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A large-sample QTL study in mice: II. Body composition

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Abstract

Using lines of mice having undergone long-term selection for high and low growth, a large-sample (n = ~1,000 F2) experiment was conducted to gain further understanding of the genetic architecture of complex polygenic traits. Composite interval mapping on data from male F2 mice (n = 552) detected 50 QTL on 15 chromosomes impacting weights of various organ and adipose subcomponents of growth, including heart, liver, kidney, spleen, testis, and subcutaneous and epididymal fat depots. Nearly all aggregate growth QTL could be interpreted in terms of the organ and fat subcomponents measured. More than 25% of QTL detected map to MMU2, accentuating the relevance of this chromosome to growth and fatness in the context of this cross. Regions of MMU7, 15, and 17 also emerged as important obesity “hot-spots.” Average degrees of directional dominance are close to additivity, matching expectations for body composition traits. A strong QTL congruency is evident among heart, liver, kidney, and spleen weights. Liver and testis are organs whose genetic architectures are, respectively, most and least aligned with that for aggregate body weight. In this study, growth and body weight are interpreted in terms of organ subcomponents underlying the macro aggregate traits, and anchored on the corresponding genomic locations.

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Acknowledgements

We gratefully acknowledge Mary Ann Cushman, Stephenie Foster, and Grady Beck for collection of genotypic data. J.L. Rocha acknowledges the support of the Portuguese Foundation for Science and Technology. This research is a contribution of the University of Nebraska Agricultural Research Division (Lincoln, neb.; Journal Series No. 14110) and the North Carolina Agricultural Research Service, and was supported in part by funds provided through the Hatch Act. This research was also partially based upon work supported by the National Science Foundation under Grant No. 0091900 (Nebraska EPSCOR infrastructure improvement grant).

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Authors and Affiliations

  1. Department of Animal Science, University of Nebraska, Lincoln, Nebraska 68583-0908, USA

    Joao L. Rocha & Daniel Pomp

  2. Department of Animal Science, North Carolina State University, Raleigh, North Carolina 27695-7621, USA

    Eugene J. Eisen

  3. USDA, ARS, USMARC, Lincoln, Nebraska 68583-0908, USA

    L. Dale Van Vleck

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  1. Joao L. Rocha
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  2. Eugene J. Eisen
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  3. L. Dale Van Vleck
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  4. Daniel Pomp
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Correspondence to Daniel Pomp.

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Rocha, J.L., Eisen, E.J., Dale Van Vleck, L. et al. A large-sample QTL study in mice: II. Body composition . Mamm Genome 15, 100–113 (2004). https://doi.org/10.1007/s00335-003-2308-6

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