy. Anesth Analg 82:44–51
Qin X, Huo Y, Langman CB, Hou F, Chen Y, Matossian D, Xu X, Wang X (2011) Folic acid therapy and cardiovascular disease in ESRD or advanced chronic kidney disease: a meta-analysis. Clin J Am Soc Nephrol 6:482–488
Adams JP, Murphy PG (2000) Obesity in anaesthesia and intensive care. Br J Anaesth 85:91–108
Cheng PGB, Lim MJ, Onsiong MK, Chiu KYW, Chan MK, Li KWM, Tang CN (2004) Celecoxib premedication in post-operative analgesia for laparoscopic cholecystectomy. Acute Pain 6:23–28
Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240:205–213
Bisgaard T, Klarskov B, Kristiansen VB, Callesen T, Schulze S, Kehlet H, Rosenberg J (1999) Multi-regional local anesthetic infiltration during laparoscopic cholecystectomy in patients receiving prophylactic multi-modal analgesia: a randomized, double-blinded, placebo-controlled study. Anesth Analg 89:1017–1024
Joris J, Thiry E, Paris P, Weerts J, Lamy M (1995) Pain after laparoscopic cholecystectomy: characteristics and effect of intraperitoneal bupivacaine. Anesth Analg 81:379–384
Wallace DH, Serpell MG, Baxter JN, O’Dwyer PJ (1997) Randomized trial of different insufflation pressures for laparoscopic cholecystectomy. Br J Surg 84:455–458
Joshi GP, Viscusi ER, Gan TJ, Minkowitz H, Cippolle M, Schuller R, Cheung RY, Fort JG (2004) Effective treatment of laparoscopic cholecystectomy pain with intravenous followed by oral COX-2 specific inhibitor. Anesth Analg 98:336–342
Cochrane DJ, Jarvis B, Keating GM (2002) Etoricoxib. Drugs 62:2637–2651 (discussion 2652–2653)
Agrawal NG, Porras AG, Matthews CZ, Woolf EJ, Miller JL, Mukhopadhyay S, Neu DC, Gottesdiener KM (2001) Dose proportionality of oral etoricoxib, a highly selective cyclooxygenase-2 inhibitor, in healthy volunteers. J Clin Pharmacol 41:1106–1110
Dallob A, Hawkey CJ, Greenberg H, Wight N, De Schepper P, Waldman S, Wong P, DeTora L, Gertz B, Agrawal N, Wagner J, Gottesdiener K (2003) Characterization of etoricoxib, a novel, selective COX-2 inhibitor. J Clin Pharmacol 43:573–585
Hunt RH, Harper S, Watson DJ, Yu C, Quan H, Lee M, Evans JK, Oxenius B (2003) The gastrointestinal safety of the COX-2 selective inhibitor etoricoxib assessed by both endoscopy and analysis of upper gastrointestinal events. Am J Gastroenterol 98:1725–1733
Acknowledgments
The present study was supported by Research Fund for Royal College of Surgeons of Thailand. The authors acknowledge the following groups and individuals to the development of this study: Mrs Prapa Chantaramungkorn, the hospital pharmacist who prepared the study drugs throughout the study, anesthesiologists, and staff nurses in the operating room, recovery room, and surgery wards at Chiang Mai University Hospital.
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Wasana Ko-iam, Sahataya Paiboonworachat, Paisal Pongchairerks, Sunhawit Junrungsee, and Trichak Sandhu have no conflicts of interest or financial ties to disclose.
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Ko-iam, W., Paiboonworachat, S., Pongchairerks, P. et al. Combination of etoricoxib and low-pressure pneumoperitoneum versus standard treatment for the management of pain after laparoscopic cholecystectomy: a randomized controlled trial. Surg Endosc 30, 4800–4808 (2016). https://doi.org/10.1007/s00464-016-4810-4
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DOI: https://doi.org/10.1007/s00464-016-4810-4