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Lateralisation in Parkinson disease

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Abstract

Asymmetry of dopaminergic neurodegeneration and subsequent lateralisation of motor symptoms are distinctive features of Parkinson’s disease compared to other forms of neurodegenerative or symptomatic parkinsonism. Even 200 years after the first description of the disease, the underlying causes for this striking clinicopathological feature are not yet fully understood. There is increasing evidence that lateralisation of disease is due to a complex interplay of hereditary and environmental factors that are reflected not only in the concept of dominant hemispheres and handedness but also in specific susceptibilities of neuronal subpopulations within the substantia nigra. As a consequence, not only the obvious lateralisation of motor symptoms occurs but also patterns of associated non-motor signs are defined, which include cognitive functions, sleep behaviour or olfaction. Better understanding of the mechanisms contributing to lateralisation of neurodegeneration and the resulting patterns of clinical phenotypes based on bilateral post-mortem brain analyses and clinical studies focusing on right/left hemispheric symptom origin will help to develop more targeted therapeutic approaches, taking into account subtypes of PD as a heterogeneous disorder.

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Abbreviations

Aß:

ß-amyloid

aPS:

atypical Parkinsonian Syndrome

α-Syn:

α-synuclein

ß-CIT:

iodine-123-(2-carboxymethoxy-3-(4-iodophenyl)tropane)

DASS:

depression anxiety stress scales

DSB:

definite suicidal behaviour

DA:

dopamine

DAT:

dopamine transporter

18F-DOPA:

fluorine-18-labelled fluorodopa

DTI:

Diffusion Tensor Imaging

FDG:

fluordesoxyglucose

GBA:

glucocerebrosidase

HELP:

Help Advance Luxembourg’s Parkinson Research Study

LB:

Lewy body

LC:

locus coeruleus

LPD:

left-dominant Parkinson’s disease

LBD:

Lewy body dementia

LOPD:

late-onset Parkinson’s disease

LRRK2:

leucine-rich repeat kinase 2

MDS:

International Parkinson and Movement Disorder Society

MRI:

magnetic resonance imaging

MSA:

multiple system atrophy

MSA-P:

multiple system atrophy-type parkinson

MOCA:

Montreal Cognitive Assessment

MPTP:

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

NAA:

N-acetylaspartate

OB:

olfactory bulb

6-OHDA:

6-hydroxydopamine

PD:

Parkinson’s disease

PDD:

Parkinson’s disease with dementia

PSP:

progressive supranuclear palsy

PET:

positron emission tomography

PFF:

preformed fibrils

REM:

rapid eye movement

RPD:

right-dominant Parkinson’s disease

RN:

raphe nucleus

SN:

substantia nigra

SNc:

substantia nigra pars compacta

SPECT:

single-photon-emission computed tomography

TH:

tyrosine hydroxylase

UPDRS:

United Parkinson’s Disease Rating Scale

YOPD:

young-onset Parkinson’s disease

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Acknowledgements

The work of RK, GH and PK was supported by grants from the Luxembourg National Research Fund (FNR) within the National Centre of Excellence in Research on Parkinson’s disease (NCER-PD), the PEARL programme (FNR; FNR/P13/6682797 to RK) and by the European Union’s Horizon2020 research and innovation program under grant agreement No. 692320 (CENTRE-PD to RK).

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  1. Center of Mental Health, Clinic and Policlinic for Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, Margarete-Höppel-Platz 1, 97080, Würzburg, Germany

    P. Riederer

  2. Psychiatry Department of Clinical Research, University of Southern Denmark, Odense University Hospital, J.B. Winsløws Vej 18, Indgang 220 A, DK-5000, Odense C, Denmark

    P. Riederer

  3. Institute of Clinical Neurobiology, Alberichgasse 5/13, A-1150, Vienna, Austria

    K. A. Jellinger

  4. Parkinson Research Clinic, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg

    P. Kolber, G. Hipp & R. Krüger

  5. Department of Medical Physiology, University of Nairobi, PO Box 30197, Nairobi, 00100, Kenya

    J. Sian-Hülsmann

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Riederer, P., Jellinger, K.A., Kolber, P. et al. Lateralisation in Parkinson disease. Cell Tissue Res 373, 297–312 (2018). https://doi.org/10.1007/s00441-018-2832-z

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  • DOI: https://doi.org/10.1007/s00441-018-2832-z

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