Abstract
To identify quantitative trait loci (QTLs) that contribute to obesity, we performed a large-scale whole genome linkage scan (WGS) involving 4,102 individuals from 434 Caucasian families. The most pronounced linkage evidence was found at the genomic region 20p11-12 for fat mass (LOD = 3.31) and percentage fat mass (PFM) (LOD = 2.92). We also identified several regions showing suggestive linkage signals (threshold LOD = 1.9) for obesity phenotypes, including 5q35, 8q13, 10p12, and 17q11.
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References
Almasy L, Blangero J (1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198–1211
Deng HW, Deng H, Liu YJ, Liu YZ, Xu FH, Shen H, Conway T, Li JL, Huang QY, Davies KM, Recker RR (2002) A genomewide linkage scan for quantitative-trait loci for obesity phenotypes. Am J Hum Genet 70:1138–1151
Feitosa MF, Borecki IB, Rich SS, Arnett DK, Sholinsky P, Myers RH, Leppert M, Province MA (2002) Quantitative-trait loci influencing body-mass index reside on chromosomes 7 and 13: the National Heart, Lung, and Blood Institute Family Heart Study. Am J Hum Genet 70:72–82
Gorlova OY, Amos CI, Wang NW, Shete S, Turner ST, Boerwinkle E (2003) Genetic linkage and imprinting effects on body mass index in children and young adults. Eur J Hum Genet 11:425–432
Kopelman PG (2000) Obesity as a medical problem. Nature 404:635–643
Lander E, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241–247
Liu YJ, Araujo S, Recker RR, Deng HW (2003) Molecular and genetic mechanisms of obesity: implications for future management. Curr Mol Med 3:325–340
Livshits G, Yakovenko K, Ginsburg E, Kobyliansky E (1998) Genetics of human body size and shape: pleiotropic and independent genetic determinants of adiposity. Ann Hum Biol 25:221–236
Perusse L, Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ, Argyropoulos G, Walts B, Snyder EE, Bouchard C (2005) The human obesity gene map: the 2004 update. Obes Res 13:381–490
Platte P, Papanicolaou GJ, Johnston J, Klein CM, Doheny KF, Pugh EW, Roy-Gagnon MH, Stunkard AJ, Francomano CA, Wilson AF (2003) A study of linkage and association of body mass index in the Old Order Amish. Am J Med Genet C Semin Med Genet 121:71–80
Rice T, Perusse L, Bouchard C, Rao DC (1999) Familial aggregation of body mass index and subcutaneous fat measures in the longitudinal Quebec family study. Genet Epidemiol 16:316–334
Rocha JL, Eisen EJ, Van Vleck LD, Pomp D (2004) A large-sample QTL study in mice: II. Body composition. Mamm Genome 15:100–113
Acknowledgments
Investigators of this work were partially supported by grants from NIH (K01 AR021170-01, R01 AR45349-01, and R01 GM60402-01A1) and an LB595 grant from the State of Nebraska. The genotyping experiment was performed by Marshfield Center for Medical Genetics and supported by NHLBI Mammalian Genotyping Service (Contract Number HV48141).
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Zhao, LJ., Xiao, P., Liu, YJ. et al. A genome-wide linkage scan for quantitative trait loci underlying obesity related phenotypes in 434 Caucasian families. Hum Genet 121, 145–148 (2007). https://doi.org/10.1007/s00439-006-0286-y
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DOI: https://doi.org/10.1007/s00439-006-0286-y