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Human NAD(P)H:quinone oxidoreductase 1 (NQO1) and sulfotransferase 1A1 (SULT1A1) polymorphisms and urothelial cancer risk in Taiwan

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Abstract

Purpose

To investigate whether the NAD(P)H:quinone oxidoreductase 1 (NQO1) and sulfotransferase 1A1 (SULT1A1) polymorphisms are associated with urothelial cancer (UC) risk in Taiwan.

Methods

In this study, 600 study subjects (including 300 UC patients and 300 cancer-free controls) were recruited from September 1998 to December 2005. We analyzed the NQO1 and SULT1A1 polymorphisms by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. A comprehensive interview was conducted to collect information, including baseline characteristics and cigarette smoking status. We used an unconditional multivariate logistic regression to calculate the odds ratio (OR) and 95% confidence interval (CI).

Results

We found a significantly increased UC risk in study subjects with the NQO1 C/T and T/T genotypes (OR = 1.5; 95% CI: 1.03–2.1). A significantly increased UC risk was found in those with the SULT1A1 G/G genotype (OR = 2.0; 95% CI: 1.3–3.2). Subjects who had ever smoked with either the NQO1 C/T and T/T genotypes or the SULT1A1 G/G genotype had significantly increased UC risks, showing ORs of 3.0 and 5.3, respectively. Subjects carrying both the NQO1 C/T and T/T genotypes and the SULT1A1 G/G genotype had a significantly increased UC risk (OR = 3.7; 95% CI, 1.4–9.7). Moreover, those who had ever smoked with both the NQO1 C/T and T/T genotypes and the SULT1A1 G/G genotype had the highest UC risk (OR = 8.6; 95% CI: 2.5–29.7).

Conclusions

These findings suggest that NQO1 and SULT1A1 polymorphisms are associated with the risk of UC, particularly among those who have ever smoked.

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Acknowledgments

This study was supported by grants from the National Science Council of Taiwan (NSC 95-2314-B-038-047-MY3); Topnotch Stroke Research Center Grant, Ministry of Education; Center of Excellence for Clinical Trial and Research in Stroke and TBI (DOH-TD-B-111-002).

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Authors and Affiliations

  1. School of Public Health, Topnotch Stroke Research Center, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 110, Taiwan

    Yuan-Hung Wang & Hung-Yi Chiou

  2. Department of Urology, Chi Mei Medical Center, Tainan, Taiwan

    Ying-Huei Lee & Po-Tsang Tseng

  3. Department of Urology, Chia Yi Christian Hospital, Chiayi, Taiwan

    Cheng-Huang Shen

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  1. Yuan-Hung Wang
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  2. Ying-Huei Lee
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Correspondence to Hung-Yi Chiou.

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Wang, YH., Lee, YH., Tseng, PT. et al. Human NAD(P)H:quinone oxidoreductase 1 (NQO1) and sulfotransferase 1A1 (SULT1A1) polymorphisms and urothelial cancer risk in Taiwan. J Cancer Res Clin Oncol 134, 203–209 (2008). https://doi.org/10.1007/s00432-007-0271-4

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  • DOI: https://doi.org/10.1007/s00432-007-0271-4

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