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Aberrant protamine 1/protamine 2 ratios in sperm of infertile human males

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Protamines were extracted from the sperm of fertile and infertile human males and the relative proportion of protamines 1, 2, and 3 were determined by scanning microdensitometry following electrophoresis of total protamine in polyacrylamide gels. The proportion of the three protamines was found to be similar in sperm obtained from different normal males. The distribution of protamines in sperm obtained from a select group of infertile males producing an elevated level of large sperm heads, in contrast, was different from that of the fertile males.

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Authors and Affiliations

  1. Biomedical Sciences Division, L-452 Lawrence Livermore National Laboratory, 94550, Livermore, California, USA

    R. Balhorn

  2. Matanzas Creek Winery, 6097 Bennett Valley Road, 95404, Santa Rosa, California, USA

    S. Reed

  3. Departments of Obstetrics and Gynecology and Anatomy and Cellular Biology, Harvard Medical School, Dana Biomedical Research Institute, Beth Israel Hospital, 330 Brookline Avenue, 02215, Boston, Massachusett, USA

    N. Tanphaichitr

Authors
  1. R. Balhorn
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  2. S. Reed
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  3. N. Tanphaichitr
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Balhorn, R., Reed, S. & Tanphaichitr, N. Aberrant protamine 1/protamine 2 ratios in sperm of infertile human males. Experientia 44, 52–55 (1988). https://doi.org/10.1007/BF01960243

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