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Laparoscopic Nissen versus Toupet fundoplication: objective and subjective results of a prospective randomized trial

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Abstract

Background

Although symptom outcomes following laparoscopic fundoplication have been adequately evaluated in the past, comparative subjective data of laparoscopic Nissen and Toupet fundoplications are scarce. Multichannel intraluminal impedance monitoring (MII) has not been used so far for comparison of objective data.

Methods

One hundred patients with documented chronic gastroesophageal reflux disease (GERD) were randomly allocated to either floppy Nissen fundoplication (group I, n = 50) or Toupet fundoplication (group II, n = 50). Gastrointestinal Quality of Life Index (GIQLI), symptom grading, esophageal manometry, and MII data were documented preoperatively and 3 months after surgery. Subjective and objective outcome data were compared to those of healthy individuals.

Results

Symptom intensity was significantly more severe and GIQLI showed impairment in the examined patient population compared to healthy controls. Both procedures resulted in a significant improvement in GIQLI and GERD symptoms (p < 0.01). Dysphagia improved significantly only in group II, while cough, asthma, and distortion of taste improved significantly in both groups. Hoarseness symptoms showed some degree of improvement in both groups but reached statistical significance only in group I. Postoperatively, bowel symptoms partly increased and the ability to belch decreased in both groups (p < 0.05). Comparison of postoperative GIQLI and symptom scores showed no significant difference between the two groups, except for the ability to belch, which was more impaired after Nissen fundoplication. Both procedures resulted in a significant improvement in lower esophageal sphincter (LES) pressure; however, the improvement was greater in group I than in group II. MII data showed more reflux control after Nissen, but the differences between the procedures were not significant.

Conclusions

Both procedures equally improve quality of life and GERD symptoms. Bowel symptoms may increase after both procedures at the 3-month follow-up. Manometry and MII data favor Nissen fundoplication, but dysphagia and the inability to belch are more common compared to Toupet fundoplication.

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Disclosure

Oliver Owen Koch, Adolf Kaindlstorfer, Stavros A. Antoniou, Kai Uwe Asche, Frank Alexander Granderath, and Rudolph Pointner have no conflicts of interest or financial ties to disclose.

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Authors and Affiliations

  1. Department of General Surgery, General Hospital Zell am See, Paracelsusstraße 8, 5700, Zell am See, Austria

    Oliver O. Koch, Adolf Kaindlstorfer, Kai Uwe Asche & Rudolph Pointner

  2. Department of General and Visceral Surgery, Neuwerk Hospital, Mönchengladbach, Germany

    Stavros A. Antoniou & Frank A. Granderath

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  1. Oliver O. Koch
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  2. Adolf Kaindlstorfer
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  3. Stavros A. Antoniou
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Correspondence to Oliver O. Koch.

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Koch, O.O., Kaindlstorfer, A., Antoniou, S.A. et al. Laparoscopic Nissen versus Toupet fundoplication: objective and subjective results of a prospective randomized trial. Surg Endosc 26, 413–422 (2012). https://doi.org/10.1007/s00464-011-1889-5

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  • DOI: https://doi.org/10.1007/s00464-011-1889-5

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