Abstract.
A cDNA encoding transportin, a protein involved in the nuclear import of M9 nuclear localization signal-bearing proteins, has been cloned from the malaria parasite Plasmodium falciparum. The complete cDNA consists of 3,667 bp encoding 1,136 amino acid residues. Amino acid sequence analysis revealed that Ran-GTP and M9 binding domains are highly conserved in P. falciparum, suggesting that the transportin-mediated nuclear transport pathway exists in this protozoan parasite. Southern blot analysis revealed that the transportin gene exists as a single copy in the malarial genome.
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Xu, X., Yamasaki, H., Feng, Z. et al. Molecular cloning and characterization of Plasmodium falciparum transportin. Parasitol Res 88, 391–394 (2002). https://doi.org/10.1007/s00436-001-0578-z
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DOI: https://doi.org/10.1007/s00436-001-0578-z