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ERCC2 Lys751Gln and Asp312Asn polymorphisms and gastric cancer risk: a meta-analysis

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Abstract

Purpose

Studies investigating the association between excision repair cross-complimentary group 2 (ERCC2) polymorphisms and gastric cancer (GC) risk have reported conflicting results. We performed a meta-analysis of published epidemiological studies to derive a more precise estimation of the relationship.

Methods

Published literature from PubMed, EMBASE, and China National Knowledge Infrastructure was retrieved. Ten studies with 2,141 GC cases and 5,343 controls were selected.

Results

No association between ERCC2 Lys751Gln polymorphism and GC susceptibility for all genetic models was found. When stratified by race, we found the Gln/Gln genotype carriers might be at high risk of GC among Asians, but not among Caucasians. Also, the pooled results showed there was a significant difference in genotype distribution between non-gastric cardia cancer cases and controls. For ERCC2 Asp312Asn polymorphism, significantly elevated GC risk was associated with Asn/Asn genotype (AA vs. GG + GA: OR = 1.36, 95%CI = 1.04–1.77, P = 0.02). We also found this genotype was associated with GC susceptibility among Asians and subjects without Helicobacter pylori infection. No publication bias was found in the present study.

Conclusions

This meta-analysis concluded that both ERCC2 Lys751Gln and Asp312Asn polymorphisms might contribute to increased risk of GC among Asians.

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References

  • Agalliu I, Kwon EM, Salinas CA, Koopmeiners JS, Ostrander EA, Stanford JL (2010) Genetic variation in DNA repair genes and prostate cancer risk: results from a population-based study. Cancer Causes Control 21:289–300

    Article  PubMed  Google Scholar 

  • Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50:1088–1101

    Article  PubMed  CAS  Google Scholar 

  • Canbay E, Agachan B, Gulluoglu M et al (2010) Possible associations of APE1 polymorphism with susceptibility and HOGG1 polymorphism with prognosis in gastric cancer. Anticancer Res 30:1359–1364

    PubMed  CAS  Google Scholar 

  • Capella G, Pera G, Sala N et al (2008) DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study. Int J Epidemiol 37:1316–1325

    Article  PubMed  Google Scholar 

  • Chen XZ, Jiang K, Hu JK et al (2008) Cost-effectiveness analysis of chemotherapy for advanced gastric cancer in China. World J Gastroenterol 14:2715–2722

    Article  PubMed  Google Scholar 

  • de Boer J, Hoeijmakers JH (2000) Nucleotide excision repair and human syndromes. Carcinogenesis 21:453–460

    Article  PubMed  Google Scholar 

  • Doecke J, Zhao ZZ, Pandeya N et al (2008) Polymorphisms in MGMT and DNA repair genes and the risk of esophageal adenocarcinoma. Int J Cancer 123:174–180

    Article  PubMed  CAS  Google Scholar 

  • Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634

    PubMed  CAS  Google Scholar 

  • Friedberg EC (2001) How nucleotide excision repair protects against cancer. Nat Rev Cancer 1:22–33

    Article  PubMed  CAS  Google Scholar 

  • Gonzalez CA, Sala N, Capella G (2002) Genetic susceptibility and gastric cancer risk. Int J Cancer 100:249–260

    Article  PubMed  CAS  Google Scholar 

  • Hirschhorn JN, Lohmueller K, Byrne E, Hirschhorn K (2002) A comprehensive review of genetic association studies. Genet Med 4:45–61

    Article  PubMed  CAS  Google Scholar 

  • Huang WY, Chow WH, Rothman N et al (2005) Selected DNA repair polymorphisms and gastric cancer in Poland. Carcinogenesis 26:1354–1359

    Article  PubMed  CAS  Google Scholar 

  • Ioannidis JP, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG (2001) Replication validity of genetic association studies. Nat Genet 29:306–309

    Article  PubMed  CAS  Google Scholar 

  • Jiang Z, Li C, Xu Y, Cai S (2010) A meta-analysis on XRCC1 and XRCC3 polymorphisms and colorectal cancer risk. Int J Colorectal Dis 25:169–180

    Article  PubMed  Google Scholar 

  • Laine JP, Mocquet V, Bonfanti M, Braun C, Egly JM, Brousset P (2007) Common XPD (ERCC2) polymorphisms have no measurable effect on nucleotide excision repair and basal transcription. DNA Repair (Amst) 6:1264–1270

    Article  CAS  Google Scholar 

  • Li C, Jiang Z, Liu X (2010) XPD Lys(751)Gln and Asp (312)Asn polymorphisms and bladder cancer risk: a meta-analysis. Mol Biol Rep 37:301–309

    Article  PubMed  CAS  Google Scholar 

  • Liu H, Rudolf J, Johnson KA et al (2008) Structure of the DNA repair helicase XPD. Cell 133:801–812

    Article  PubMed  CAS  Google Scholar 

  • Liu L, Zhuang W, Wang C, Chen Z, Wu XT, Zhou Y (2010) Interleukin-8–251 A/T gene polymorphism and gastric cancer susceptibility: a meta-analysis of epidemiological studies. Cytokine 50:328–334

    Article  PubMed  CAS  Google Scholar 

  • Long XD, Ma Y, Huang YZ et al (2010) Genetic polymorphisms in DNA repair genes XPC, XPD, and XRCC4, and susceptibility to Helicobacter pylori infection-related gastric antrum adenocarcinoma in Guangxi population, China. Mol Carcinog 49:611–618

