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A case–control study investigating the role of sulfotransferase 1A1 polymorphism in head and neck cancer

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Abstract

Purpose: Sulfotransferases (SULT) 1A1 detoxifie and bioactivate a broad spectrum of substrates including xenobiotics. The SULT1A1 gene possesses a G→A polymorphism that results in an Arg to His substitution at codon 213, with the His allele having a low activity. The purpose of this study was to evaluate whether SULT1A1 Arg213His polymorphisms are risk factors for head and neck squamous cell carcinoma (SCCHN). Methods: A total of 124 consecutive primary SCCHN patients and 249 age- and sex-matched hospital controls were enrolled in this study. Genomic DNA was isolated from peripheral blood lymphocytes and genotyping was performed by PCR-RFLP. A comprehensive epidemiological interview was conducted on all participants to collect their lifestyle data. Results: The His/His frequencies in cases and controls were 6.5% (8/123) and 3.6% (9/247), respectively (P=0.049). Multivariate logistic regression analysis showed a significant association of SCCHN and His/His genotype (OR=3.60; 95% CI=1.01–12.88). This association was stronger amongst older people, alcohol and low fruit consumers. The resulted SULT1A1 His/His genotype also associated with a higher risk of neck node positive status (OR=5.82; 95% CI=1.10–30.68). Conclusions: These preliminary findings show for the first time that the SULT1A1 His 213 allele is a possible risk factor for head and neck cancer development.

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Authors and Affiliations

  1. Institute of Hygiene, Catholic University of the Sacred Heart, L.go F. Vito 1, 00168, Rome, Italy

    Stefania Boccia, Giuseppe La Torre, Dario Arzani, Francesco Gianfagna & Gualtiero Ricciardi

  2. Department of Otorhinolaryngology, Catholic University of the Sacred Heart, Rome, Italy

    Gabriella Cadoni, Mariangela Volante, Gaetano Paludetti & Giovanni Almadori

  3. Geriatric Medicine, Catholic University of the Sacred Heart, Rome, Italy

    Caterina Cattel

Authors
  1. Stefania Boccia
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  2. Gabriella Cadoni
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  3. Giuseppe La Torre
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  4. Dario Arzani
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  5. Mariangela Volante
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  6. Caterina Cattel
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  7. Francesco Gianfagna
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  8. Gaetano Paludetti
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  9. Giovanni Almadori
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  10. Gualtiero Ricciardi
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Correspondence to Stefania Boccia.

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Boccia, S., Cadoni, G., La Torre, G. et al. A case–control study investigating the role of sulfotransferase 1A1 polymorphism in head and neck cancer. J Cancer Res Clin Oncol 132, 466–472 (2006). https://doi.org/10.1007/s00432-006-0093-9

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  • DOI: https://doi.org/10.1007/s00432-006-0093-9

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