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Epigenetics of kidney disease

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Abstract

DNA methylation and histone modifications determine renal programming and the development and progression of renal disease. The identification of the way in which the renal cell epigenome is altered by environmental modifiers driving the onset and progression of renal diseases has extended our understanding of the pathophysiology of kidney disease progression. In this review, we focus on current knowledge concerning the implications of epigenetic modifications during renal disease from early development to chronic kidney disease progression including renal fibrosis, diabetic nephropathy and the translational potential of identifying new biomarkers and treatments for the prevention and therapy of chronic kidney disease and end-stage kidney disease.

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Acknowledgments

The authors gratefully acknowledge the support of their work by a Marie Curie EU grant (CIG 293568; to W.B.W.), the Margarete von Wrangell Habilitationsprogramm, Ministerium für Wissenschaft Baden-Württemberg (to W.B.W.) and the Mathilde-Wagner-Habilitationspreis (to W.B.W.). This study was also supported by the German Research Foundation (DFG) within the CRC 1140 and CRC 992. The authors thank all members of their laboratory for their support and helpful discussions and apologize to those colleagues whose work has not been cited because of length restrictions.

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Authors and Affiliations

  1. Department of Medicine IV, Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Nicola Wanner & Wibke Bechtel-Walz

  2. Center for Systems Biology (ZBSA), Albert-Ludwigs-University, Freiburg, Germany

    Nicola Wanner

  3. Renal Division, University Hospital Freiburg, Breisacher Strasse 66, 79106, Freiburg, Germany

    Nicola Wanner & Wibke Bechtel-Walz

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  1. Nicola Wanner
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Correspondence to Nicola Wanner or Wibke Bechtel-Walz.

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Wanner, N., Bechtel-Walz, W. Epigenetics of kidney disease. Cell Tissue Res 369, 75–92 (2017). https://doi.org/10.1007/s00441-017-2588-x

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