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Survival of auditory hair cells

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Abstract

The inability of mammals to regenerate auditory hair cells creates a pressing need to understand the means of enhancing hair cell survival following insult or injury. Hair cells are easily damaged by noise exposure, by ototoxic medications and as a consequence of aging processes, all of which lead to progressive and permanent hearing impairment as hair cells are lost. Significant efforts have been invested in designing strategies to prevent this damage from occurring since permanent hearing loss has a profound impact on communication and quality of life for patients. In this mini-review, we discuss recent progress in the use of antioxidants, anti-inflammatories and apoptosis inhibitors to enhance hair cell survival. We conclude by clarifying the distinction between protection and rescue strategies and by highlighting important areas of future research.

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Authors and Affiliations

  1. Huffington Center on Aging and Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA

    Michelle L. Seymour & Fred A. Pereira

  2. The Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, TX 77030, USA

    Fred A. Pereira

Authors
  1. Michelle L. Seymour
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  2. Fred A. Pereira
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Correspondence to Fred A. Pereira.

Additional information

This work was supported by DC009622 (F.A.P.) and by NIDCD/NIH NRSA award number F31DC012503 (M.L.S.).

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Seymour, M.L., Pereira, F.A. Survival of auditory hair cells. Cell Tissue Res 361, 59–63 (2015). https://doi.org/10.1007/s00441-015-2152-5

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  • DOI: https://doi.org/10.1007/s00441-015-2152-5

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