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Predictive factors associated with postoperative pancreatic fistula after laparoscopic distal pancreatectomy: a 10-year single-institution experience

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Abstract

Background

Laparoscopic distal pancreatectomy (LDP) is a treatment option for benign and borderline pancreatic tumors. However, pancreatic fistula (PF) remains a significant morbidity, contributing to the length of hospital stay and overall costs. In a consecutive series of 143 patients at a single institution, the predictive factors associated with PF after LDP were identified.

Methods

A retrospective study of patients who had undergone LDP between January 2003 and December 2013 was conducted. Patient demographic data and clinicopathological parameters were analyzed to evaluate their correlation with the incidence of PF.

Results

Among the 143 patients, the indications for surgery were benign disease in 117 (82 %) and malignant tumors in 26 (18 %). PF occurred in 25 (17 %) patients, 10 (40 %) of whom had clinically significant (grade B) PF. No grade C PF was observed. Multivariable analysis showed that pancreatic thickness was a significant predictive factor for PF (P < 0.001). A 12-mm cutoff value was based on the median pancreatic thickness in this series. Pancreatic texture alone was not a significant risk factor (P = 0.30); however, it became significant in patients with pancreatic thickness exceeding 12 mm (P = 0.005).

Conclusions

Pancreatic thickness exceeding 12 mm significantly increases the likelihood of PF after LDP. Pancreatic texture alone is not an independent risk factor for PF, but when combined with a thick parenchyma (>12 mm), a soft pancreas is predictive of PF.

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Disclosures

Dr. Mendoza, Han, Ahn, Yoon, Cho and Choi have no conflicts of interest or financial ties to disclose.

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Authors and Affiliations

  1. Department of Surgery, University of Santo Tomas Hospital, Manila, Philippines

    Arturo S. Mendoza III

  2. Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 166 Gumi-ro, Bundang-gu, Seongam-si, Seoul, Gyeonggi-do, 463-707, Korea

    Ho-Seong Han, Yoo-Seok Yoon, Jai Young Cho & YoungRok Choi

  3. Division of Statistics, Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seoul, Korea

    Soyeon Ahn

Authors
  1. Arturo S. Mendoza III
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  2. Ho-Seong Han
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  3. Soyeon Ahn
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  4. Yoo-Seok Yoon
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  5. Jai Young Cho
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  6. YoungRok Choi
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Correspondence to Ho-Seong Han.

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Mendoza, A.S., Han, HS., Ahn, S. et al. Predictive factors associated with postoperative pancreatic fistula after laparoscopic distal pancreatectomy: a 10-year single-institution experience. Surg Endosc 30, 649–656 (2016). https://doi.org/10.1007/s00464-015-4255-1

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  • DOI: https://doi.org/10.1007/s00464-015-4255-1

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