    PubMed  CAS  Google Scholar 

  • Lopez-Camarillo C, Lopez-Casamichana M, Weber C, Guillen N, Orozco E, Marchat LA (2009) DNA repair mechanisms in eukaryotes: special focus in Entamoeba histolytica and related protozoan parasites. Infect Genet Evol 9:1051–1056

    Article  PubMed  CAS  Google Scholar 

  • Lou Y, Song QB, He XM (2006) Association of single nucleotide polymorphism in DNA repair gene XPD with gastric cancer in Han population from northeast region of China. World Chinese J Digest 14:3143–3146

    CAS  Google Scholar 

  • Marcon F, Palli D, Zufferli A et al (2009) Evaluation of radiation-induced chromosome instability in subjects with a family history of gastric cancer. Biomarkers 14:226–234

    Article  PubMed  CAS  Google Scholar 

  • Misra RR, Ratnasinghe D, Tangrea JA et al (2003) Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer among male smokers in Finland. Cancer Lett 191:171–178

    Article  PubMed  CAS  Google Scholar 

  • Munafo M (2004) Replication validity of genetic association studies of smoking behavior: what can meta-analytic techniques offer? Nicotine Tob Res 6:381–382

    Article  PubMed  Google Scholar 

  • Ng TT, McGory ML, Ko CY, Maggard MA (2006) Meta-analysis in surgery: methods and limitations. Arch Surg 141:1125–1130

    Article  PubMed  Google Scholar 

  • Norppa H (2003) Genetic susceptibility, biomarker response, and cancer. Mutat Res 544:339–348

    Article  PubMed  CAS  Google Scholar 

  • Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55:74–108

    Article  PubMed  Google Scholar 

  • Qiu LX, Yao L, Zhang J et al (2010) XPD Lys751Gln polymorphism and breast cancer susceptibility: a meta-analysis involving 28,709 subjects. Breast Cancer Res Treat 124:229–235

    Google Scholar 

  • Ruzzo A, Canestrari E, Maltese P et al (2007) Polymorphisms in genes involved in DNA repair and metabolism of xenobiotics in individual susceptibility to sporadic diffuse gastric cancer. Clin Chem Lab Med 45:822–828

    Article  PubMed  CAS  Google Scholar 

  • Veglia F, Loft S, Matullo G et al (2008) DNA adducts and cancer risk in prospective studies: a pooled analysis and a meta-analysis. Carcinogenesis 29:932–936

    Article  PubMed  CAS  Google Scholar 

  • Wang F, Chang D, Hu FL et al (2008) DNA repair gene XPD polymorphisms and cancer risk: a meta-analysis based on 56 case-control studies. Cancer Epidemiol Biomarkers Prev 17:507–517

    Article  PubMed  CAS  Google Scholar 

  • Wang H, Zhou Y, Zhuang W et al (2010) Glutathione S-transferase M1 null genotype associated with gastric cancer among Asians. Dig Dis Sci 55:1824–1830

    Article  PubMed  CAS  Google Scholar 

  • Winkler GS, Araujo SJ, Fiedler U et al (2000) TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair. J Biol Chem 275:4258–4266

    Article  PubMed  CAS  Google Scholar 

  • Yang L (2006) Incidence and mortality of gastric cancer in China. World J Gastroenterol 12:17–20

    PubMed  Google Scholar 

  • Ye W, Kumar R, Bacova G, Lagergren J, Hemminki K, Nyren O (2006) The XPD 751Gln allele is associated with an increased risk for esophageal adenocarcinoma: a population-based case-control study in Sweden. Carcinogenesis 27:1835–1841

    Article  PubMed  CAS  Google Scholar 

  • Zhang CZ, Chen ZP, Xu CQ, Ning T, Li DP, Hou RP (2009) Correlation of XPD gene with susceptibility to gastric cancer. Ai Zheng 28:1163–1167

    PubMed  CAS  Google Scholar 

  • Zhang J, Gu SY, Zhang P, Jia Z, Chang JH (2010) ERCC2 Lys751Gln polymorphism is associated with lung cancer among Caucasians. Eur J Cancer 46:2479–2484

    Article  PubMed  CAS  Google Scholar 

  • Zhou RM, Li Y, Wang N, Dong XJ, Zhang XJ, Guo W (2007) Correlation between single nucleotide polymorphism of DNA repair gene XPD and the risks of esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma. Tumor 27:118–133

    CAS  Google Scholar 

  • Zhou Y, Li N, Zhuang W et al (2009) Glutathione S-transferase P1 gene polymorphism associated with gastric cancer among Caucasians. Eur J Cancer 45:1438–1442

    Article  PubMed  CAS  Google Scholar 

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Conflict of interest

We declare that we have no conflict of interest. There is no source of funding for each author, for the study, and for the manuscript preparation.

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Authors and Affiliations

  1. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, 37 Guo Xue Road, Chengdu, 610041, Sichuan Province, China

    Bo Chen, Yong Zhou, Ping Yang & Xiao-Ting Wu

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  1. Bo Chen
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  2. Yong Zhou
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  3. Ping Yang
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  4. Xiao-Ting Wu
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Correspondence to Xiao-Ting Wu.

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Chen, B., Zhou, Y., Yang, P. et al. ERCC2 Lys751Gln and Asp312Asn polymorphisms and gastric cancer risk: a meta-analysis. J Cancer Res Clin Oncol 137, 939–946 (2011). https://doi.org/10.1007/s00432-010-0956-y

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  • DOI: https://doi.org/10.1007/s00432-010-0956-y

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