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Prognostic significance of endoluminal ultrasound-defined disease length and tumor volume (EDTV) for patients with the diagnosis of esophageal cancer

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Abstract

Background

This study aimed to assess the prognostic significance of endoluminal ultrasound-defined total length of disease and endoluminal ultrasound defined tumor volume (EDTV) in esophageal cancer. The hypothesis was that endoscopic ultrasound (EUS)-defined total length of disease and EDTV are both significant prognostic indicators and better predictors of outcome than endoscopic tumor length.

Methods

In this study, 174 consecutive patients (median age, 64 years and 128 months) underwent specialist EUS, and the maximum potential EDTV was calculated (πr 2 L, where r is the tumor thickness and L is the total length of disease) including proximal and distal lymph node metastases. Of the 174 patients, 104 underwent surgery (70 had neoadjuvant chemotherapy), 60 underwent definitive chemoradiotherapy, and 10 had palliative therapy.

Results

Survival was related to EUS T stage (p = 0.013), EUS N stage (p = 0.001), EUS M1a stage (p = 0.004), EUS disease length (<8 cm; p = 0.001), and EDTV (all patients <25 cm3, p = 0.001; surgical patients <40 cm3, p = 0.036). Forward conditional multivariate analysis showed three factors to be associated with survival: EUS N stage (hazard ratio [HR], 1.646; 95% confidence interval [CI], 1.041–2.602; p = 0.033), EUS M1a stage (HR, 2.702; 95% CI, 1.069–6.830; p = 0.036), and EDTV (HR, 2.702; 95% CI, 1.069–6.830; p = 0.025). Median and 2-year survival for EDTV <25 cm3 versus >25 cm3 was 43.4 months and 56%, respectively, compared with 23.5 months and 35%.

Conclusions

In this study, EDTV based on total EUS-defined length of disease emerged as a new and important prognostic indicator for patients with esophageal cancer.

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Acknowledgments

The authors thank Mr. G. Clark and Mr. T. Havard, consultant general surgeons who treated patients in this study and kindly allowed access to their patients’ details.

Disclosure

Drs. Christopher P. Twine, S. Ashley Roberts, Wyn G. Lewis, B. Vicki Dave, Claire E. Rawlinson, David Chan, Mark Robinson, and Tom D. Crosby have no conflicts of interest or financial ties to disclose.

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Authors and Affiliations

  1. Department of Surgery, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, UK

    Christopher P. Twine, Wyn G. Lewis, B. Vicki Dave, Claire E. Rawlinson & David Chan

  2. Department of Radiology, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, UK

    S. Ashley Roberts

  3. Department of Radiology, Royal Gwent Hospital, Newport, UK

    Mark Robinson

  4. Department of Oncology, Velindre Hospital, Cardiff, UK

    Tom D. Crosby

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  1. Christopher P. Twine
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Correspondence to Wyn G. Lewis.

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Twine, C.P., Ashley Roberts, S., Lewis, W.G. et al. Prognostic significance of endoluminal ultrasound-defined disease length and tumor volume (EDTV) for patients with the diagnosis of esophageal cancer. Surg Endosc 24, 870–878 (2010). https://doi.org/10.1007/s00464-009-0681-2

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  • DOI: https://doi.org/10.1007/s00464-009-0681-2

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