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Roles of long noncoding RNAs in gastric cancer and their clinical applications

  • Review - Cancer Research
  • Published:
Journal of Cancer Research and Clinical Oncology Aims and scope Submit manuscript

Abstract

Purpose

Gastric cancer ranks as the most common cancer in the world. However, the progresses of its diagnosis and treatment are still not satisfactory. The purpose of this study is to summarize the roles of lncRNAs associated with gastric cancer.

Methods

We searched lncRNAs associated with gastric cancer in PubMed.

Results

Long noncoding RNAs (lncRNAs), transcripts larger than 200 nucleotides, regulate gene expression at various levels. They are playing important roles in the occurrence and development of gastric cancer. They are involved in signaling pathways, crosstalk with microRNAs, and affecting metastasis by regulating epithelial-to-mesenchymal transition. By acting as oncogenes or tumor suppressors, lncRNAs contribute to gastric cancer occurrence and development. Several lncRNAs including HOTAIR, HULC, LINC00152, MALAT2, H19, GHET1, and GACAT3 have been demonstrated having oncogene activities, while other lncRNAs including LEIGC, GAS5, and FER1L4 have been thought as tumor suppressors.

Conclusions

Several lncRNAs from tissue, blood, and gastric juice have shown potential values in gastric cancer diagnosis or prognosis evaluation.

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Funding

This study was funded by the Zhejiang Provincial Natural Science Foundation of China (No. LY14C060003), the Applied Research Project on Nonprofit Technology of Zhejiang Province (No. 2016C33177), the National Natural Science Foundation of China (No. 81171660), and the K. C. Wong Magna Fund in Ningbo University.

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Authors and Affiliations

  1. Ningbo Yinzhou People’s Hospital and the Affiliated Yinzhou Hospital, Ningbo University School of Medicine, 315040, Ningbo, China

    Weiliang Sun

  2. Zhejiang Key Laboratory of Pathophysiology, Department of Biochemistry and Molecular Biology, Ningbo University School of Medicine, 315211, Ningbo, China

    Yunben Yang, Chunjing Xu, Yi Xie & Junming Guo

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  1. Weiliang Sun
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  2. Yunben Yang
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  3. Chunjing Xu
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  4. Yi Xie
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Correspondence to Junming Guo.

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Sun, W., Yang, Y., Xu, C. et al. Roles of long noncoding RNAs in gastric cancer and their clinical applications. J Cancer Res Clin Oncol 142, 2231–2237 (2016). https://doi.org/10.1007/s00432-016-2183-7

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  • DOI: https://doi.org/10.1007/s00432-016-2183-7

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