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Enzymatic synthesis of poly-l-lactide-co-glycolide in the ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate

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Abstract

This article reports the lipase-catalyzed ring-opening copolymerization of l-lactide (LLA) and glycolide using the commercially available ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate as solvent media. Candida antarctica lipase B, immobilized in an acrylic support was used as biocatalyst. The reaction temperature had a direct influence on yields and molecular weights of the copolymers as well as LLA incorporation. The materials presented semi-crystalline structures assessed by DSC and powder XR diffraction analyses.

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Acknowledgments

We would like to thank funding from CONACyT and scholarship (MM). We would also like to thank DGAPA-UNAM for postdoctoral grant (SCh) and funding through project #IN-200109-3.

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Authors and Affiliations

  1. Depto. Alimentos y Biotecnología, Facultad de Química, Universidad Nacional Autónoma de Mexico, Ciudad Universitaria, Mexico D.F., 04510, Mexico

    María Mena, Sébastien Chanfreau, Miquel Gimeno & Eduardo Bárzana

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  1. María Mena
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  2. Sébastien Chanfreau
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  3. Miquel Gimeno
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  4. Eduardo Bárzana
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Correspondence to Miquel Gimeno or Eduardo Bárzana.

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Mena, M., Chanfreau, S., Gimeno, M. et al. Enzymatic synthesis of poly-l-lactide-co-glycolide in the ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate. Bioprocess Biosyst Eng 33, 1095–1101 (2010). https://doi.org/10.1007/s00449-010-0435-5

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  • DOI: https://doi.org/10.1007/s00449-010-0435-5

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