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The “omics” of human male infertility: integrating big data in a systems biology approach

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Abstract

Spermatogenesis is a complex process in which >2300 genes are temporally and spatially regulated to form a terminally differentiated sperm cell that must maintain the ability to contribute to a totipotent embryo which can successfully differentiate into a healthy individual. This process is dependent on fidelity of the genome, epigenome, transcriptome, and proteome of the spermatogonia, supporting cells, and the resulting sperm cell. Infertility and/or disease risk may increase in the offspring if abnormalities are present. This review highlights the recent advances in our understanding of these processes in light of the “omics revolution”. We briefly review each of these areas, as well as highlight areas of future study and needs to advance further.

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Acknowledgments

This work was supported in part by grants from the Spanish Ministry of Economy and Competitiveness (Ministerio de Economia y Competitividad; PI13/00699), from Fundacion Salud 2000 (SERONO 13-015) to RO and National Institutes of Health (5R01HD078641) to KIA and DTC.

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Authors and Affiliations

  1. Department of Surgery (Urology), Salt Lake City, UT, USA

    D. T. Carrell, K. I. Aston & B. R. Emery

  2. Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT, USA

    D. T. Carrell

  3. Human Genetics Research Group, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Faculty of Medicine, University of Barcelona, Barcelona, Spain

    R. Oliva

  4. Department of Obstetrics and Gynecology, University of Minnesota, Minneapolis, MN, USA

    C. J. De Jonge

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Carrell, D.T., Aston, K.I., Oliva, R. et al. The “omics” of human male infertility: integrating big data in a systems biology approach. Cell Tissue Res 363, 295–312 (2016). https://doi.org/10.1007/s00441-015-2320-7

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