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Discovery and development of N-cadherin antagonists

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Abstract

This article describes over 20 years of research on antagonists of the cell adhesion molecule, N-cadherin. Four types of antagonists are discussed: synthetic linear peptides, synthetic cyclic peptides, non-peptidyl peptidomimetics of the disulfide linked cyclic peptide N-Ac-CHAVC-NH2 and monoclonal antibodies directed against the N-cadherin ectodomain. The biological activities of these antagonists are also discussed. In particular, the ability of N-cadherin antagonists to act as anti-cancer drugs is considered.

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Acknowledgements

I thank Tracey Rowlands for helpful comments concerning the manuscript.

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Authors and Affiliations

  1. Division of Urology, Department of Surgery, McGill University, Montreal, QC, Canada

    Orest W. Blaschuk

  2. Urology Research Laboratories, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, QC, H3A 1A1, Canada

    Orest W. Blaschuk

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  1. Orest W. Blaschuk
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Correspondence to Orest W. Blaschuk.

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Blaschuk, O.W. Discovery and development of N-cadherin antagonists. Cell Tissue Res 348, 309–313 (2012). https://doi.org/10.1007/s00441-011-1320-5

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  • DOI: https://doi.org/10.1007/s00441-011-1320-5

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