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Praziquantel and albendazole in the combined treatment of experimental hydatid disease

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Abstract

The combination of praziquantel and albendazole (PZ + ABZ) used in the present study demonstrated an efficacy of 100% when used as chemoprophylactic treatment because no viable hydatid cysts developed after mice had been injected with protoscolices. However, when the PZ + ABZ combination was used for the treatment of 4-month secondary experimental hydatidosis, no significant difference was found between the control and treated mice, although severe damage to the cyst ultrastructure of the treated mice was observed.

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Authors and Affiliations

  1. Parasitology Laboratory, Faculty of Pharmacy, University of Alcalá, Ctra. Madrid-Barcelona Km. 33,600, 28871 Alcalá de Henares (Madrid), Spain e-mail: nieves.casado@uah.es Tel.: +34-91-8854638; Fax: +34-91-8854663, , , , , , ES

    M. J. Moreno, M. A. Urrea-París, N. Casado & F. Rodriguez-Caabeiro

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  1. M. J. Moreno
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  2. M. A. Urrea-París
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  3. N. Casado
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  4. F. Rodriguez-Caabeiro
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Received: 17 June 2000 / Accepted: 14 September 2000

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Moreno, M., Urrea-París, M., Casado, N. et al. Praziquantel and albendazole in the combined treatment of experimental hydatid disease. Parasitol Res 87, 235–238 (2001). https://doi.org/10.1007/s004360000334

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  • DOI: https://doi.org/10.1007/s004360000334

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